Zinc in PDB 6pww: Cryo-Em Structure of MLL1 in Complex with RBBP5 and WDR5 Bound to the Nucleosome

All present enzymatic activity of Cryo-Em Structure of MLL1 in Complex with RBBP5 and WDR5 Bound to the Nucleosome:
2.1.1.43;

The binding sites of Zinc atom in the Cryo-Em Structure of MLL1 in Complex with RBBP5 and WDR5 Bound to the Nucleosome (pdb code 6pww). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of MLL1 in Complex with RBBP5 and WDR5 Bound to the Nucleosome, PDB code: 6pww:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of MLL1 in Complex with RBBP5 and WDR5 Bound to the Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of MLL1 in Complex with RBBP5 and WDR5 Bound to the Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn4002 b:0.2 occ:1.01 N C:CYS3909 2.2 0.3 1.0 CB C:CYS3959 2.6 0.2 1.0 CB C:CYS3909 2.7 0.3 1.0 SG C:CYS3957 2.9 0.7 1.0 CA C:CYS3909 2.9 0.3 1.0 SG C:CYS3959 3.2 0.2 1.0 C C:SER3908 3.2 0.0 1.0 SG C:CYS3964 3.2 0.8 1.0 SG C:CYS3909 3.5 0.3 1.0 CA C:SER3908 3.5 0.0 1.0 N C:GLU3910 3.8 0.9 1.0 C C:CYS3909 3.8 0.3 1.0 CA C:CYS3959 4.0 0.2 1.0 CA C:CYS3964 4.3 0.8 1.0 N C:CYS3959 4.3 0.2 1.0 CB C:CYS3964 4.3 0.8 1.0 O C:SER3908 4.4 0.0 1.0 CB C:SER3908 4.4 0.0 1.0 CB C:CYS3957 4.5 0.7 1.0 N C:SER3908 4.6 0.0 1.0 CB C:ALA3961 4.6 0.4 1.0 O C:HIS3907 4.7 0.6 1.0 C C:CYS3959 4.8 0.2 1.0 CD2 C:HIS3907 4.9 0.6 1.0 O C:CYS3909 5.0 0.3 1.0

S.H.Park, A.Ayoub, Y.T.Lee, J.Xu, H.Kim, W.Zheng, B.Zhang, L.Sha, S.An, Y.Zhang, M.A.Cianfrocco, M.Su, Y.Dou, U.S.Cho. Cryo-Em Structure of the Human MLL1 Core Complex Bound to the Nucleosome. Nat Commun V. 10 5540 2019.
ISSN: ESSN 2041-1723
PubMed: 31804488
DOI: 10.1038/S41467-019-13550-2