Zinc in PDB 6pzq: Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna

The structure of Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna, PDB code: 6pzq was solved by Y.Gao, D.Cao, B.Liang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	63.52 / 2.70
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	94.750, 94.750, 199.630, 90.00, 90.00, 90.00
R / Rfree (%)	22.5 / 28.8

The binding sites of Zinc atom in the Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna (pdb code 6pzq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna, PDB code: 6pzq:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:79.4 occ:1.00 NE2 A:HIS25 2.1 77.5 1.0 SG A:CYS7 2.1 65.5 1.0 SG A:CYS15 2.3 0.3 1.0 HB2 A:CYS15 2.6 98.7 1.0 SG A:CYS21 2.6 85.8 1.0 CB A:CYS15 2.9 82.3 1.0 CE1 A:HIS25 3.0 85.1 1.0 HB3 A:CYS21 3.1 92.5 1.0 CD2 A:HIS25 3.1 74.9 1.0 HE1 A:HIS25 3.1 0.1 1.0 O A:HOH302 3.2 66.3 1.0 HB2 A:CYS7 3.2 82.5 1.0 HB3 A:CYS15 3.2 98.7 1.0 CB A:CYS21 3.3 77.1 1.0 CB A:CYS7 3.3 68.8 1.0 HD2 A:HIS25 3.3 89.9 1.0 HB2 A:CYS21 3.4 92.5 1.0 HB2 A:PHE9 3.6 80.6 1.0 HB3 A:CYS7 3.7 82.5 1.0 H61 I:A6 3.7 84.0 1.0 HB2 A:ASN17 4.0 0.5 1.0 ND1 A:HIS25 4.1 82.7 1.0 CG A:HIS25 4.2 78.7 1.0 HB2 A:PHE23 4.3 93.5 1.0 HD2 A:PHE9 4.3 80.2 1.0 CA A:CYS15 4.3 74.2 1.0 H A:GLU10 4.3 85.8 1.0 HB2 A:GLU10 4.3 78.7 1.0 HA A:CYS15 4.4 89.1 1.0 N6 I:A6 4.4 70.0 1.0 H62 I:A6 4.4 84.0 1.0 HA A:CYS7 4.5 78.8 1.0 CB A:PHE9 4.6 67.2 1.0 CA A:CYS7 4.6 65.6 1.0 H A:ASN17 4.7 90.9 1.0 H A:PHE9 4.7 80.5 1.0 CA A:CYS21 4.8 93.0 1.0 H A:PHE23 4.8 0.8 1.0 HD1 A:HIS25 4.8 99.2 1.0 HB3 A:PHE9 4.8 80.6 1.0 CB A:ASN17 5.0 87.9 1.0 N A:GLU10 5.0 71.5 1.0 CD2 A:PHE9 5.0 66.9 1.0

Zinc binding site 2 out of 4 in the Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:0.3 occ:1.00 HE2 B:HIS25 1.2 0.8 1.0 SG B:CYS15 1.6 61.4 1.0 SG B:CYS7 1.9 62.4 1.0 SG B:CYS21 2.0 79.8 1.0 NE2 B:HIS25 2.1 92.4 1.0 CD2 B:HIS25 2.9 80.0 1.0 HD2 B:HIS25 3.1 96.0 1.0 HB2 B:CYS7 3.1 73.7 1.0 HB2 B:CYS15 3.1 78.4 1.0 CE1 B:HIS25 3.1 92.4 1.0 CB B:CYS15 3.1 65.3 1.0 HB3 B:CYS21 3.1 90.6 1.0 CB B:CYS7 3.2 61.4 1.0 CB B:CYS21 3.2 75.5 1.0 HE1 B:HIS25 3.3 0.9 1.0 HB3 B:CYS15 3.4 78.4 1.0 HB3 B:CYS7 3.5 73.7 1.0 HB2 B:CYS21 3.5 90.6 1.0 HB2 B:PHE23 3.9 98.7 1.0 HD2 B:PHE9 4.0 91.7 1.0 CG B:HIS25 4.1 69.0 1.0 HB2 B:PHE9 4.1 78.5 1.0 ND1 B:HIS25 4.2 74.5 1.0 HB2 B:ASN17 4.2 85.7 1.0 HD22 B:ASN17 4.2 94.9 1.0 HD2 B:PHE23 4.4 92.9 1.0 H B:PHE23 4.4 99.8 1.0 HB2 B:GLU10 4.5 76.9 1.0 CA B:CYS15 4.5 75.5 1.0 CA B:CYS21 4.5 85.2 1.0 CA B:CYS7 4.6 58.2 1.0 HA B:CYS15 4.6 90.6 1.0 H B:GLU10 4.6 85.6 1.0 HA B:CYS7 4.7 69.9 1.0 O B:CYS21 4.8 86.7 1.0 C B:CYS21 4.8 86.4 1.0 CD2 B:PHE9 4.9 76.4 1.0 O B:PHE23 4.9 76.8 1.0 CB B:PHE23 4.9 82.2 1.0 H B:PHE9 4.9 76.2 1.0 HA B:CYS21 4.9 0.3 1.0 ND2 B:ASN17 5.0 79.1 1.0 H B:ASN17 5.0 67.2 1.0

Zinc binding site 3 out of 4 in the Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:85.4 occ:1.00 HE1 C:HIS25 1.7 0.5 1.0 SG C:CYS15 2.2 79.0 1.0 CE1 C:HIS25 2.3 87.0 1.0 SG C:CYS7 2.5 70.2 1.0 SG C:CYS21 2.5 91.9 1.0 HE2 C:HIS25 2.8 0.5 1.0 HB2 C:CYS15 2.8 95.2 1.0 NE2 C:HIS25 2.8 86.3 1.0 HB2 C:CYS7 3.0 93.1 1.0 CB C:CYS15 3.1 79.3 1.0 HB3 C:CYS21 3.1 0.3 1.0 CB C:CYS7 3.2 77.5 1.0 CB C:CYS21 3.2 97.8 1.0 HB2 C:CYS21 3.4 0.3 1.0 ND1 C:HIS25 3.4 88.4 1.0 HB3 C:CYS7 3.5 93.1 1.0 HB3 C:CYS15 3.5 95.2 1.0 HD2 C:PHE9 3.9 95.7 1.0 HB2 C:PHE23 4.1 0.8 1.0 CD2 C:HIS25 4.1 88.4 1.0 HB2 C:ASN17 4.1 97.5 1.0 HB2 C:PHE9 4.1 87.7 1.0 HA C:CYS15 4.3 86.2 1.0 CA C:CYS15 4.3 71.8 1.0 CG C:HIS25 4.4 71.9 1.0 HB2 C:GLU10 4.4 87.9 1.0 CA C:CYS7 4.6 82.2 1.0 HD22 C:ASN17 4.6 0.8 1.0 H C:GLU10 4.6 85.5 1.0 H C:PHE23 4.7 0.7 1.0 HA C:CYS7 4.7 98.6 1.0 H C:PHE9 4.7 83.1 1.0 CD2 C:PHE9 4.7 79.7 1.0 CA C:CYS21 4.7 0.3 1.0 HD1 C:PHE23 4.8 0.3 1.0 H C:ASN17 4.8 82.1 1.0 HD2 C:HIS25 4.8 0.1 1.0 O C:PHE23 4.9 77.8 1.0

Zinc binding site 4 out of 4 in the Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn201 b:86.9 occ:1.00 NE2 D:HIS25 2.1 84.4 1.0 SG D:CYS7 2.2 77.6 1.0 SG D:CYS15 2.2 1.0 1.0 SG D:CYS21 2.4 87.7 1.0 HB2 D:CYS15 2.9 0.0 1.0 CE1 D:HIS25 3.0 88.3 1.0 CB D:CYS15 3.0 90.8 1.0 HB3 D:CYS21 3.1 0.5 1.0 HE1 D:HIS25 3.1 0.0 1.0 CD2 D:HIS25 3.1 86.5 1.0 HB2 D:CYS7 3.2 91.2 1.0 CB D:CYS21 3.2 90.5 1.0 HB3 D:CYS15 3.3 0.0 1.0 CB D:CYS7 3.3 76.0 1.0 HB2 D:CYS21 3.3 0.5 1.0 HD2 D:HIS25 3.4 0.8 1.0 HB3 D:CYS7 3.6 91.2 1.0 HB2 D:PHE9 3.8 0.6 1.0 HB2 D:ASN17 3.8 0.8 1.0 HD22 D:ASN17 3.9 0.9 1.0 ND1 D:HIS25 4.1 90.0 1.0 CG D:HIS25 4.2 84.7 1.0 HB2 D:PHE23 4.2 0.9 1.0 HD1 D:PHE9 4.4 0.1 1.0 CA D:CYS15 4.4 84.7 1.0 ND2 D:ASN17 4.5 98.2 1.0 HB2 D:GLU10 4.5 90.8 1.0 H D:ASN17 4.5 0.5 1.0 HA D:CYS15 4.5 0.6 1.0 CA D:CYS7 4.6 80.7 1.0 HA D:CYS7 4.6 96.8 1.0 H D:GLU10 4.6 0.6 1.0 CA D:CYS21 4.7 98.8 1.0 H D:PHE9 4.7 0.8 1.0 CB D:PHE9 4.8 93.9 1.0 CB D:ASN17 4.8 88.2 1.0 H D:PHE23 4.9 0.6 1.0 HD1 D:HIS25 4.9 1.0 1.0 HD1 D:PHE23 4.9 0.5 1.0 CD1 D:PHE9 4.9 98.4 1.0 HD21 D:ASN17 5.0 0.9 1.0 CG D:ASN17 5.0 91.6 1.0

Y.Gao, D.Cao, S.Pawnikar, K.P.John, H.M.Ahn, S.Hill, J.M.Ha, P.Parikh, C.Ogilvie, A.Swain, A.Yang, A.Bell, A.Salazar, Y.Miao, B.Liang. Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with A Short Positive-Sense Gene-End Rna. Structure V. 28 979 2020.
ISSN: ISSN 0969-2126
PubMed: 32697936
DOI: 10.1016/J.STR.2020.07.001