Zinc in PDB 7ay0: Crystal Structure of Truncated USP1-UAF1

All present enzymatic activity of Crystal Structure of Truncated USP1-UAF1:
3.4.19.12;

The structure of Crystal Structure of Truncated USP1-UAF1, PDB code: 7ay0 was solved by C.Arkinson, M.L.Rennie, H.Walden, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.78 / 3.60
Space group	P 41
Cell size a, b, c (Å), α, β, γ (°)	119.57, 119.57, 195.46, 90, 90, 90
R / Rfree (%)	23.5 / 26.6

The binding sites of Zinc atom in the Crystal Structure of Truncated USP1-UAF1 (pdb code 7ay0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Truncated USP1-UAF1, PDB code: 7ay0:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Truncated USP1-UAF1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Truncated USP1-UAF1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1000 b:68.8 occ:1.00 SG B:CYS506 2.3 46.1 1.0 SG B:CYS509 2.3 47.8 1.0 SG B:CYS443 2.3 49.9 1.0 SG B:CYS440 2.3 49.2 1.0 CB B:CYS506 3.0 42.2 1.0 CB B:CYS440 3.2 41.7 1.0 CB B:CYS509 3.3 43.6 1.0 CB B:CYS443 3.4 46.7 1.0 N B:CYS509 3.7 49.4 1.0 N B:CYS443 3.9 46.6 1.0 CA B:CYS509 4.1 46.3 1.0 CA B:CYS443 4.3 48.6 1.0 CG2 B:THR513 4.4 38.6 1.0 CA B:CYS506 4.5 47.6 1.0 CB B:ASN508 4.5 45.3 1.0 OG1 B:THR513 4.5 47.9 1.0 CA B:CYS440 4.7 42.6 1.0 CB B:GLU442 4.7 51.7 1.0 C B:ASN508 4.7 50.2 1.0 C B:GLU442 4.8 52.6 1.0 CB B:THR513 4.9 37.3 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Truncated USP1-UAF1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Truncated USP1-UAF1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1000 b:69.7 occ:1.00 SG D:CYS506 2.3 46.5 1.0 SG D:CYS509 2.3 68.8 1.0 SG D:CYS443 2.3 61.9 1.0 SG D:CYS440 2.3 56.2 1.0 CB D:CYS506 3.2 45.0 1.0 CB D:CYS440 3.2 32.4 1.0 CB D:CYS509 3.4 59.1 1.0 CB D:CYS443 3.4 56.3 1.0 N D:CYS509 3.8 62.4 1.0 N D:CYS443 3.8 50.5 1.0 CA D:CYS509 4.1 57.7 1.0 CA D:CYS443 4.2 55.5 1.0 CB D:ASN508 4.4 54.6 1.0 CG2 D:THR513 4.4 38.4 1.0 OG1 D:THR513 4.6 47.5 1.0 CA D:CYS440 4.6 34.6 1.0 CA D:CYS506 4.6 53.0 1.0 CB D:GLU442 4.6 52.6 1.0 C D:ASN508 4.7 59.1 1.0 C D:GLU442 4.7 51.6 1.0 O D:CYS440 4.9 46.9 1.0 C D:CYS440 5.0 42.6 1.0 CB D:THR513 5.0 36.1 1.0 CA D:ASN508 5.0 57.4 1.0

M.L.Rennie, C.Arkinson, V.K.Chaugule, R.Toth, H.Walden. Structural Basis of FANCD2 Deubiquitination By USP1-UAF1 Biorxiv 2020.
DOI: 10.1101/2020.12.05.412924