Zinc in PDB 6vw0: Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex

All present enzymatic activity of Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex:
2.7.7.6;

The structure of Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex (pdb code 6vw0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex, PDB code: 6vw0:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2000 b:0.7 occ:1.00 SG D:CYS975 2.4 96.8 1.0 SG D:CYS978 2.4 96.4 1.0 SG D:CYS968 2.4 0.0 1.0 SG D:CYS891 2.4 96.9 1.0 CB D:CYS978 2.7 96.4 1.0 CB D:CYS975 2.8 96.8 1.0 CB D:CYS968 2.9 0.0 1.0 N D:CYS975 3.5 96.8 1.0 CB D:CYS891 3.5 96.9 1.0 CA D:CYS968 3.6 0.0 1.0 CA D:CYS975 3.7 96.8 1.0 N D:CYS978 3.8 96.4 1.0 CA D:CYS978 3.8 96.4 1.0 C D:CYS975 4.3 96.8 1.0 N D:CYS891 4.3 96.9 1.0 N D:ALA969 4.3 1.0 1.0 C D:CYS968 4.5 0.0 1.0 CA D:CYS891 4.6 96.9 1.0 C D:VAL974 4.7 90.4 1.0 N D:CYS968 4.7 0.0 1.0 OG1 D:THR977 4.8 92.3 1.0 O D:CYS975 4.8 96.8 1.0 N D:ALA976 4.9 89.4 1.0 C D:THR977 5.0 92.3 1.0 C D:CYS978 5.0 96.4 1.0 CG2 D:THR893 5.0 97.7 1.0 O D:SER964 5.0 96.9 1.0

Zinc binding site 2 out of 2 in the Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Mycobacterium Tuberculosis Rnap S456L Mutant Open Promoter Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2001 b:0.4 occ:1.00 N D:CYS62 2.2 0.5 1.0 SG D:CYS60 2.4 0.1 1.0 SG D:CYS78 2.4 0.6 1.0 SG D:CYS62 2.5 0.5 1.0 CB D:CYS78 2.5 0.6 1.0 CB D:CYS62 2.8 0.5 1.0 CA D:CYS62 2.9 0.5 1.0 N D:TYR61 3.0 0.1 1.0 CB D:CYS60 3.2 0.1 1.0 C D:TYR61 3.2 0.1 1.0 SG D:CYS75 3.5 0.6 1.0 C D:CYS62 3.5 0.5 1.0 N D:GLY63 3.6 0.3 1.0 C D:CYS60 3.6 0.1 1.0 CA D:TYR61 3.6 0.1 1.0 CA D:CYS78 3.8 0.6 1.0 CB D:CYS75 4.0 0.6 1.0 CA D:CYS60 4.0 0.1 1.0 N D:CYS78 4.1 0.6 1.0 CB D:TYR61 4.1 0.1 1.0 O D:CYS60 4.3 0.1 1.0 O D:TYR61 4.4 0.1 1.0 N D:LYS64 4.4 0.9 1.0 O D:CYS62 4.4 0.5 1.0 C D:CYS78 4.7 0.6 1.0 CA D:GLY63 4.8 0.3 1.0

M.Lilic, J.Chen, H.Boyaci, N.Braffman, E.A.Hubin, J.Herrmann, R.Muller, R.Mooney, R.Landick, S.A.Darst, E.A.Campbell. The Antibiotic Sorangicin A Inhibits Promoter Dna Unwinding in A Mycobacterium Tuberculosis Rifampicin-Resistant Rna Polymerase. Proc.Natl.Acad.Sci.Usa 2020.
ISSN: ESSN 1091-6490
PubMed: 33199626
DOI: 10.1073/PNAS.2013706117