Zinc in PDB 7at8: Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.

All present enzymatic activity of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.:
2.1.1.356;

The binding sites of Zinc atom in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. (pdb code 7at8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 7 binding sites of Zinc where determined in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2., PDB code: 7at8:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7;

Zinc binding site 1 out of 7 in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:0.3 occ:1.00 ND1 A:HIS297 2.1 0.0 1.0 SG A:CYS289 2.3 0.9 1.0 SG A:CYS286 2.3 0.7 1.0 SG A:CYS294 2.3 0.6 0.9 CB A:CYS289 2.4 0.9 1.0 CE1 A:HIS297 2.5 0.0 1.0 CB A:CYS286 3.1 0.7 1.0 CB A:CYS294 3.1 0.6 1.0 CG A:HIS297 3.4 0.0 1.0 N A:CYS289 3.4 0.9 1.0 CA A:CYS289 3.5 0.9 1.0 NE2 A:HIS297 3.8 0.0 1.0 CB A:HIS297 4.1 0.0 1.0 O A:CYS286 4.2 0.7 1.0 CD2 A:HIS297 4.2 0.0 1.0 CA A:CYS286 4.4 0.7 1.0 C A:ARG288 4.4 0.6 1.0 C A:CYS289 4.5 0.9 1.0 CA A:CYS294 4.5 0.6 1.0 C A:CYS286 4.6 0.7 1.0 N A:HIS297 4.7 0.0 1.0 N A:CYS294 4.7 0.6 1.0 N A:PHE290 4.8 0.2 1.0 CB A:LEU296 4.9 0.2 1.0 CB A:ARG288 4.9 0.6 1.0

Zinc binding site 2 out of 7 in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:1.0 occ:1.00 SG A:CYS548 2.3 0.5 1.0 SG A:CYS567 2.3 0.5 1.0 SG A:CYS571 2.3 0.8 1.0 SG A:CYS561 2.3 0.8 1.0 CB A:CYS567 2.9 0.5 1.0 CB A:CYS561 3.2 0.8 1.0 CB A:CYS571 3.3 0.8 1.0 CB A:CYS548 3.4 0.5 1.0 ZN A:ZN1003 3.9 0.2 1.0 ZN A:ZN1004 3.9 0.4 1.0 SG A:CYS541 4.2 1.0 1.0 CB A:ASN573 4.3 0.5 1.0 CA A:CYS567 4.4 0.5 1.0 CG A:ARG574 4.4 0.9 1.0 ND2 A:ASN573 4.6 0.5 1.0 NE A:ARG574 4.7 0.9 1.0 CA A:CYS561 4.7 0.8 1.0 CA A:CYS548 4.7 0.5 1.0 CA A:CYS571 4.8 0.8 1.0 CB A:CYS565 4.8 0.3 1.0 N A:ARG574 4.8 0.9 1.0

Zinc binding site 3 out of 7 in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1003 b:0.2 occ:1.00 NE2 A:HIS543 2.1 0.9 1.0 SG A:CYS548 2.3 0.5 1.0 SG A:CYS541 2.3 1.0 1.0 SG A:CYS552 2.3 0.7 1.0 CD2 A:HIS543 2.6 0.9 1.0 CB A:CYS541 3.1 1.0 1.0 CE1 A:HIS543 3.3 0.9 1.0 CB A:CYS548 3.4 0.5 1.0 CB A:CYS552 3.6 0.7 1.0 ZN A:ZN1004 3.8 0.4 1.0 ZN A:ZN1002 3.9 1.0 1.0 CG A:HIS543 3.9 0.9 1.0 CA A:CYS548 4.0 0.5 1.0 SG A:CYS561 4.2 0.8 1.0 ND1 A:HIS543 4.2 0.9 1.0 CB A:CYS567 4.3 0.5 1.0 CA A:CYS541 4.4 1.0 1.0 C A:CYS541 4.6 1.0 1.0 CA A:CYS552 4.6 0.7 1.0 CD A:PRO553 4.7 0.1 1.0 SG A:CYS554 4.7 0.3 0.9 N A:CYS548 4.7 0.5 1.0 N A:ASP542 4.8 0.1 1.0 O A:CYS541 4.9 1.0 1.0 CB A:CYS554 5.0 0.3 1.0

Zinc binding site 4 out of 7 in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1004 b:0.4 occ:1.00 SG A:CYS541 2.3 1.0 1.0 SG A:CYS554 2.3 0.3 0.9 SG A:CYS561 2.3 0.8 1.0 SG A:CYS565 2.3 0.3 1.0 CB A:CYS561 3.2 0.8 1.0 CB A:CYS565 3.3 0.3 1.0 CB A:CYS541 3.3 1.0 1.0 CA A:CYS561 3.5 0.8 1.0 CB A:CYS554 3.6 0.3 1.0 ZN A:ZN1003 3.8 0.2 1.0 ZN A:ZN1002 3.9 1.0 1.0 N A:CYS541 4.1 1.0 1.0 CA A:CYS541 4.3 1.0 1.0 N A:CYS561 4.4 0.8 1.0 SG A:CYS552 4.4 0.7 1.0 SG A:CYS567 4.5 0.5 1.0 CA A:CYS565 4.5 0.3 1.0 SG A:CYS548 4.6 0.5 1.0 ND2 A:ASN573 4.6 0.5 1.0 C A:CYS561 4.6 0.8 1.0 CE1 A:TYR538 4.7 0.2 1.0 N A:GLU562 4.7 0.4 1.0 OH A:TYR538 4.8 0.2 1.0 O A:PHE560 4.9 0.8 1.0 CA A:CYS554 4.9 0.3 1.0 O A:CYS541 5.0 1.0 1.0 C A:PHE560 5.0 0.8 1.0 C A:PRO540 5.0 0.9 1.0

Zinc binding site 5 out of 7 in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1005 b:0.3 occ:1.00 SG A:CYS619 2.3 0.7 1.0 SG A:CYS606 2.3 0.5 1.0 SG A:CYS598 2.3 0.8 1.0 SG A:CYS584 2.3 0.9 1.0 CB A:CYS606 3.1 0.5 1.0 CB A:CYS598 3.3 0.8 1.0 CB A:CYS619 3.6 0.7 1.0 ZN A:ZN1007 3.7 0.7 1.0 ZN A:ZN1006 3.7 0.3 1.0 SG A:CYS578 3.8 0.4 1.0 O A:GLN583 4.0 0.3 1.0 CB A:CYS584 4.1 0.9 1.0 CB A:ASN621 4.2 0.9 1.0 CA A:CYS606 4.5 0.5 1.0 CA A:CYS619 4.6 0.7 1.0 O A:CYS584 4.7 0.9 1.0 CB A:CYS603 4.7 0.9 1.0 CA A:CYS598 4.8 0.8 1.0 C A:GLN583 4.8 0.3 1.0 ND2 A:ASN621 4.8 0.9 1.0 O A:ALA582 4.8 0.6 1.0 C A:CYS606 5.0 0.5 1.0 SG A:CYS603 5.0 0.9 1.0

Zinc binding site 6 out of 7 in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1006 b:0.3 occ:1.00 SG A:CYS603 2.3 0.9 1.0 SG A:CYS598 2.3 0.8 1.0 SG A:CYS578 2.3 0.4 1.0 SG A:CYS591 2.3 0.7 1.0 CB A:CYS591 3.0 0.7 1.0 CB A:CYS598 3.2 0.8 1.0 CB A:CYS578 3.2 0.4 1.0 CB A:CYS603 3.4 0.9 1.0 N A:CYS578 3.4 0.4 1.0 CA A:CYS598 3.7 0.8 1.0 ZN A:ZN1005 3.7 0.3 1.0 ZN A:ZN1007 3.9 0.7 1.0 CA A:CYS578 3.9 0.4 1.0 SG A:CYS606 4.3 0.5 1.0 C A:GLY577 4.4 0.1 1.0 CA A:CYS591 4.4 0.7 1.0 SG A:CYS589 4.5 0.5 1.0 N A:CYS598 4.6 0.8 1.0 CA A:GLY577 4.6 0.1 1.0 O A:CYS578 4.6 0.4 1.0 CA A:CYS603 4.6 0.9 1.0 SG A:CYS584 4.7 0.9 1.0 C A:CYS578 4.7 0.4 1.0 C A:CYS598 4.8 0.8 1.0 N A:ASP599 4.8 0.1 1.0 N A:CYS591 4.8 0.7 1.0 ND2 A:ASN621 5.0 0.9 1.0

Zinc binding site 7 out of 7 in the Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Histone H3 Recognition By Nucleosome-Bound PRC2 Subunit EZH2. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1007 b:0.7 occ:1.00 SG A:CYS578 2.3 0.4 1.0 SG A:CYS589 2.3 0.5 1.0 SG A:CYS580 2.3 0.1 1.0 SG A:CYS584 2.3 0.9 1.0 CB A:CYS584 2.4 0.9 1.0 CB A:CYS578 3.0 0.4 1.0 CB A:CYS580 3.4 0.1 1.0 CB A:CYS589 3.4 0.5 1.0 ZN A:ZN1005 3.7 0.3 1.0 CA A:CYS584 3.9 0.9 1.0 ZN A:ZN1006 3.9 0.3 1.0 O A:CYS584 4.0 0.9 1.0 SG A:CYS598 4.2 0.8 1.0 C A:CYS584 4.4 0.9 1.0 CA A:CYS589 4.4 0.5 1.0 CA A:CYS578 4.5 0.4 1.0 N A:CYS580 4.6 0.1 1.0 CB A:CYS591 4.6 0.7 1.0 CA A:CYS580 4.6 0.1 1.0 CB A:CYS606 4.7 0.5 1.0 SG A:CYS606 4.7 0.5 1.0 C A:CYS578 4.8 0.4 1.0 N A:CYS584 4.8 0.9 1.0 SG A:CYS591 5.0 0.7 1.0

K.Finogenova, J.Bonnet, S.Poepsel, I.B.Schafer, K.Finkl, K.Schmid, C.Litz, M.Strauss, C.Benda, J.Muller. Structural Basis For PRC2 Decoding of Active Histone Methylation Marks H3K36ME2/3. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33211010
DOI: 10.7554/ELIFE.61964