Zinc in PDB 6qaj: Structure of the Tripartite Motif of KAP1/TRIM28
Enzymatic activity of Structure of the Tripartite Motif of KAP1/TRIM28
All present enzymatic activity of Structure of the Tripartite Motif of KAP1/TRIM28:
2.3.2.27;
3.2.1.17;
Protein crystallography data
The structure of Structure of the Tripartite Motif of KAP1/TRIM28, PDB code: 6qaj
was solved by
G.A.Stoll,
S.Oda,
M.Yu,
Y.Modis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
62.80 /
2.90
|
|
Space group
|
C 2 2 21
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
59.774,
169.332,
374.508,
90.00,
90.00,
90.00
|
|
R / Rfree (%)
|
26.1 /
29.1
|
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of the Tripartite Motif of KAP1/TRIM28
(pdb code 6qaj). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the
Structure of the Tripartite Motif of KAP1/TRIM28, PDB code: 6qaj:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Zinc binding site 1 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 1 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn500
b:79.2
occ:1.00
|
SG
|
A:CYS68
|
2.3
|
0.9
|
1.0
|
|
SG
|
A:CYS88
|
2.3
|
0.8
|
1.0
|
|
SG
|
A:CYS91
|
2.5
|
0.9
|
1.0
|
|
SG
|
A:CYS65
|
2.5
|
88.2
|
1.0
|
|
H
|
A:CYS68
|
3.1
|
0.2
|
1.0
|
|
HB2
|
A:CYS88
|
3.2
|
0.9
|
1.0
|
|
H
|
A:CYS88
|
3.4
|
0.8
|
1.0
|
|
HB3
|
A:CYS68
|
3.4
|
0.8
|
1.0
|
|
CB
|
A:CYS88
|
3.4
|
0.6
|
1.0
|
|
CB
|
A:CYS68
|
3.5
|
0.6
|
1.0
|
|
HB
|
A:VAL67
|
3.5
|
0.7
|
1.0
|
|
HB2
|
A:CYS65
|
3.6
|
99.5
|
1.0
|
|
HB2
|
A:CYS91
|
3.6
|
0.3
|
1.0
|
|
CB
|
A:CYS65
|
3.6
|
82.8
|
1.0
|
|
CB
|
A:CYS91
|
3.7
|
0.9
|
1.0
|
|
HB3
|
A:CYS65
|
3.8
|
99.5
|
1.0
|
|
N
|
A:CYS68
|
3.8
|
0.3
|
1.0
|
|
HB3
|
A:CYS91
|
4.0
|
0.3
|
1.0
|
|
N
|
A:CYS88
|
4.0
|
86.5
|
1.0
|
|
NH2
|
A:ARG76
|
4.1
|
0.7
|
1.0
|
|
HH22
|
A:ARG76
|
4.1
|
0.7
|
1.0
|
|
HB3
|
A:CYS88
|
4.1
|
0.9
|
1.0
|
|
CZ
|
A:ARG76
|
4.2
|
0.6
|
1.0
|
|
CA
|
A:CYS68
|
4.2
|
0.0
|
1.0
|
|
HB2
|
A:CYS68
|
4.3
|
0.8
|
1.0
|
|
HB2
|
A:GLU70
|
4.3
|
0.3
|
1.0
|
|
HH21
|
A:ARG76
|
4.3
|
0.7
|
1.0
|
|
CA
|
A:CYS88
|
4.4
|
89.3
|
1.0
|
|
NH1
|
A:ARG76
|
4.4
|
0.3
|
1.0
|
|
HH12
|
A:ARG76
|
4.4
|
0.3
|
1.0
|
|
CB
|
A:VAL67
|
4.5
|
97.2
|
1.0
|
|
H
|
A:GLU70
|
4.5
|
0.6
|
1.0
|
|
H
|
A:VAL67
|
4.5
|
0.3
|
1.0
|
|
HD3
|
A:ARG76
|
4.6
|
0.8
|
1.0
|
|
NE
|
A:ARG76
|
4.7
|
0.3
|
1.0
|
|
HG23
|
A:VAL67
|
4.7
|
0.4
|
1.0
|
|
HA
|
A:ALA87
|
4.8
|
94.2
|
1.0
|
|
H
|
A:ARG69
|
4.8
|
0.1
|
1.0
|
|
HH11
|
A:ARG76
|
4.8
|
0.3
|
1.0
|
|
C
|
A:CYS68
|
4.9
|
0.6
|
1.0
|
|
H
|
A:CYS91
|
4.9
|
0.1
|
1.0
|
|
HD23
|
A:LEU72
|
4.9
|
97.9
|
1.0
|
|
C
|
A:VAL67
|
4.9
|
0.8
|
1.0
|
|
HA
|
A:CYS88
|
5.0
|
0.2
|
1.0
|
|
HB1
|
A:ALA87
|
5.0
|
0.1
|
1.0
|
|
Zinc binding site 2 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 2 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn501
b:61.6
occ:1.00
|
ND1
|
A:HIS85
|
2.0
|
56.8
|
1.0
|
|
SG
|
A:CYS83
|
2.3
|
93.1
|
1.0
|
|
SG
|
A:CYS120
|
2.3
|
59.1
|
1.0
|
|
SG
|
A:CYS117
|
2.4
|
64.5
|
1.0
|
|
HB2
|
A:CYS83
|
2.7
|
60.5
|
1.0
|
|
CE1
|
A:HIS85
|
2.8
|
52.6
|
1.0
|
|
HE1
|
A:HIS85
|
2.8
|
63.2
|
1.0
|
|
HG23
|
A:VAL119
|
3.0
|
79.0
|
1.0
|
|
CB
|
A:CYS83
|
3.0
|
50.4
|
1.0
|
|
H
|
A:CYS120
|
3.2
|
80.2
|
1.0
|
|
CG
|
A:HIS85
|
3.2
|
59.5
|
1.0
|
|
HB2
|
A:HIS85
|
3.2
|
72.5
|
1.0
|
|
HB3
|
A:CYS83
|
3.4
|
60.5
|
1.0
|
|
HB3
|
A:CYS117
|
3.4
|
0.4
|
1.0
|
|
CB
|
A:CYS117
|
3.4
|
0.9
|
1.0
|
|
HB3
|
A:CYS120
|
3.4
|
70.4
|
1.0
|
|
CB
|
A:CYS120
|
3.5
|
58.6
|
1.0
|
|
HB2
|
A:CYS117
|
3.6
|
0.4
|
1.0
|
|
HG22
|
A:VAL119
|
3.6
|
79.0
|
1.0
|
|
CG2
|
A:VAL119
|
3.6
|
65.8
|
1.0
|
|
CB
|
A:HIS85
|
3.8
|
60.4
|
1.0
|
|
HG21
|
A:VAL119
|
3.9
|
79.0
|
1.0
|
|
N
|
A:CYS120
|
3.9
|
66.8
|
1.0
|
|
NE2
|
A:HIS85
|
4.0
|
52.9
|
1.0
|
|
H
|
A:HIS85
|
4.1
|
61.6
|
1.0
|
|
CD2
|
A:HIS85
|
4.2
|
65.8
|
1.0
|
|
CA
|
A:CYS120
|
4.3
|
63.6
|
1.0
|
|
HB2
|
A:CYS120
|
4.3
|
70.4
|
1.0
|
|
HB3
|
A:GLN122
|
4.3
|
69.9
|
1.0
|
|
CA
|
A:CYS83
|
4.3
|
47.6
|
1.0
|
|
H
|
A:VAL119
|
4.4
|
89.5
|
1.0
|
|
HB3
|
A:HIS85
|
4.4
|
72.5
|
1.0
|
|
O
|
A:CYS83
|
4.4
|
44.6
|
1.0
|
|
H
|
A:GLN122
|
4.5
|
77.1
|
1.0
|
|
C
|
A:CYS83
|
4.6
|
45.9
|
1.0
|
|
HE2
|
A:HIS85
|
4.7
|
63.6
|
1.0
|
|
HB2
|
A:LEU81
|
4.7
|
74.5
|
1.0
|
|
H
|
A:LYS121
|
4.7
|
96.9
|
1.0
|
|
N
|
A:HIS85
|
4.7
|
51.3
|
1.0
|
|
H
|
A:CYS83
|
4.7
|
60.2
|
1.0
|
|
CA
|
A:CYS117
|
4.9
|
72.4
|
1.0
|
|
C
|
A:CYS120
|
4.9
|
65.3
|
1.0
|
|
CA
|
A:HIS85
|
4.9
|
54.9
|
1.0
|
|
HD13
|
A:LEU81
|
4.9
|
81.6
|
1.0
|
|
HA
|
A:CYS83
|
4.9
|
57.2
|
1.0
|
|
C
|
A:VAL119
|
5.0
|
68.5
|
1.0
|
|
CB
|
A:VAL119
|
5.0
|
70.1
|
1.0
|
|
Zinc binding site 3 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 3 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn502
b:0.2
occ:1.00
|
ND1
|
A:HIS212
|
2.0
|
0.4
|
1.0
|
|
SG
|
A:CYS229
|
2.3
|
0.4
|
1.0
|
|
SG
|
A:CYS209
|
2.3
|
0.8
|
1.0
|
|
SG
|
A:CYS232
|
2.3
|
0.2
|
1.0
|
|
CE1
|
A:HIS212
|
2.8
|
0.6
|
1.0
|
|
HE1
|
A:HIS212
|
2.8
|
0.3
|
1.0
|
|
CG
|
A:HIS212
|
3.2
|
0.4
|
1.0
|
|
HB2
|
A:HIS212
|
3.2
|
0.9
|
1.0
|
|
HG23
|
A:VAL211
|
3.4
|
0.8
|
1.0
|
|
H
|
A:CYS232
|
3.4
|
0.2
|
1.0
|
|
HB2
|
A:ASP231
|
3.5
|
0.5
|
1.0
|
|
CB
|
A:CYS209
|
3.5
|
0.9
|
1.0
|
|
HB2
|
A:CYS209
|
3.6
|
0.2
|
1.0
|
|
H
|
A:HIS212
|
3.7
|
0.8
|
1.0
|
|
HB3
|
A:CYS209
|
3.7
|
0.2
|
1.0
|
|
HG22
|
A:VAL211
|
3.7
|
0.8
|
1.0
|
|
CB
|
A:HIS212
|
3.7
|
0.8
|
1.0
|
|
CB
|
A:CYS232
|
3.8
|
1.0
|
1.0
|
|
N
|
A:CYS232
|
3.9
|
0.5
|
1.0
|
|
NE2
|
A:HIS212
|
3.9
|
0.7
|
1.0
|
|
CG2
|
A:VAL211
|
3.9
|
0.5
|
1.0
|
|
CB
|
A:CYS229
|
4.0
|
0.8
|
1.0
|
|
HB2
|
A:CYS232
|
4.0
|
0.2
|
1.0
|
|
CD2
|
A:HIS212
|
4.2
|
0.1
|
1.0
|
|
HB2
|
A:CYS229
|
4.2
|
0.1
|
1.0
|
|
HG21
|
A:VAL211
|
4.2
|
0.8
|
1.0
|
|
HB3
|
A:ASP231
|
4.3
|
0.5
|
1.0
|
|
HB3
|
A:CYS229
|
4.3
|
0.1
|
1.0
|
|
CB
|
A:ASP231
|
4.3
|
0.0
|
1.0
|
|
CA
|
A:CYS232
|
4.3
|
0.8
|
1.0
|
|
N
|
A:HIS212
|
4.4
|
0.5
|
1.0
|
|
HA
|
A:CYS232
|
4.4
|
0.7
|
1.0
|
|
HB3
|
A:HIS212
|
4.4
|
0.9
|
1.0
|
|
H
|
A:VAL211
|
4.5
|
0.7
|
1.0
|
|
HB3
|
A:CYS232
|
4.5
|
0.2
|
1.0
|
|
H
|
A:ASN210
|
4.6
|
0.7
|
1.0
|
|
C
|
A:ASP231
|
4.6
|
0.9
|
1.0
|
|
H
|
A:CYS229
|
4.7
|
0.2
|
1.0
|
|
HE2
|
A:HIS212
|
4.7
|
0.1
|
1.0
|
|
OE1
|
A:GLU215
|
4.7
|
1.0
|
1.0
|
|
CA
|
A:HIS212
|
4.7
|
0.4
|
1.0
|
|
H
|
A:ASP231
|
4.9
|
0.5
|
1.0
|
|
CA
|
A:CYS209
|
4.9
|
0.9
|
1.0
|
|
CA
|
A:ASP231
|
5.0
|
0.5
|
1.0
|
|
Zinc binding site 4 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 4 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn503
b:0.6
occ:1.00
|
HB3
|
A:SER223
|
1.5
|
0.3
|
1.0
|
|
ND1
|
A:HIS240
|
2.1
|
0.6
|
1.0
|
|
ND1
|
A:HIS237
|
2.1
|
0.7
|
1.0
|
|
CB
|
A:SER223
|
2.3
|
0.0
|
1.0
|
|
HE1
|
A:HIS240
|
2.3
|
0.0
|
1.0
|
|
SG
|
A:CYS221
|
2.3
|
0.7
|
1.0
|
|
CE1
|
A:HIS240
|
2.5
|
0.8
|
1.0
|
|
SG
|
A:CYS224
|
2.5
|
0.9
|
0.4
|
|
OG
|
A:SER223
|
2.6
|
0.0
|
1.0
|
|
H
|
A:CYS224
|
2.7
|
0.1
|
1.0
|
|
CE1
|
A:HIS237
|
2.8
|
0.5
|
1.0
|
|
HB2
|
A:SER223
|
2.8
|
0.3
|
1.0
|
|
HE1
|
A:HIS237
|
2.8
|
0.9
|
1.0
|
|
N
|
A:CYS224
|
3.2
|
0.9
|
1.0
|
|
CG
|
A:HIS237
|
3.3
|
0.8
|
1.0
|
|
CG
|
A:HIS240
|
3.4
|
0.1
|
1.0
|
|
HB3
|
A:HIS237
|
3.4
|
0.8
|
1.0
|
|
HG
|
A:SER223
|
3.4
|
0.1
|
1.0
|
|
CA
|
A:SER223
|
3.5
|
0.6
|
1.0
|
|
C
|
A:SER223
|
3.7
|
0.2
|
1.0
|
|
CB
|
A:CYS224
|
3.7
|
0.0
|
1.0
|
|
H
|
A:SER223
|
3.8
|
0.2
|
1.0
|
|
NE2
|
A:HIS240
|
3.8
|
0.9
|
1.0
|
|
HB2
|
A:CYS224
|
3.8
|
0.3
|
1.0
|
|
CB
|
A:HIS237
|
3.8
|
0.7
|
1.0
|
|
CB
|
A:CYS221
|
3.9
|
0.7
|
1.0
|
|
NE2
|
A:HIS237
|
3.9
|
0.9
|
1.0
|
|
HB3
|
A:HIS240
|
4.0
|
0.1
|
1.0
|
|
HB3
|
A:CYS221
|
4.0
|
0.9
|
1.0
|
|
N
|
A:SER223
|
4.1
|
0.9
|
1.0
|
|
CA
|
A:CYS224
|
4.1
|
0.3
|
1.0
|
|
HA
|
A:HIS237
|
4.1
|
0.8
|
1.0
|
|
CD2
|
A:HIS237
|
4.2
|
0.2
|
1.0
|
|
CB
|
A:HIS240
|
4.2
|
0.6
|
1.0
|
|
CD2
|
A:HIS240
|
4.2
|
0.3
|
1.0
|
|
HB2
|
A:CYS221
|
4.2
|
0.9
|
1.0
|
|
HA
|
A:SER223
|
4.2
|
0.4
|
1.0
|
|
HB2
|
A:HIS240
|
4.3
|
0.1
|
1.0
|
|
HE2
|
A:HIS240
|
4.4
|
0.7
|
1.0
|
|
HA
|
A:CYS224
|
4.6
|
0.7
|
1.0
|
|
CA
|
A:HIS237
|
4.6
|
0.5
|
1.0
|
|
HB3
|
A:CYS224
|
4.6
|
0.3
|
1.0
|
|
HE2
|
A:HIS237
|
4.6
|
0.0
|
1.0
|
|
HB2
|
A:HIS237
|
4.7
|
0.8
|
1.0
|
|
O
|
A:SER223
|
4.7
|
0.6
|
1.0
|
|
Zinc binding site 5 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 5 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn501
b:0.5
occ:1.00
|
HD1
|
B:HIS237
|
2.0
|
0.3
|
1.0
|
|
ND1
|
B:HIS237
|
2.0
|
0.4
|
1.0
|
|
ND1
|
B:HIS240
|
2.0
|
0.5
|
1.0
|
|
SG
|
B:CYS224
|
2.3
|
76.1
|
0.5
|
|
SG
|
B:CYS221
|
2.4
|
73.5
|
1.0
|
|
CG
|
B:HIS237
|
2.4
|
0.1
|
1.0
|
|
HB3
|
B:HIS237
|
2.5
|
0.4
|
1.0
|
|
HE1
|
B:HIS240
|
2.6
|
0.5
|
1.0
|
|
CE1
|
B:HIS240
|
2.6
|
0.2
|
1.0
|
|
CE1
|
B:HIS237
|
2.7
|
0.5
|
1.0
|
|
CB
|
B:HIS237
|
2.9
|
0.5
|
1.0
|
|
CD2
|
B:HIS237
|
3.2
|
0.4
|
1.0
|
|
HB2
|
B:CYS224
|
3.2
|
85.2
|
1.0
|
|
HE1
|
B:HIS237
|
3.2
|
0.7
|
1.0
|
|
CG
|
B:HIS240
|
3.2
|
0.3
|
1.0
|
|
NE2
|
B:HIS237
|
3.3
|
0.0
|
1.0
|
|
H
|
B:CYS224
|
3.3
|
89.5
|
1.0
|
|
CB
|
B:CYS224
|
3.4
|
71.0
|
1.0
|
|
HB2
|
B:SER223
|
3.6
|
0.2
|
1.0
|
|
CB
|
B:CYS221
|
3.6
|
89.4
|
1.0
|
|
HB3
|
B:CYS221
|
3.6
|
0.3
|
1.0
|
|
HB2
|
B:CYS221
|
3.6
|
0.3
|
1.0
|
|
HA
|
B:HIS237
|
3.6
|
0.2
|
1.0
|
|
HB2
|
B:HIS237
|
3.7
|
0.4
|
1.0
|
|
HB2
|
B:HIS240
|
3.8
|
0.7
|
1.0
|
|
HB3
|
B:HIS240
|
3.8
|
0.7
|
1.0
|
|
NE2
|
B:HIS240
|
3.8
|
0.1
|
1.0
|
|
HD2
|
B:HIS237
|
3.9
|
0.1
|
1.0
|
|
CB
|
B:HIS240
|
3.9
|
90.5
|
1.0
|
|
CA
|
B:HIS237
|
3.9
|
0.6
|
1.0
|
|
N
|
B:CYS224
|
4.0
|
74.6
|
1.0
|
|
HB3
|
B:CYS224
|
4.1
|
85.2
|
1.0
|
|
CD2
|
B:HIS240
|
4.1
|
0.1
|
1.0
|
|
CA
|
B:CYS224
|
4.3
|
0.8
|
1.0
|
|
CB
|
B:SER223
|
4.5
|
0.8
|
1.0
|
|
HE2
|
B:HIS240
|
4.5
|
0.4
|
1.0
|
|
HB3
|
B:SER223
|
4.6
|
0.2
|
1.0
|
|
N
|
B:HIS237
|
4.7
|
0.6
|
1.0
|
|
H
|
B:HIS237
|
4.7
|
0.0
|
1.0
|
|
HG3
|
B:GLN233
|
4.8
|
0.5
|
1.0
|
|
HA
|
B:CYS224
|
4.9
|
0.2
|
1.0
|
|
C
|
B:SER223
|
5.0
|
0.2
|
1.0
|
|
CA
|
B:CYS221
|
5.0
|
75.6
|
1.0
|
|
Zinc binding site 6 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 6 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn502
b:0.4
occ:1.00
|
HG23
|
B:VAL211
|
1.6
|
0.1
|
1.0
|
|
ND1
|
B:HIS212
|
2.1
|
0.3
|
1.0
|
|
CG2
|
B:VAL211
|
2.3
|
0.0
|
1.0
|
|
H
|
B:HIS212
|
2.3
|
0.5
|
1.0
|
|
SG
|
B:CYS232
|
2.3
|
66.2
|
1.0
|
|
HG22
|
B:VAL211
|
2.4
|
0.1
|
1.0
|
|
HG21
|
B:VAL211
|
2.5
|
0.1
|
1.0
|
|
SG
|
B:CYS209
|
2.6
|
0.1
|
0.4
|
|
HB2
|
B:HIS212
|
2.6
|
1.0
|
1.0
|
|
CG
|
B:HIS212
|
2.8
|
0.9
|
1.0
|
|
N
|
B:HIS212
|
2.8
|
0.5
|
1.0
|
|
SG
|
B:CYS229
|
2.8
|
63.1
|
1.0
|
|
CB
|
B:HIS212
|
3.0
|
0.6
|
1.0
|
|
CE1
|
B:HIS212
|
3.1
|
0.6
|
1.0
|
|
H
|
B:VAL211
|
3.3
|
1.0
|
1.0
|
|
HE1
|
B:HIS212
|
3.5
|
0.2
|
1.0
|
|
CA
|
B:HIS212
|
3.5
|
0.1
|
1.0
|
|
CB
|
B:VAL211
|
3.5
|
0.9
|
1.0
|
|
C
|
B:VAL211
|
3.7
|
0.5
|
1.0
|
|
HB3
|
B:CYS209
|
3.8
|
0.8
|
1.0
|
|
N
|
B:VAL211
|
3.8
|
0.6
|
1.0
|
|
CA
|
B:VAL211
|
3.9
|
1.0
|
1.0
|
|
CD2
|
B:HIS212
|
3.9
|
0.1
|
1.0
|
|
CB
|
B:CYS209
|
3.9
|
0.4
|
1.0
|
|
HB
|
B:VAL211
|
3.9
|
0.6
|
1.0
|
|
HB3
|
B:HIS212
|
3.9
|
1.0
|
1.0
|
|
NE2
|
B:HIS212
|
4.0
|
0.6
|
1.0
|
|
HA
|
B:HIS212
|
4.1
|
0.2
|
1.0
|
|
CB
|
B:CYS232
|
4.1
|
87.3
|
1.0
|
|
HB2
|
B:CYS209
|
4.4
|
0.8
|
1.0
|
|
H
|
B:ASN210
|
4.4
|
0.7
|
1.0
|
|
HB3
|
B:CYS232
|
4.5
|
0.8
|
1.0
|
|
CB
|
B:CYS229
|
4.5
|
0.1
|
1.0
|
|
HB2
|
B:CYS232
|
4.5
|
0.8
|
1.0
|
|
HG13
|
B:VAL211
|
4.5
|
0.0
|
1.0
|
|
CG1
|
B:VAL211
|
4.6
|
0.8
|
1.0
|
|
HB3
|
B:CYS229
|
4.6
|
0.2
|
1.0
|
|
C
|
B:HIS212
|
4.7
|
0.5
|
1.0
|
|
HD2
|
B:HIS212
|
4.7
|
0.0
|
1.0
|
|
O
|
B:VAL211
|
4.7
|
0.8
|
1.0
|
|
HA
|
B:CYS232
|
4.7
|
0.1
|
1.0
|
|
H
|
B:CYS232
|
4.7
|
0.1
|
1.0
|
|
N
|
B:ASN210
|
4.7
|
0.9
|
1.0
|
|
OE1
|
B:GLU215
|
4.7
|
0.2
|
1.0
|
|
HG11
|
B:VAL211
|
4.8
|
0.0
|
1.0
|
|
HB2
|
B:CYS229
|
4.8
|
0.2
|
1.0
|
|
HE2
|
B:HIS212
|
4.8
|
0.7
|
1.0
|
|
HA
|
B:VAL211
|
4.8
|
0.2
|
1.0
|
|
O
|
B:HIS212
|
4.8
|
0.1
|
1.0
|
|
CA
|
B:CYS232
|
4.9
|
0.4
|
1.0
|
|
C
|
B:ASN210
|
4.9
|
0.2
|
1.0
|
|
HB2
|
B:ASP231
|
4.9
|
91.9
|
1.0
|
|
N
|
B:CYS232
|
5.0
|
0.3
|
1.0
|
|
Zinc binding site 7 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 7 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn503
b:70.6
occ:1.00
|
SG
|
B:CYS68
|
2.3
|
0.2
|
0.7
|
|
SG
|
B:CYS91
|
2.3
|
93.4
|
1.0
|
|
SG
|
B:CYS88
|
2.4
|
0.4
|
1.0
|
|
SG
|
B:CYS65
|
2.4
|
93.5
|
1.0
|
|
H
|
B:CYS68
|
2.6
|
0.1
|
1.0
|
|
HB3
|
B:CYS68
|
3.3
|
0.8
|
1.0
|
|
HB
|
B:VAL67
|
3.3
|
0.1
|
1.0
|
|
CB
|
B:CYS68
|
3.3
|
0.6
|
1.0
|
|
HB2
|
B:CYS65
|
3.4
|
99.9
|
1.0
|
|
HB2
|
B:CYS88
|
3.4
|
0.7
|
1.0
|
|
HB2
|
B:CYS91
|
3.4
|
0.1
|
1.0
|
|
N
|
B:CYS68
|
3.4
|
0.3
|
1.0
|
|
CB
|
B:CYS91
|
3.5
|
88.4
|
1.0
|
|
CB
|
B:CYS65
|
3.5
|
83.2
|
1.0
|
|
H
|
B:CYS88
|
3.5
|
94.2
|
1.0
|
|
CB
|
B:CYS88
|
3.5
|
0.5
|
1.0
|
|
HB3
|
B:CYS91
|
3.7
|
0.1
|
1.0
|
|
HB3
|
B:CYS65
|
3.7
|
99.9
|
1.0
|
|
CA
|
B:CYS68
|
3.9
|
0.3
|
1.0
|
|
H
|
B:VAL67
|
4.1
|
0.8
|
1.0
|
|
HB2
|
B:CYS68
|
4.2
|
0.8
|
1.0
|
|
N
|
B:CYS88
|
4.2
|
78.5
|
1.0
|
|
HB3
|
B:CYS88
|
4.2
|
0.7
|
1.0
|
|
H
|
B:GLU70
|
4.2
|
0.4
|
1.0
|
|
CB
|
B:VAL67
|
4.3
|
0.8
|
1.0
|
|
H
|
B:ARG69
|
4.3
|
0.2
|
1.0
|
|
HB2
|
B:GLU70
|
4.3
|
0.1
|
1.0
|
|
C
|
B:CYS68
|
4.5
|
0.7
|
1.0
|
|
CA
|
B:CYS88
|
4.5
|
80.1
|
1.0
|
|
C
|
B:VAL67
|
4.5
|
95.6
|
1.0
|
|
N
|
B:ARG69
|
4.6
|
97.6
|
1.0
|
|
HG23
|
B:VAL67
|
4.7
|
0.9
|
1.0
|
|
HA
|
B:CYS68
|
4.7
|
0.0
|
1.0
|
|
HD21
|
B:LEU72
|
4.8
|
0.7
|
1.0
|
|
CA
|
B:VAL67
|
4.8
|
89.7
|
1.0
|
|
N
|
B:VAL67
|
4.8
|
86.4
|
1.0
|
|
H
|
B:CYS91
|
4.8
|
0.7
|
1.0
|
|
HA
|
B:ALA87
|
4.8
|
88.8
|
1.0
|
|
CA
|
B:CYS91
|
4.8
|
91.4
|
1.0
|
|
CA
|
B:CYS65
|
4.9
|
82.0
|
1.0
|
|
HG12
|
B:VAL67
|
5.0
|
0.5
|
1.0
|
|
CG2
|
B:VAL67
|
5.0
|
84.8
|
1.0
|
|
Zinc binding site 8 out
of 8 in 6qaj
Go back to
Zinc Binding Sites List in 6qaj
Zinc binding site 8 out
of 8 in the Structure of the Tripartite Motif of KAP1/TRIM28
 Mono view
 Stereo pair view
|
|
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Structure of the Tripartite Motif of KAP1/TRIM28 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn504
b:0.2
occ:1.00
|
ND1
|
B:HIS85
|
2.0
|
67.4
|
1.0
|
|
SG
|
B:CYS83
|
2.2
|
0.2
|
1.0
|
|
SG
|
B:CYS120
|
2.2
|
73.0
|
1.0
|
|
SG
|
B:CYS117
|
2.2
|
64.7
|
1.0
|
|
HB2
|
B:CYS83
|
2.6
|
75.4
|
1.0
|
|
CE1
|
B:HIS85
|
2.8
|
66.7
|
1.0
|
|
HE1
|
B:HIS85
|
2.8
|
80.1
|
1.0
|
|
CB
|
B:CYS83
|
2.9
|
62.8
|
1.0
|
|
HG23
|
B:VAL119
|
3.1
|
0.8
|
1.0
|
|
CG
|
B:HIS85
|
3.1
|
66.3
|
1.0
|
|
HB2
|
B:HIS85
|
3.2
|
85.6
|
1.0
|
|
HB3
|
B:CYS117
|
3.2
|
80.8
|
1.0
|
|
CB
|
B:CYS117
|
3.2
|
67.3
|
1.0
|
|
HB3
|
B:CYS83
|
3.3
|
75.4
|
1.0
|
|
H
|
B:CYS120
|
3.3
|
0.7
|
1.0
|
|
HB2
|
B:CYS117
|
3.3
|
80.8
|
1.0
|
|
HB3
|
B:CYS120
|
3.5
|
81.8
|
1.0
|
|
CB
|
B:CYS120
|
3.5
|
68.1
|
1.0
|
|
CB
|
B:HIS85
|
3.7
|
71.3
|
1.0
|
|
HG22
|
B:VAL119
|
3.7
|
0.8
|
1.0
|
|
CG2
|
B:VAL119
|
3.8
|
96.5
|
1.0
|
|
NE2
|
B:HIS85
|
3.9
|
67.9
|
1.0
|
|
HG21
|
B:VAL119
|
4.0
|
0.8
|
1.0
|
|
N
|
B:CYS120
|
4.0
|
89.7
|
1.0
|
|
CD2
|
B:HIS85
|
4.1
|
82.6
|
1.0
|
|
H
|
B:HIS85
|
4.1
|
99.2
|
1.0
|
|
HB3
|
B:HIS85
|
4.2
|
85.6
|
1.0
|
|
HB2
|
B:CYS120
|
4.2
|
81.8
|
1.0
|
|
HB2
|
B:GLN122
|
4.3
|
79.3
|
1.0
|
|
CA
|
B:CYS83
|
4.3
|
60.7
|
1.0
|
|
CA
|
B:CYS120
|
4.3
|
69.9
|
1.0
|
|
H
|
B:GLN122
|
4.4
|
76.7
|
1.0
|
|
H
|
B:VAL119
|
4.4
|
86.7
|
1.0
|
|
O
|
B:CYS83
|
4.5
|
74.3
|
1.0
|
|
C
|
B:CYS83
|
4.6
|
62.0
|
1.0
|
|
HB2
|
B:LEU81
|
4.6
|
71.5
|
1.0
|
|
HE2
|
B:HIS85
|
4.6
|
81.5
|
1.0
|
|
H
|
B:CYS83
|
4.7
|
0.5
|
1.0
|
|
H
|
B:LYS121
|
4.7
|
0.6
|
1.0
|
|
CA
|
B:CYS117
|
4.7
|
66.3
|
1.0
|
|
N
|
B:HIS85
|
4.7
|
82.6
|
1.0
|
|
CA
|
B:HIS85
|
4.8
|
65.6
|
1.0
|
|
C
|
B:CYS120
|
4.9
|
69.1
|
1.0
|
|
HD13
|
B:LEU81
|
4.9
|
76.1
|
1.0
|
|
HA
|
B:CYS83
|
4.9
|
72.8
|
1.0
|
|
HA
|
B:CYS117
|
5.0
|
79.7
|
1.0
|
|
N
|
B:LYS121
|
5.0
|
91.3
|
1.0
|
|
Reference:
G.A.Stoll,
S.I.Oda,
Z.S.Chong,
M.Yu,
S.H.Mclaughlin,
Y.Modis.
Structure of KAP1 Tripartite Motif Identifies Molecular Interfaces Required For Retroelement Silencing. Proc.Natl.Acad.Sci.Usa V. 116 15042 2019.
ISSN: ESSN 1091-6490
PubMed: 31289231
DOI: 10.1073/PNAS.1901318116
Page generated: Tue Oct 29 05:33:09 2024
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