Atomistry » Zinc » PDB 6x46-6xgu » 6x9j
Atomistry »
  Zinc »
    PDB 6x46-6xgu »
      6x9j »

Zinc in PDB 6x9j: Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052

Enzymatic activity of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052

All present enzymatic activity of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052:
2.1.1.37;

Protein crystallography data

The structure of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052, PDB code: 6x9j was solved by S.Pathuri, J.R.Horton, X.Cheng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.92 / 1.79
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 160.058, 77.765, 116.72, 90, 125.35, 90
R / Rfree (%) 20 / 22.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052 (pdb code 6x9j). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052, PDB code: 6x9j:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6x9j

Go back to Zinc Binding Sites List in 6x9j
Zinc binding site 1 out of 2 in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1701

b:69.5
occ:1.00
NE2 A:HIS1502 2.1 111.3 1.0
SG A:CYS1478 2.2 93.7 1.0
SG A:CYS1476 2.2 79.2 1.0
SG A:CYS1485 2.4 93.8 1.0
CE1 A:HIS1502 3.0 106.6 1.0
CB A:CYS1478 3.1 92.8 1.0
CD2 A:HIS1502 3.2 107.2 1.0
CB A:CYS1485 3.3 96.4 1.0
CB A:CYS1476 3.7 78.2 1.0
CA A:CYS1485 3.7 98.4 1.0
CA A:CYS1478 4.0 92.3 1.0
N A:CYS1478 4.0 90.9 1.0
ND1 A:HIS1502 4.1 103.7 1.0
CG A:HIS1502 4.3 101.7 1.0
N A:CYS1485 4.5 100.2 1.0
C A:CYS1485 4.9 100.3 1.0
CA A:CYS1476 5.0 82.3 1.0

Zinc binding site 2 out of 2 in 6x9j

Go back to Zinc Binding Sites List in 6x9j
Zinc binding site 2 out of 2 in the Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1702

b:40.4
occ:1.00
NE2 A:HIS793 2.1 52.7 1.0
SG A:CYS896 2.2 50.4 1.0
SG A:CYS893 2.2 47.3 1.0
SG A:CYS820 2.3 45.5 1.0
CB A:CYS820 3.0 43.2 1.0
CD2 A:HIS793 3.0 49.6 1.0
CE1 A:HIS793 3.1 51.2 1.0
CB A:CYS893 3.3 50.1 1.0
CB A:CYS896 3.3 49.9 1.0
N A:CYS896 3.4 48.7 1.0
CA A:CYS896 3.8 48.9 1.0
ND1 A:HIS793 4.2 50.6 1.0
CG A:HIS793 4.2 48.2 1.0
O A:HOH2110 4.2 61.3 1.0
CB A:SER895 4.2 46.2 1.0
C A:SER895 4.3 45.1 1.0
CA A:CYS820 4.4 40.6 1.0
OG A:SER895 4.5 44.6 1.0
CA A:CYS893 4.6 52.7 1.0
CA A:SER895 4.7 45.1 1.0
C A:CYS820 4.7 40.4 1.0
O A:CYS893 4.8 51.4 1.0
C A:CYS893 4.9 53.1 1.0
N A:GLU821 4.9 42.9 1.0
N A:SER895 4.9 47.9 1.0

Reference:

S.Pathuri, J.R.Horton, X.Zhang, X.Cheng. Human DNMT1(729-1600) Bound to Zebularine-Containing 12MER Dsdna and Inhibitor GSK3830052 To Be Published.
Page generated: Tue Oct 29 10:41:05 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy