Zinc in PDB 6r7i: Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome

The binding sites of Zinc atom in the Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome (pdb code 6r7i). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome, PDB code: 6r7i:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn401 b:0.3 occ:1.00 O E:ARG106 2.0 0.2 1.0 OG1 E:THR154 2.0 0.0 1.0 O E:ILE150 2.2 0.2 1.0 OD1 E:ASP151 2.2 0.1 1.0 CA E:ASP151 2.3 0.3 1.0 C E:ILE150 2.3 0.5 1.0 N E:ASP151 2.3 0.6 1.0 CG E:ASP151 2.9 0.4 1.0 CB E:ASP151 3.1 0.2 1.0 C E:ARG106 3.2 0.8 1.0 CB E:THR154 3.2 0.3 1.0 CG2 E:ILE150 3.3 0.2 1.0 N E:ASN108 3.3 0.1 1.0 C E:ASP151 3.5 0.7 1.0 CA E:ILE150 3.6 0.8 1.0 CB E:ILE150 3.7 0.9 1.0 N E:THR154 3.8 0.6 1.0 CA E:VAL107 3.9 0.3 1.0 OD2 E:ASP151 3.9 0.8 1.0 N E:VAL107 3.9 0.4 1.0 CD N:LYS122 4.0 69.1 1.0 CA E:THR154 4.1 0.2 1.0 C E:VAL107 4.1 0.2 1.0 O E:ASP151 4.2 0.9 1.0 N E:ARG106 4.2 0.1 1.0 CA E:ASN108 4.2 0.4 1.0 CG2 E:THR154 4.2 0.1 1.0 CA E:ARG106 4.3 0.9 1.0 N E:VAL152 4.3 0.6 1.0 N E:ALA109 4.5 0.5 1.0 N E:ILE150 4.6 0.8 1.0 NZ N:LYS122 4.6 71.3 1.0 C E:THR105 4.7 0.7 1.0 CE N:LYS122 4.9 70.3 1.0 C E:ASN108 4.9 0.9 1.0 C E:SER153 5.0 0.0 1.0 CB E:ARG106 5.0 0.5 1.0 CG N:LYS122 5.0 67.4 1.0

Zinc binding site 2 out of 4 in the Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome within 5.0Å range: probe atom residue distance (Å) B Occ R:Zn201 b:0.4 occ:1.00 OD2 R:ASP51 1.9 0.9 1.0 CA R:CYS53 2.3 0.1 1.0 CB R:ASN47 2.3 0.7 1.0 CG R:ASN47 2.4 0.3 1.0 ND2 R:ASN47 2.5 0.6 1.0 C R:CYS53 2.8 0.2 1.0 O R:LEU52 2.8 0.0 1.0 N R:ILE54 3.0 0.0 1.0 CG R:ASP51 3.1 0.2 1.0 OD1 R:ASN47 3.1 0.3 1.0 N R:CYS53 3.2 0.1 1.0 C R:LEU52 3.3 0.7 1.0 CB R:CYS53 3.4 0.8 1.0 OD1 R:ASP51 3.6 0.9 1.0 CA R:ASN47 3.6 0.3 1.0 O R:CYS53 3.7 0.4 1.0 CA R:ILE54 4.2 0.3 1.0 CB R:ASP51 4.3 0.9 1.0 C R:ASN47 4.3 0.8 1.0 CG1 R:ILE54 4.4 0.5 1.0 O R:ASN47 4.7 0.0 1.0 CA R:LEU52 4.7 0.3 1.0 N R:ASN47 4.8 0.5 1.0 CB R:ILE54 4.9 0.1 1.0 SG R:CYS53 4.9 0.4 1.0 N R:HIS48 4.9 0.1 1.0 N R:LEU52 4.9 0.4 1.0 C R:ASP51 5.0 0.7 1.0

Zinc binding site 3 out of 4 in the Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome within 5.0Å range: probe atom residue distance (Å) B Occ R:Zn202 b:0.9 occ:1.00 O R:THR69 2.0 0.6 1.0 O R:ALA78 2.1 0.3 1.0 CD1 R:ILE49 2.3 0.8 1.0 CB R:THR69 2.4 0.2 1.0 C R:THR69 2.7 0.9 1.0 CA R:THR69 2.8 0.1 1.0 C R:ALA78 2.9 0.1 1.0 N R:THR69 3.2 0.8 1.0 CG2 R:THR69 3.2 0.9 1.0 CG1 R:ILE49 3.2 0.0 1.0 CB R:CYS42 3.2 0.0 1.0 OG1 R:THR69 3.5 0.5 1.0 CB R:ALA78 3.5 0.3 1.0 N R:PHE79 3.7 1.0 1.0 CD2 R:HIS80 3.7 0.3 1.0 CA R:ALA78 3.8 0.8 1.0 N R:VAL70 4.0 0.6 1.0 CA R:PHE79 4.1 0.7 1.0 NE2 R:HIS80 4.1 0.5 1.0 SG R:CYS42 4.1 0.6 1.0 CA R:CYS42 4.2 0.8 1.0 C R:CYS68 4.2 0.3 1.0 C R:PHE79 4.4 0.3 1.0 N R:CYS42 4.4 0.2 1.0 CB R:ILE49 4.4 0.7 1.0 N R:HIS80 4.4 0.1 1.0 CA R:VAL70 4.7 0.8 1.0 O R:CYS68 4.8 0.5 1.0 CG R:HIS80 4.8 0.4 1.0 CG2 R:VAL70 4.8 0.2 1.0 N R:ALA78 4.9 0.3 1.0

Zinc binding site 4 out of 4 in the Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structural Basis of Cullin-2 Ring E3 Ligase Regulation By the COP9 Signalosome within 5.0Å range: probe atom residue distance (Å) B Occ R:Zn203 b:0.4 occ:1.00 ND1 R:HIS82 2.1 1.0 1.0 CG R:HIS82 2.7 0.6 1.0 CB R:HIS82 3.0 1.0 1.0 CE1 R:HIS82 3.0 0.2 1.0 N R:HIS82 3.6 0.3 1.0 CD2 R:HIS82 3.7 0.8 1.0 NE2 R:HIS82 3.8 0.7 1.0 CA R:HIS82 3.9 0.9 1.0 ND2 R:ASN59 4.1 0.8 1.0 CB R:PHE81 4.3 0.5 1.0 C R:PHE81 4.3 0.8 1.0 O R:PHE81 4.9 0.9 1.0 CA R:PHE81 5.0 0.6 1.0 CG R:ASN59 5.0 0.0 1.0

S.V.Faull, A.M.C.Lau, C.Martens, Z.Ahdash, K.Hansen, H.Yebenes, C.Schmidt, F.Beuron, N.B.Cronin, E.P.Morris, A.Politis. Structural Basis of Cullin 2 Ring E3 Ligase Regulation By the COP9 Signalosome. Nat Commun V. 10 3814 2019.
ISSN: ESSN 2041-1723
PubMed: 31444342
DOI: 10.1038/S41467-019-11772-Y