Zinc in PDB 6rqz: Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine

Enzymatic activity of Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine

All present enzymatic activity of Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine:
3.2.1.114;

Protein crystallography data

The structure of Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine, PDB code: 6rqz was solved by Z.Armstrong, D.Lahav, R.Johnson, C.L.Kuo, T.J.M.Beenakker, C.De Boer, C.S.Wong, M.Debets, M.Van Der Stelt, J.D.C.Codee, J.M.F.G.Aerts, L.Wu, H.S.Overkleeft, G.J.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 81.30 / 1.53
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 75.620, 89.989, 82.932, 90.00, 101.84, 90.00
R / Rfree (%) 15.6 / 18.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine (pdb code 6rqz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine, PDB code: 6rqz:

Zinc binding site 1 out of 1 in 6rqz

Go back to Zinc Binding Sites List in 6rqz
Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II Complex with Manno-Epi-Cyclophellitol Aziridine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1211

b:19.2
occ:1.00
OD1 A:ASP92 2.0 18.2 1.0
NE2 A:HIS90 2.1 17.8 1.0
NE2 A:HIS471 2.1 15.1 1.0
O6 A:KGH1210 2.1 17.9 1.0
O5 A:KGH1210 2.2 17.3 1.0
OD1 A:ASP204 2.6 19.6 1.0
C5 A:KGH1210 3.0 20.0 1.0
CG A:ASP92 3.0 18.5 1.0
CD2 A:HIS90 3.1 17.6 1.0
CD2 A:HIS471 3.1 16.0 1.0
CE1 A:HIS90 3.1 16.7 1.0
C6 A:KGH1210 3.1 20.7 1.0
CE1 A:HIS471 3.2 16.9 1.0
OD2 A:ASP92 3.3 19.8 1.0
C4 A:KGH1210 3.3 21.7 1.0
CG A:ASP204 3.5 19.8 1.0
CB A:ASP204 3.7 18.0 1.0
OD2 A:ASP472 4.0 17.2 1.0
C1 A:KGH1210 4.2 19.7 1.0
CG A:HIS90 4.2 17.9 1.0
ND1 A:HIS90 4.2 17.2 1.0
ND1 A:HIS471 4.3 15.8 1.0
CE1 A:HIS470 4.3 17.3 1.0
CG A:HIS471 4.3 15.3 1.0
CB A:ASP92 4.4 16.9 1.0
O A:HOH1560 4.5 18.9 1.0
OD2 A:ASP204 4.6 19.1 1.0
C3 A:KGH1210 4.7 22.5 1.0
CA A:ASP92 4.8 17.5 1.0
NE2 A:HIS470 4.9 17.1 1.0

Reference:

Z.Armstrong, D.Lahav, R.Johnson, C.L.Kuo, T.J.M.Beenakker, C.De Boer, C.S.Wong, M.Debets, M.Van Der Stelt, J.D.C.Codee, J.M.F.G.Aerts, L.Wu, H.S.Overkleeft, G.J.Davies. Manno-Configured Epi-Cyclophellitol Aziridine Based Fluorescence Polarization Activity-Based Protein Profiling Identifies New Golgi A-Mannosidase Inhibitors To Be Published.
Page generated: Wed Dec 16 12:41:30 2020

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