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Zinc in PDB 6rru: Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol
Enzymatic activity of Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol
All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol:
3.2.1.114;
3.2.1.114;
Protein crystallography data
The structure of Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol, PDB code: 6rru
was solved by
Z.Armstrong,
D.Lahav,
R.Johnson,
C.L.Kuo,
T.J.M.Beenakker,
C.De Boer,
C.S.Wong,
E.R.Van Rijssel,
M.Debets,
P.P.Geurink,
H.Ovaa,
M.Van Derstelt,
J.D.C.Codee,
J.M.F.G.Aerts,
L.Wu,
H.S.Overkleeft,
G.J.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 75.51 / 1.90 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 88.959, 91.908, 131.835, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.2 / 24.2 |
Zinc Binding Sites:
The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol
(pdb code 6rru). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol, PDB code: 6rru:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol, PDB code: 6rru:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 6rru
Go back to
Zinc Binding Sites List in 6rru
Zinc binding site 1 out
of 2 in the Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol within 5.0Å range:
|
Zinc binding site 2 out of 2 in 6rru
Go back to
Zinc Binding Sites List in 6rru
Zinc binding site 2 out
of 2 in the Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Golgi Alpha-Mannosidase II in Complex with (5R,6R,7S,8S)-5,6,7,8- Tetrahydro-5-(Hydroxymethyl)-3-(3-Phenylpropyl)Imidazo[1,2- A]Pyridine-6,7,8-Triol within 5.0Å range:
|
Reference:
Z.Armstrong,
D.Lahav,
R.Johnson,
C.L.Kuo,
T.J.M.Beenakker,
C.De Boer,
C.S.Wong,
E.R.Van Rijssel,
M.Debets,
P.P.Geurink,
H.Ovaa,
M.Van Der Stelt,
J.D.C.Codee,
J.M.F.G.Aerts,
L.Wu,
H.S.Overkleeft,
G.J.Davies.
Manno-Configured Epi-Cyclophellitol Aziridine Based Fluorescence Polarization Activity-Based Protein Profiling Identifies New Golgi A-Mannosidase Inhibitors To Be Published.
Page generated: Tue Oct 29 06:44:53 2024
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