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Zinc in PDB 6rry: Golgi Alpha-Mannosidase II in Complex with (2S,3R)-2-(Hydroxymethyl)- 1,2,3,6-Tetrahydro-3-PyridinolEnzymatic activity of Golgi Alpha-Mannosidase II in Complex with (2S,3R)-2-(Hydroxymethyl)- 1,2,3,6-Tetrahydro-3-Pyridinol
All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with (2S,3R)-2-(Hydroxymethyl)- 1,2,3,6-Tetrahydro-3-Pyridinol:
3.2.1.114; Protein crystallography data
The structure of Golgi Alpha-Mannosidase II in Complex with (2S,3R)-2-(Hydroxymethyl)- 1,2,3,6-Tetrahydro-3-Pyridinol, PDB code: 6rry
was solved by
Z.Armstrong,
D.Lahav,
R.Johnson,
C.L.Kuo,
T.J.M.Beenakker,
C.De Boer,
C.S.Wong,
E.R.Van Rijssel,
M.Debets,
P.P.Geurink,
H.Ovaa,
M.Van Derstelt,
J.D.C.Codee,
J.M.F.G.Aerts,
L.Wu,
H.S.Overkleeft,
G.J.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with (2S,3R)-2-(Hydroxymethyl)- 1,2,3,6-Tetrahydro-3-Pyridinol
(pdb code 6rry). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with (2S,3R)-2-(Hydroxymethyl)- 1,2,3,6-Tetrahydro-3-Pyridinol, PDB code: 6rry: Zinc binding site 1 out of 1 in 6rryGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Golgi Alpha-Mannosidase II in Complex with (2S,3R)-2-(Hydroxymethyl)- 1,2,3,6-Tetrahydro-3-Pyridinol
![]() Mono view ![]() Stereo pair view
Reference:
Z.Armstrong,
D.Lahav,
R.Johnson,
C.L.Kuo,
T.J.M.Beenakker,
C.De Boer,
C.S.Wong,
E.R.Van Rijssel,
M.Debets,
P.P.Geurink,
H.Ovaa,
M.Van Der Stelt,
J.D.C.Codee,
J.M.F.G.Aerts,
L.Wu,
H.S.Overkleeft,
G.J.Davies.
Manno-Configured Epi-Cyclophellitol Aziridine Based Fluorescence Polarization Activity-Based Protein Profiling Identifies New Golgi A-Mannosidase Inhibitors To Be Published.
Page generated: Wed Dec 16 12:42:20 2020
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