Zinc in PDB 6ux2: Crystal Structure of Zikv Rdrp in Complex with STAT2

All present enzymatic activity of Crystal Structure of Zikv Rdrp in Complex with STAT2:
2.1.1.56; 2.1.1.57; 2.7.7.48; 3.4.21.91; 3.6.1.15; 3.6.4.13;

The structure of Crystal Structure of Zikv Rdrp in Complex with STAT2, PDB code: 6ux2 was solved by B.Wang, J.Song, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.24 / 3.01
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	85.113, 124.700, 84.783, 90.00, 109.39, 90.00
R / Rfree (%)	24.2 / 26.4

The binding sites of Zinc atom in the Crystal Structure of Zikv Rdrp in Complex with STAT2 (pdb code 6ux2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Zikv Rdrp in Complex with STAT2, PDB code: 6ux2:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Zikv Rdrp in Complex with STAT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Zikv Rdrp in Complex with STAT2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1002 b:61.1 occ:1.00 OE2 B:GLU439 2.1 63.6 1.0 NE2 B:HIS443 2.2 50.9 1.0 SG B:CYS448 2.3 53.2 1.0 SG B:CYS451 2.4 76.4 1.0 CD B:GLU439 3.0 59.1 1.0 CG B:GLU439 3.2 52.6 1.0 CE1 B:HIS443 3.2 55.5 1.0 CB B:CYS451 3.2 59.3 1.0 CD2 B:HIS443 3.2 62.9 1.0 N B:CYS451 3.5 62.0 1.0 CB B:CYS448 3.8 62.8 1.0 CA B:CYS451 4.0 60.0 1.0 CA B:CYS448 4.1 53.9 1.0 OE1 B:GLU439 4.1 57.8 1.0 N B:SER450 4.2 63.5 1.0 NH1 B:ARG281 4.3 52.4 1.0 ND1 B:HIS443 4.3 55.0 1.0 N B:HIS449 4.3 51.3 1.0 CG B:HIS443 4.3 63.3 1.0 C B:SER450 4.5 59.9 1.0 CD1 B:LEU485 4.6 56.5 1.0 C B:CYS448 4.6 53.7 1.0 CB B:GLU439 4.7 44.8 1.0 CA B:SER450 4.8 58.6 1.0 O B:GLU439 4.9 60.3 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Zikv Rdrp in Complex with STAT2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Zikv Rdrp in Complex with STAT2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1003 b:64.0 occ:1.00 NE2 B:HIS714 2.2 52.4 1.0 SG B:CYS849 2.3 58.0 1.0 SG B:CYS730 2.3 55.9 1.0 O B:HOH1124 2.3 58.0 1.0 CD2 B:HIS714 3.0 42.0 1.0 CB B:CYS849 3.3 66.5 1.0 CE1 B:HIS714 3.3 55.3 1.0 CB B:CYS730 3.4 52.8 1.0 NH1 B:ARG771 3.8 56.9 1.0 ND2 B:ASN716 3.8 48.4 1.0 CG B:HIS714 4.2 43.0 1.0 C B:CYS730 4.3 47.2 1.0 ND1 B:HIS714 4.3 48.9 1.0 N B:ARG731 4.4 47.3 1.0 CA B:CYS730 4.5 49.0 1.0 O B:ARG731 4.6 56.2 1.0 O B:CYS730 4.7 46.1 1.0 CZ B:ARG771 4.7 52.8 1.0 CA B:CYS849 4.7 61.1 1.0 CA B:ARG731 4.8 49.1 1.0 C B:ARG731 4.8 55.3 1.0 CG B:ASN716 4.9 50.5 1.0 CD2 B:LEU841 4.9 65.2 1.0 O B:GLU845 4.9 64.8 1.0

B.Wang, S.Thurmond, K.Zhou, M.T.Sanchez-Aparicio, J.Fang, J.Lu, L.Gao, W.Ren, Y.Cui, E.C.Veit, H.Hong, M.J.Evans, S.E.O'leary, A.Garcia-Sastre, Z.H.Zhou, R.Hai, J.Song. Structural Basis For STAT2 Suppression By Flavivirus NS5. Nat.Struct.Mol.Biol. V. 27 875 2020.
ISSN: ESSN 1545-9985
PubMed: 32778820
DOI: 10.1038/S41594-020-0472-Y