Zinc in PDB 6u7g: Hcov-229E Rbd Class V in Complex with Human Apn

All present enzymatic activity of Hcov-229E Rbd Class V in Complex with Human Apn:
3.4.11.2;

The structure of Hcov-229E Rbd Class V in Complex with Human Apn, PDB code: 6u7g was solved by A.Tomlinson, Z.Li, J.M.Rini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.61 / 2.35
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	99.555, 98.682, 147.525, 90.00, 104.60, 90.00
R / Rfree (%)	17.9 / 21.8

The binding sites of Zinc atom in the Hcov-229E Rbd Class V in Complex with Human Apn (pdb code 6u7g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Hcov-229E Rbd Class V in Complex with Human Apn, PDB code: 6u7g:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Hcov-229E Rbd Class V in Complex with Human Apn


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hcov-229E Rbd Class V in Complex with Human Apn within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn5001 b:21.8 occ:1.00 OE2 A:GLU411 1.9 30.4 1.0 NE2 A:HIS392 2.0 29.1 1.0 NE2 A:HIS388 2.1 26.0 1.0 O A:HOH5463 2.3 24.2 1.0 CD A:GLU411 2.7 30.0 1.0 CD2 A:HIS392 2.9 29.0 1.0 OE1 A:GLU411 3.0 29.2 1.0 HD2 A:HIS392 3.0 34.9 1.0 CD2 A:HIS388 3.0 25.5 1.0 CE1 A:HIS388 3.1 24.8 1.0 CE1 A:HIS392 3.1 29.2 1.0 HD2 A:HIS388 3.1 30.6 1.0 HE1 A:HIS388 3.3 29.7 1.0 HE2 A:TYR477 3.4 27.3 1.0 HE1 A:HIS392 3.4 35.0 1.0 HH A:TYR477 3.4 32.1 1.0 HB3 A:ALA414 3.6 29.4 1.0 HA A:GLU411 3.6 29.5 1.0 HB1 A:ALA414 3.9 29.4 1.0 CE2 A:TYR477 3.9 22.7 1.0 O A:HOH5109 4.0 35.0 1.0 OH A:TYR477 4.0 26.8 1.0 CB A:ALA414 4.1 24.4 1.0 CG A:HIS392 4.1 29.8 1.0 CG A:GLU411 4.1 28.9 1.0 ND1 A:HIS392 4.2 30.8 1.0 CG A:HIS388 4.2 25.3 1.0 ND1 A:HIS388 4.2 25.5 1.0 HB2 A:ALA414 4.2 29.4 1.0 HB3 A:GLU411 4.3 32.0 1.0 CZ A:TYR477 4.3 22.9 1.0 OE1 A:GLU355 4.3 28.1 1.0 CA A:GLU411 4.5 24.6 1.0 CB A:GLU411 4.5 26.6 1.0 HG3 A:GLU411 4.6 34.7 1.0 HG2 A:GLU411 4.7 34.7 1.0 OE1 A:GLU389 4.8 32.1 1.0 CD2 A:TYR477 4.9 22.7 1.0 CD A:GLU355 5.0 27.0 1.0 OE2 A:GLU355 5.0 28.9 1.0 O A:HOH5194 5.0 21.8 1.0 HD1 A:HIS392 5.0 37.0 1.0 HD1 A:HIS388 5.0 30.6 1.0

Zinc binding site 2 out of 2 in the Hcov-229E Rbd Class V in Complex with Human Apn


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Hcov-229E Rbd Class V in Complex with Human Apn within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn5001 b:21.6 occ:1.00 OE2 B:GLU411 1.9 22.3 1.0 NE2 B:HIS388 2.1 26.9 1.0 NE2 B:HIS392 2.1 20.9 1.0 O B:HOH5337 2.1 28.3 1.0 CD B:GLU411 2.8 27.5 1.0 OE1 B:GLU411 2.9 31.5 1.0 CD2 B:HIS388 3.0 28.4 1.0 CD2 B:HIS392 3.0 25.0 1.0 HD2 B:HIS388 3.1 34.1 1.0 CE1 B:HIS388 3.1 27.8 1.0 CE1 B:HIS392 3.1 25.4 1.0 HD2 B:HIS392 3.1 30.1 1.0 HE1 B:HIS388 3.3 33.4 1.0 HE1 B:HIS392 3.3 30.6 1.0 HA B:GLU411 3.6 27.9 1.0 HE1 B:TYR477 3.7 35.3 1.0 HB3 B:ALA414 3.7 28.8 1.0 HH B:TYR477 3.8 34.8 1.0 O B:HOH5256 4.0 36.7 1.0 CG B:HIS388 4.1 28.0 1.0 ND1 B:HIS388 4.2 28.2 1.0 CG B:HIS392 4.2 24.2 1.0 CG B:GLU411 4.2 28.1 1.0 HB1 B:ALA414 4.2 28.8 1.0 OE1 B:GLU355 4.2 34.8 1.0 ND1 B:HIS392 4.2 27.2 1.0 CB B:ALA414 4.3 24.0 1.0 CE1 B:TYR477 4.4 29.4 1.0 HB3 B:GLU411 4.4 34.7 1.0 OE2 B:GLU389 4.5 35.1 1.0 OH B:TYR477 4.5 29.0 1.0 HB2 B:ALA414 4.5 28.8 1.0 CA B:GLU411 4.5 23.3 1.0 CB B:GLU411 4.6 28.9 1.0 HG2 B:GLU411 4.7 33.7 1.0 HG3 B:GLU411 4.7 33.7 1.0 CD B:GLU355 4.7 34.7 1.0 CZ B:TYR477 4.8 27.3 1.0 OE2 B:GLU355 4.9 35.9 1.0 HB3 B:GLU355 4.9 36.7 1.0 HD1 B:HIS388 5.0 33.9 1.0 HD1 B:HIS392 5.0 32.7 1.0

Z.Li, A.C.A.Tomlinson, A.H.M.Wong, D.Zhou, M.Desforges, P.J.Talbot, S.Benlekbir, J.L.Rubinstein, J.M.Rini. The Human Coronavirus Hcov-229E S-Protein Structure and Receptor Binding. Elife V. 8 2019.
ISSN: ESSN 2050-084X
PubMed: 31650956
DOI: 10.7554/ELIFE.51230