Zinc in PDB 6siv: Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif

The structure of Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif, PDB code: 6siv was solved by I.P.Suarez, A.Cousido-Siah, A.Bonhoure, A.Mitschler, A.Podjarny, G.Trave, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.52 / 1.75
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	97.031, 132.467, 42.634, 90.00, 90.00, 90.00
R / Rfree (%)	18.2 / 22

The binding sites of Zinc atom in the Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif (pdb code 6siv). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif, PDB code: 6siv:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1200 b:32.2 occ:1.00 SG B:CYS1136 2.3 36.5 1.0 SG B:CYS1106 2.3 30.8 1.0 SG B:CYS1139 2.3 39.0 1.0 SG B:CYS1103 2.3 32.6 1.0 CB B:CYS1103 3.2 31.1 1.0 CB B:CYS1106 3.2 32.6 1.0 CB B:CYS1139 3.2 47.4 1.0 CB B:CYS1136 3.4 32.8 1.0 N B:CYS1106 3.8 36.5 1.0 N B:CYS1136 4.0 35.8 1.0 CA B:CYS1106 4.1 31.6 1.0 N B:CYS1139 4.1 43.1 1.0 O B:HOH1352 4.2 47.3 1.0 CA B:CYS1136 4.2 37.0 1.0 CA B:CYS1139 4.3 46.0 1.0 O B:HOH1357 4.4 42.1 1.0 CE B:LYS1108 4.6 38.1 1.0 CA B:CYS1103 4.6 29.6 1.0 O B:CYS1136 4.7 36.6 1.0 CB B:ASN1105 4.7 38.8 1.0 C B:CYS1136 4.8 38.6 1.0 C B:ASN1105 4.8 38.4 1.0 C B:CYS1106 4.9 35.2 1.0 NZ B:LYS1108 4.9 45.6 1.0

Zinc binding site 2 out of 2 in the Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of HPV16 E6 Oncoprotein in Complex with Mutant IRF3 Lxxll Motif within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1201 b:25.0 occ:1.00 SG B:CYS1063 2.2 25.8 1.0 SG B:CYS1030 2.3 23.1 1.0 SG B:CYS1066 2.3 25.0 1.0 SG B:CYS1033 2.4 25.4 1.0 CB B:CYS1066 3.1 23.9 1.0 CB B:CYS1030 3.1 19.4 1.0 CB B:CYS1033 3.3 22.5 1.0 CB B:CYS1063 3.6 23.4 1.0 N B:CYS1033 3.7 24.2 1.0 N B:CYS1063 4.1 20.0 1.0 CA B:CYS1033 4.1 26.4 1.0 N B:CYS1066 4.2 25.8 1.0 CA B:CYS1066 4.2 24.3 1.0 CA B:CYS1063 4.3 20.4 1.0 CB B:TYR1032 4.6 23.7 1.0 O B:HOH1364 4.6 30.7 1.0 CA B:CYS1030 4.6 22.7 1.0 C B:TYR1032 4.8 27.9 1.0 O B:CYS1063 4.8 22.6 1.0 C B:CYS1063 4.9 21.9 1.0 C B:CYS1033 4.9 26.4 1.0

J.Poirson, I.P.Suarez, A.Cousido-Siah, A.Forster, Y.Chebaro, A.Mitschler, M.Straub, D.Altschuh, A.Podjarny, G.Trave, M.Masson. Deciphering the Molecular and Structural Interaction Between IRF3 and HPV16 E6 To Be Published.