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Zinc in PDB 6ruj: Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide:
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide, PDB code: 6ruj was solved by Y.Nakashima, M.A.Mcdonough, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.04 / 2.42
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.401, 86.401, 147.263, 90.00, 90.00, 90.00
R / Rfree (%) 20.9 / 25.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide (pdb code 6ruj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide, PDB code: 6ruj:

Zinc binding site 1 out of 1 in 6ruj

Go back to Zinc Binding Sites List in 6ruj
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-(D)3-Hydroxy-Leu Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:58.7
occ:1.00
NE2 A:HIS199 2.0 63.4 1.0
OD2 A:ASP201 2.1 56.4 1.0
NE2 A:HIS279 2.2 55.8 1.0
O2' A:OGA502 2.2 58.7 1.0
O2 A:OGA502 2.3 58.7 1.0
C2 A:OGA502 2.8 58.7 1.0
C1 A:OGA502 2.8 58.7 1.0
OE B:KJW803 2.8 80.4 1.0
HE B:KJW803 2.8 47.5 1.0
CE1 A:HIS199 2.9 65.6 1.0
HE1 A:HIS199 3.0 0.5 1.0
CD2 A:HIS279 3.1 57.0 1.0
CD2 A:HIS199 3.1 62.3 1.0
CG A:ASP201 3.1 56.0 1.0
HD2 A:HIS279 3.2 0.0 1.0
HZ2 A:TRP296 3.2 0.5 1.0
HG B:KJW803 3.2 87.2 1.0
CE1 A:HIS279 3.3 54.4 1.0
HD2 A:HIS199 3.3 0.2 1.0
OD1 A:ASP201 3.4 56.0 1.0
HE1 A:HIS279 3.5 0.3 1.0
HD22 B:KJW803 3.9 87.2 1.0
O A:HOH605 3.9 67.2 1.0
CG B:KJW803 4.0 84.5 1.0
O1 A:OGA502 4.0 58.7 1.0
ND1 A:HIS199 4.0 66.3 1.0
CB B:KJW803 4.0 84.6 1.0
CZ2 A:TRP296 4.1 62.6 1.0
CG A:HIS199 4.2 63.9 1.0
N1 A:OGA502 4.2 58.7 1.0
CG A:HIS279 4.3 55.7 1.0
HB3 B:KJW803 4.3 87.2 1.0
ND1 A:HIS279 4.3 54.0 1.0
HD22 A:ASN205 4.3 0.1 1.0
CD2 B:KJW803 4.4 84.1 1.0
CB A:ASP201 4.5 56.0 1.0
HB2 A:ASP201 4.5 0.3 1.0
HE1 A:TRP296 4.6 0.8 1.0
H B:KJW803 4.6 47.5 1.0
H4C2 A:OGA502 4.6 58.7 1.0
HD21 B:KJW803 4.7 87.2 1.0
H1 A:OGA502 4.8 58.7 1.0
HH2 A:TRP296 4.8 0.4 1.0
HD1 A:HIS199 4.8 0.1 1.0
CH2 A:TRP296 5.0 62.9 1.0
HD12 A:ILE281 5.0 0.4 1.0
C4 A:OGA502 5.0 58.7 1.0
HB3 A:ASP201 5.0 0.3 1.0

Reference:

H.Choi, A.Hardy, T.M.Leissing, R.Chowdhury, W.Ge, M.Markoulides, J.S.Scotti, H.Thorbjornsrud, Y.Nakashima, D.Kang, S.Hong, J.Lee, H.Park, M.A.Mcdonough, C.J.Schofield. A Human Protein Hydroxylase That Accepts D-Residues Commun Chem 2020.
ISSN: ESSN 2399-3669
DOI: 10.1038/S42004-020-0290-5
Page generated: Wed Dec 16 12:42:32 2020

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