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Zinc in PDB 6po8: Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)BenzonitrileEnzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)Benzonitrile
All present enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)Benzonitrile:
1.14.13.39; Protein crystallography data
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)Benzonitrile, PDB code: 6po8
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6po8:
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)Benzonitrile also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)Benzonitrile
(pdb code 6po8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)Benzonitrile, PDB code: 6po8: Zinc binding site 1 out of 1 in 6po8Go back to Zinc Binding Sites List in 6po8
Zinc binding site 1 out
of 1 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-((4-(2-Amino-4-Methylquinolin-7-Yl)-2- (Aminomethyl)Phenoxy)Methyl)Benzonitrile
Mono view Stereo pair view
Reference:
M.A.Cinelli,
C.T.Reidl,
H.Li,
G.Chreifi,
T.L.Poulos,
R.B.Silverman.
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target An Isoform-Specific Aspartate. J.Med.Chem. 2020.
Page generated: Wed Dec 16 12:31:14 2020
ISSN: ISSN 0022-2623 PubMed: 32302123 DOI: 10.1021/ACS.JMEDCHEM.9B01573 |
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