Atomistry » Zinc » PDB 6woy-6x38 » 6wzw
Atomistry »
  Zinc »
    PDB 6woy-6x38 »
      6wzw »

Zinc in PDB 6wzw: ASH1L Set Domain in Complex with As-85

Enzymatic activity of ASH1L Set Domain in Complex with As-85

All present enzymatic activity of ASH1L Set Domain in Complex with As-85:
2.1.1.359;

Protein crystallography data

The structure of ASH1L Set Domain in Complex with As-85, PDB code: 6wzw was solved by H.Li, J.Deng, T.Cierpicki, J.Grembecka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.33 / 1.69
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 76.277, 31.998, 91.16, 90, 102.34, 90
R / Rfree (%) 16.4 / 20.6

Other elements in 6wzw:

The structure of ASH1L Set Domain in Complex with As-85 also contains other interesting chemical elements:

Fluorine (F) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the ASH1L Set Domain in Complex with As-85 (pdb code 6wzw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the ASH1L Set Domain in Complex with As-85, PDB code: 6wzw:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 6wzw

Go back to Zinc Binding Sites List in 6wzw
Zinc binding site 1 out of 3 in the ASH1L Set Domain in Complex with As-85


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of ASH1L Set Domain in Complex with As-85 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2303

b:13.5
occ:1.00
SG A:CYS2108 2.3 14.2 1.0
SG A:CYS2091 2.3 13.9 1.0
SG A:CYS2093 2.4 14.9 1.0
SG A:CYS2104 2.4 15.0 1.0
CB A:CYS2108 3.1 17.1 1.0
CB A:CYS2093 3.2 9.2 1.0
CB A:CYS2104 3.2 10.7 1.0
CB A:CYS2091 3.3 13.9 1.0
CA A:CYS2104 3.6 13.4 1.0
CA A:CYS2108 3.8 14.6 1.0
ZN A:ZN2304 3.9 13.9 1.0
SG A:CYS2117 4.2 14.0 1.0
O A:HOH2563 4.2 17.0 1.0
N A:CYS2093 4.3 14.0 1.0
CA A:CYS2093 4.3 12.7 1.0
N A:CYS2104 4.5 16.8 1.0
C A:CYS2108 4.6 15.9 1.0
CA A:CYS2091 4.7 15.7 1.0
N A:LEU2109 4.7 14.9 1.0
O A:HOH2591 4.7 15.7 1.0
C A:CYS2104 4.7 20.1 1.0
N A:ASN2092 5.0 18.6 1.0

Zinc binding site 2 out of 3 in 6wzw

Go back to Zinc Binding Sites List in 6wzw
Zinc binding site 2 out of 3 in the ASH1L Set Domain in Complex with As-85


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of ASH1L Set Domain in Complex with As-85 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2304

b:13.9
occ:1.00
SG A:CYS2122 2.2 13.2 1.0
SG A:CYS2128 2.3 12.7 1.0
SG A:CYS2104 2.3 15.0 1.0
SG A:CYS2117 2.4 14.0 1.0
CB A:CYS2117 3.1 15.7 1.0
CB A:CYS2104 3.3 10.7 1.0
CB A:CYS2128 3.3 11.6 1.0
CB A:CYS2122 3.4 11.5 1.0
ZN A:ZN2303 3.9 13.5 1.0
O A:HOH2591 4.1 15.7 1.0
CA A:CYS2128 4.3 12.9 1.0
NE2 A:GLN2131 4.5 15.5 1.0
SG A:CYS2091 4.5 13.9 1.0
CB A:ASN2130 4.6 12.8 1.0
CA A:CYS2122 4.6 12.3 1.0
CA A:CYS2117 4.6 14.7 1.0
CB A:CYS2124 4.7 13.3 1.0
SG A:CYS2108 4.7 14.2 1.0
CA A:CYS2104 4.7 13.4 1.0

Zinc binding site 3 out of 3 in 6wzw

Go back to Zinc Binding Sites List in 6wzw
Zinc binding site 3 out of 3 in the ASH1L Set Domain in Complex with As-85


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of ASH1L Set Domain in Complex with As-85 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2305

b:15.9
occ:1.00
SG A:CYS2268 2.3 15.1 1.0
SG A:CYS2275 2.3 14.1 1.0
SG A:CYS2270 2.4 15.9 1.0
SG A:CYS2220 2.4 16.9 1.0
CB A:CYS2275 3.2 15.7 1.0
CB A:CYS2268 3.3 17.1 1.0
CB A:CYS2270 3.3 15.0 1.0
CB A:CYS2220 3.4 10.4 1.0
CA A:CYS2275 3.6 15.3 1.0
N A:CYS2220 3.9 13.5 1.0
N A:CYS2270 4.0 15.2 1.0
N A:ARG2276 4.1 19.2 1.0
CA A:CYS2270 4.2 17.6 1.0
C A:CYS2275 4.3 22.7 1.0
CA A:CYS2220 4.3 10.9 1.0
O A:HOH2568 4.4 17.4 1.0
CA A:CYS2268 4.5 14.6 1.0
NE2 A:HIS2218 4.5 13.3 1.0
C A:CYS2268 4.5 17.5 1.0
CD2 A:HIS2218 4.6 12.2 1.0
O A:CYS2268 4.6 16.2 1.0
N A:GLY2277 4.7 18.2 1.0
N A:CYS2275 4.8 16.2 1.0
C A:SER2219 4.9 11.2 1.0
C A:CYS2270 5.0 16.8 1.0
N A:GLY2271 5.0 17.0 1.0
N A:LYS2269 5.0 12.6 1.0

Reference:

H.Li, J.Grembecka, T.Cierpicki. ASH1L Set Domain in Complex with As-85 To Be Published.
Page generated: Sat Apr 17 17:43:11 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy