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Zinc in PDB 7aov: Crystal Structure of A TRPM2 Domain

Protein crystallography data

The structure of Crystal Structure of A TRPM2 Domain, PDB code: 7aov was solved by S.Sander, H.Tidow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.61 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.76, 188.128, 47.773, 90, 102.66, 90
R / Rfree (%) 18.8 / 23.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of A TRPM2 Domain (pdb code 7aov). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of A TRPM2 Domain, PDB code: 7aov:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7aov

Go back to Zinc Binding Sites List in 7aov
Zinc binding site 1 out of 2 in the Crystal Structure of A TRPM2 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A TRPM2 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:30.6
occ:1.00
NE2 A:HIS74 2.1 28.0 1.0
SG A:CYS65 2.3 29.8 1.0
SG A:CYS53 2.3 31.4 1.0
SG A:CYS67 2.3 28.4 1.0
CB A:CYS65 3.0 28.9 1.0
CD2 A:HIS74 3.1 27.3 1.0
CB A:CYS53 3.1 26.4 1.0
CE1 A:HIS74 3.1 34.7 1.0
CB A:CYS67 3.3 22.8 1.0
O A:PHE55 4.0 29.1 1.0
N A:CYS67 4.0 34.1 1.0
CA A:CYS67 4.2 28.0 1.0
CG A:HIS74 4.2 36.6 1.0
ND1 A:HIS74 4.2 27.8 1.0
NE1 A:TRP89 4.3 31.1 1.0
CA A:TYR56 4.3 31.0 1.0
O A:HOH763 4.4 34.4 1.0
CA A:CYS65 4.5 38.1 1.0
CA A:CYS53 4.6 30.7 1.0
C A:PHE55 4.6 35.8 1.0
CD1 A:TYR56 4.7 29.2 1.0
N A:TYR56 4.8 31.7 1.0
CE2 A:TRP89 4.9 35.6 1.0
C A:CYS65 4.9 38.3 1.0
CZ2 A:TRP89 4.9 40.6 1.0
N A:LYS66 4.9 36.1 1.0

Zinc binding site 2 out of 2 in 7aov

Go back to Zinc Binding Sites List in 7aov
Zinc binding site 2 out of 2 in the Crystal Structure of A TRPM2 Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A TRPM2 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn501

b:31.0
occ:1.00
NE2 B:HIS74 2.2 32.5 1.0
SG B:CYS53 2.3 30.1 1.0
SG B:CYS65 2.3 28.6 1.0
SG B:CYS67 2.3 29.3 1.0
CB B:CYS65 3.0 29.3 1.0
CD2 B:HIS74 3.1 31.3 1.0
CB B:CYS53 3.1 24.5 1.0
CE1 B:HIS74 3.2 35.7 1.0
CB B:CYS67 3.2 24.2 1.0
O B:PHE55 4.0 33.5 1.0
N B:CYS67 4.1 30.5 1.0
CA B:CYS67 4.2 31.1 1.0
CG B:HIS74 4.3 34.0 1.0
ND1 B:HIS74 4.3 30.7 1.0
CA B:TYR56 4.4 29.6 1.0
NE1 B:TRP89 4.4 33.7 1.0
O B:HOH772 4.5 36.4 1.0
CA B:CYS65 4.5 36.9 1.0
CA B:CYS53 4.6 31.7 1.0
C B:PHE55 4.6 37.6 1.0
CD1 B:TYR56 4.7 29.5 1.0
N B:TYR56 4.8 32.7 1.0
C B:CYS65 4.9 36.9 1.0
CE2 B:TRP89 4.9 31.9 1.0
N B:LYS66 4.9 33.6 1.0
CZ2 B:TRP89 5.0 43.4 1.0

Reference:

S.Sander, J.Pick, E.Gattkowski, R.Fliegert, H.Tidow. The Crystal Structure of TRPM2 MHR1/2 Domain Reveals A Conserved Zn 2+ -Binding Domain Essential For Structural Integrity and Channel Activity. Protein Sci. V. 31 E4320 2022.
ISSN: ESSN 1469-896X
PubMed: 35634784
DOI: 10.1002/PRO.4320
Page generated: Tue Oct 29 17:00:51 2024

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