Atomistry » Zinc » PDB 7ay1-7bbd » 7b4d
Atomistry »
  Zinc »
    PDB 7ay1-7bbd »
      7b4d »

Zinc in PDB 7b4d: Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R273C/S240R Double Mutant Bound to Dna and Mq: R273C/S240R-Dna-Mq

Protein crystallography data

The structure of Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R273C/S240R Double Mutant Bound to Dna and Mq: R273C/S240R-Dna-Mq, PDB code: 7b4d was solved by H.Rozenberg, Y.Diskin-Posner, O.Degtjarik, Z.Shakked, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.28 / 1.85
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 137.587, 50.164, 34.231, 90, 92.6, 90
R / Rfree (%) 16.8 / 20.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R273C/S240R Double Mutant Bound to Dna and Mq: R273C/S240R-Dna-Mq (pdb code 7b4d). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R273C/S240R Double Mutant Bound to Dna and Mq: R273C/S240R-Dna-Mq, PDB code: 7b4d:

Zinc binding site 1 out of 1 in 7b4d

Go back to Zinc Binding Sites List in 7b4d
Zinc binding site 1 out of 1 in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R273C/S240R Double Mutant Bound to Dna and Mq: R273C/S240R-Dna-Mq


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R273C/S240R Double Mutant Bound to Dna and Mq: R273C/S240R-Dna-Mq within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:30.6
occ:1.00
ND1 A:HIS179 2.0 26.7 1.0
SG A:CYS176 2.3 29.9 1.0
SG A:CYS238 2.3 34.8 1.0
SG A:CYS242 2.3 28.8 1.0
CE1 A:HIS179 2.9 34.3 1.0
CG A:HIS179 3.1 27.3 1.0
CB A:CYS242 3.2 25.1 1.0
CB A:CYS238 3.2 27.8 1.0
CB A:CYS176 3.3 38.1 1.0
CB A:HIS179 3.5 33.6 1.0
CA A:CYS238 3.8 18.1 1.0
NE2 A:HIS179 4.1 31.8 1.0
N A:CYS176 4.1 31.9 1.0
CD2 A:HIS179 4.2 28.2 1.0
CA A:CYS176 4.2 36.4 1.0
N A:HIS179 4.3 37.0 1.0
O A:MET237 4.4 31.8 1.0
N A:ASN239 4.4 29.7 1.0
CA A:HIS179 4.6 39.4 1.0
CA A:CYS242 4.6 29.4 1.0
C A:CYS238 4.7 27.8 1.0
O A:CYS176 4.8 27.4 1.0
C A:CYS176 4.8 27.1 1.0
N A:CYS238 4.9 25.1 1.0
O A:HOH473 5.0 33.0 1.0

Reference:

O.Degtjarik, D.Golovenko, Y.Diskin-Posner, L.Abrahmsen, H.Rozenberg, Z.Shakked. P53 Structure 7 To Be Published.
Page generated: Fri Dec 17 11:45:57 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy