Zinc in PDB 6skh: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp, PDB code: 6skh was solved by L.Motlova, Z.Novakova, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.21 / 1.58
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.629, 130.530, 159.192, 90.00, 90.00, 90.00
R / Rfree (%) 17.1 / 19.3

Other elements in 6skh:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp (pdb code 6skh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp, PDB code: 6skh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6skh

Go back to Zinc Binding Sites List in 6skh
Zinc binding site 1 out of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn820

b:20.1
occ:1.00
OD2 A:ASP387 2.0 21.5 1.0
OE2 A:GLU425 2.0 19.0 1.0
NE2 A:HIS553 2.0 19.1 1.0
O A:HOH1198 2.0 18.6 1.0
OE1 A:GLU425 2.4 19.0 1.0
CD A:GLU425 2.5 17.6 1.0
OAE A:LHK829 2.9 25.5 1.0
CG A:ASP387 2.9 21.2 1.0
CE1 A:HIS553 3.0 19.2 1.0
CD2 A:HIS553 3.1 20.8 1.0
OD1 A:ASP387 3.3 18.9 1.0
ZN A:ZN821 3.3 19.8 1.0
SAV A:LHK829 4.0 30.0 1.0
O A:HOH1022 4.0 20.3 1.0
NAO A:LHK829 4.0 26.4 1.0
CG A:GLU425 4.1 17.4 1.0
ND1 A:HIS553 4.1 19.6 1.0
CG A:HIS553 4.2 20.1 1.0
CE1 A:TYR552 4.2 21.8 1.0
CA A:LHK829 4.2 24.2 1.0
CB A:ASP387 4.3 21.0 1.0
NE2 A:HIS377 4.5 19.1 1.0
N A:LHK829 4.5 25.6 1.0
CAM A:LHK829 4.5 35.1 1.0
CD1 A:TRP381 4.5 20.2 1.0
CE1 A:HIS377 4.6 18.7 1.0
OH A:TYR552 4.6 23.4 1.0
NE1 A:TRP381 4.7 20.6 1.0
C A:LHK829 4.8 23.6 1.0
CZ A:TYR552 4.8 22.4 1.0
SD A:MET424 4.8 20.2 1.0
OXT A:LHK829 4.8 22.5 1.0
CAU A:LHK829 4.9 32.9 1.0
OD2 A:ASP453 5.0 19.1 1.0

Zinc binding site 2 out of 2 in 6skh

Go back to Zinc Binding Sites List in 6skh
Zinc binding site 2 out of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn821

b:19.8
occ:1.00
O A:HOH1198 1.8 18.6 1.0
OD1 A:ASP387 2.0 18.9 1.0
NE2 A:HIS377 2.0 19.1 1.0
OD2 A:ASP453 2.0 19.1 1.0
OD1 A:ASP453 2.6 21.7 1.0
CG A:ASP453 2.6 19.6 1.0
CG A:ASP387 2.9 21.2 1.0
CE1 A:HIS377 3.0 18.7 1.0
CD2 A:HIS377 3.0 18.8 1.0
OD2 A:ASP387 3.3 21.5 1.0
ZN A:ZN820 3.3 20.1 1.0
NAO A:LHK829 3.6 26.4 1.0
OE2 A:GLU425 3.8 19.0 1.0
CE A:MET424 3.9 18.9 1.0
SD A:MET424 4.1 20.2 1.0
CAU A:LHK829 4.1 32.9 1.0
OAH A:LHK829 4.1 38.2 1.0
ND1 A:HIS377 4.1 19.4 1.0
CB A:ASP453 4.1 19.2 1.0
CG A:HIS377 4.2 18.0 1.0
CB A:ASP387 4.2 21.0 1.0
CB A:PRO388 4.3 19.4 1.0
CAM A:LHK829 4.4 35.1 1.0
CD A:GLU425 4.4 17.6 1.0
ND2 A:ASN519 4.5 18.7 1.0
CA A:PRO388 4.5 18.9 1.0
CA A:ASP387 4.6 20.9 1.0
C A:ASP387 4.6 21.0 1.0
N A:PRO388 4.6 19.6 1.0
CAQ A:LHK829 4.6 35.9 1.0
OE1 A:GLU425 4.7 19.0 1.0
OG A:SER454 4.7 18.5 0.8
OAE A:LHK829 4.7 25.5 1.0
SAV A:LHK829 4.8 30.0 1.0

Reference:

L.Motlova, Z.Novakova, C.Barinka. X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor Sulfamide Inhibitor Gluasp To Be Published.
Page generated: Wed Dec 16 12:48:47 2020

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