Zinc in PDB 7ay1: Cryo-Em Structure of USP1-UAF1 Bound to Mono-Ubiquitinated FANCD2, and Fanci

All present enzymatic activity of Cryo-Em Structure of USP1-UAF1 Bound to Mono-Ubiquitinated FANCD2, and Fanci:
3.4.19.12;

The binding sites of Zinc atom in the Cryo-Em Structure of USP1-UAF1 Bound to Mono-Ubiquitinated FANCD2, and Fanci (pdb code 7ay1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of USP1-UAF1 Bound to Mono-Ubiquitinated FANCD2, and Fanci, PDB code: 7ay1:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of USP1-UAF1 Bound to Mono-Ubiquitinated FANCD2, and Fanci


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of USP1-UAF1 Bound to Mono-Ubiquitinated FANCD2, and Fanci within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1000 b:71.6 occ:1.00 SG D:CYS443 2.2 37.0 1.0 SG D:CYS440 2.2 32.0 1.0 SG D:CYS509 2.3 28.1 1.0 SG D:CYS506 2.3 29.7 1.0 CB D:CYS443 2.8 37.0 1.0 CB D:CYS440 3.0 32.0 1.0 CB D:CYS506 3.3 29.7 1.0 CB D:CYS509 3.6 28.1 1.0 N D:CYS443 3.7 37.0 1.0 CA D:CYS443 3.8 37.0 1.0 N D:CYS509 4.0 28.1 1.0 CB D:ASN508 4.4 33.3 1.0 CA D:CYS509 4.4 28.1 1.0 CA D:CYS440 4.5 32.0 1.0 C D:ASN508 4.7 33.3 1.0 O D:CYS440 4.7 32.0 1.0 C D:CYS443 4.7 37.0 1.0 CA D:CYS506 4.8 29.7 1.0 C D:CYS440 4.8 32.0 1.0 C D:GLU442 4.8 34.6 1.0 N D:ASN508 4.8 33.3 1.0 CA D:ASN508 4.9 33.3 1.0 CG2 D:THR513 4.9 28.9 1.0 N D:GLU444 5.0 34.0 1.0

M.L.Rennie, C.Arkinson, V.K.Chaugule, R.Toth, H.Walden. Structural Basis of FANCD2 Deubiquitination By USP1-UAF1 Biorxiv 2020.
DOI: 10.1101/2020.12.05.412924