Zinc in PDB 6vdo: Hcv NS3/4A Protease A156T, D168E Double Mutant

The structure of Hcv NS3/4A Protease A156T, D168E Double Mutant, PDB code: 6vdo was solved by J.Timm, C.A.Schiffer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.05 / 2.11
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	55.019, 58.587, 61.636, 90, 90, 90
R / Rfree (%)	19.4 / 23.5

The binding sites of Zinc atom in the Hcv NS3/4A Protease A156T, D168E Double Mutant (pdb code 6vdo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Hcv NS3/4A Protease A156T, D168E Double Mutant, PDB code: 6vdo:

Zinc binding site 1 out of 1 in the Hcv NS3/4A Protease A156T, D168E Double Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hcv NS3/4A Protease A156T, D168E Double Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1201 b:46.2 occ:1.00 ND1 A:HIS1149 2.1 49.4 1.0 SG A:CYS1097 2.3 34.8 1.0 SG A:CYS1145 2.4 42.6 1.0 SG A:CYS1099 2.4 53.0 1.0 HB2 A:HIS1149 2.7 45.3 1.0 HB2 A:CYS1145 2.7 49.1 1.0 HB3 A:CYS1145 2.9 49.1 1.0 CB A:CYS1145 2.9 40.7 1.0 CG A:HIS1149 3.1 45.6 1.0 CE1 A:HIS1149 3.1 50.9 1.0 HB2 A:CYS1097 3.2 44.3 1.0 H A:CYS1099 3.3 57.8 1.0 CB A:CYS1097 3.3 36.7 1.0 HE1 A:HIS1149 3.3 61.3 1.0 HB2 A:CYS1099 3.4 55.9 1.0 CB A:HIS1149 3.4 37.5 1.0 HA A:CYS1097 3.4 45.4 1.0 CB A:CYS1099 3.5 46.4 1.0 HB3 A:ALA1147 3.6 57.4 1.0 H A:THR1098 3.7 55.4 1.0 CA A:CYS1097 3.8 37.6 1.0 H A:HIS1149 3.9 46.6 1.0 HB3 A:HIS1149 3.9 45.3 1.0 N A:CYS1099 4.0 47.9 1.0 HD2 A:PRO1146 4.1 55.8 1.0 H A:ALA1147 4.1 57.1 1.0 HB3 A:CYS1097 4.1 44.3 1.0 N A:THR1098 4.2 46.0 1.0 NE2 A:HIS1149 4.2 53.7 1.0 CD2 A:HIS1149 4.3 45.6 1.0 HB3 A:CYS1099 4.3 55.9 1.0 CA A:CYS1145 4.4 37.2 1.0 CA A:CYS1099 4.4 52.4 1.0 C A:CYS1097 4.5 41.3 1.0 CB A:ALA1147 4.5 47.6 1.0 CA A:HIS1149 4.5 37.3 1.0 N A:HIS1149 4.6 38.6 1.0 HG22 A:VAL1151 4.8 33.6 1.0 H A:CYS1145 4.8 42.5 1.0 HA A:CYS1145 4.8 44.9 1.0 HB3 A:SER1101 4.9 53.5 1.0 N A:ALA1147 4.9 47.4 1.0 CD A:PRO1146 4.9 46.3 1.0 HB1 A:ALA1147 5.0 57.4 1.0 HB2 A:ALA1147 5.0 57.4 1.0

J.Timm, J.Zephyr, S.Hou, N.Kurt Yilmaz, C.A.Schiffer. Apo Structure of Hcv NS3/4A Protease A156T;D168E Double Mutant To Be Published.