Zinc in PDB 6y5d: Structure of Human Cgas (K394E) Bound to the Nucleosome

All present enzymatic activity of Structure of Human Cgas (K394E) Bound to the Nucleosome:
2.7.7.86;

The binding sites of Zinc atom in the Structure of Human Cgas (K394E) Bound to the Nucleosome (pdb code 6y5d). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Human Cgas (K394E) Bound to the Nucleosome, PDB code: 6y5d:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Human Cgas (K394E) Bound to the Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human Cgas (K394E) Bound to the Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn601 b:0.7 occ:1.01 NE2 K:HIS390 2.0 0.7 0.0 SG K:CYS397 2.3 0.6 0.0 SG K:CYS404 2.3 0.1 0.0 SG K:CYS396 2.3 0.6 0.0 CD2 K:HIS390 3.0 0.2 0.0 CE1 K:HIS390 3.0 0.8 0.0 CB K:CYS404 3.4 0.7 0.0 CB K:CYS397 3.5 0.5 0.0 CB K:CYS396 3.6 0.8 0.0 C K:CYS396 3.7 0.1 1.0 O K:CYS396 3.7 0.0 1.0 N K:CYS404 3.8 0.6 1.0 N K:CYS397 3.9 0.1 1.0 ND1 K:HIS390 4.0 0.9 0.0 CA K:CYS404 4.0 0.6 1.0 CG K:HIS390 4.0 0.2 0.0 O K:CYS404 4.2 0.1 1.0 O K:GLU402 4.3 0.8 1.0 CA K:CYS396 4.3 0.3 1.0 CA K:CYS397 4.3 0.7 1.0 C K:CYS404 4.4 0.0 1.0 NH1 K:ARG406 4.9 0.9 0.0 C K:LYS403 4.9 0.0 1.0

Zinc binding site 2 out of 2 in the Structure of Human Cgas (K394E) Bound to the Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Human Cgas (K394E) Bound to the Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn601 b:0.0 occ:1.01 NE2 L:HIS390 2.0 0.0 0.0 SG L:CYS397 2.3 0.0 0.0 SG L:CYS404 2.3 0.0 0.0 SG L:CYS396 2.3 0.0 0.0 CD2 L:HIS390 2.9 0.0 0.0 CE1 L:HIS390 2.9 0.0 0.0 CB L:CYS404 3.3 0.0 0.0 CB L:CYS397 3.5 0.0 0.0 CB L:CYS396 3.6 0.0 0.0 C L:CYS396 3.7 0.0 1.0 N L:CYS404 3.7 0.0 1.0 O L:CYS396 3.7 0.0 1.0 N L:CYS397 3.9 0.0 1.0 CG L:HIS390 3.9 0.0 0.0 ND1 L:HIS390 3.9 0.0 0.0 CA L:CYS404 4.0 0.0 1.0 O L:GLU402 4.2 0.0 1.0 CA L:CYS396 4.3 0.0 1.0 O L:CYS404 4.3 0.0 1.0 CA L:CYS397 4.3 0.0 1.0 C L:CYS404 4.4 0.0 1.0 C L:LYS403 4.8 0.0 1.0 NH1 L:ARG406 5.0 0.0 0.0

G.R.Pathare, A.Decout, S.Gluck, S.Cavadini, K.Makasheva, R.Hovius, G.Kempf, J.Weiss, Z.Kozicka, B.Guey, P.Melenec, B.Fierz, N.H.Thoma, A.Ablasser. Structural Mechanism of Cgas Inhibition By the Nucleosome. Nature V. 587 668 2020.
ISSN: ESSN 1476-4687
PubMed: 32911482
DOI: 10.1038/S41586-020-2750-6