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Zinc in PDB 6owh: Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92
Enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92
All present enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92:
2.3.1.48;
2.3.1.48;
Protein crystallography data
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92, PDB code: 6owh
was solved by
S.J.Hermans,
M.C.Chung,
M.W.Parker,
T.Thomas,
J.B.Baell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 27.06 / 2.00 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 46.560, 57.290, 122.490, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.1 / 22.5 |
Other elements in 6owh:
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92 also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Iodine | (I) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92
(pdb code 6owh). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92, PDB code: 6owh:
In total only one binding site of Zinc was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92, PDB code: 6owh:
Zinc binding site 1 out of 1 in 6owh
Go back to
Zinc Binding Sites List in 6owh
Zinc binding site 1 out
of 1 in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 92 within 5.0Å range:
|
Reference:
D.L.Priebbenow,
D.J.Leaver,
N.Nguyen,
B.Cleary,
H.R.Lagiakos,
J.Sanchez,
L.Xue,
F.Huang,
Y.Sun,
P.Mujumdar,
R.Mudududdla,
S.Varghese,
S.Teguh,
S.A.Charman,
K.L.White,
D.M.Shackleford,
K.Katneni,
M.Cuellar,
J.M.Strasser,
J.L.Dahlin,
M.A.Walters,
I.P.Street,
B.J.Monahan,
K.E.Jarman,
H.Jousset Sabroux,
H.Falk,
M.C.Chung,
S.J.Hermans,
N.L.Downer,
M.W.Parker,
A.K.Voss,
T.Thomas,
J.B.Baell.
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, As Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem. 2020.
ISSN: ISSN 0022-2623
PubMed: 32118427
DOI: 10.1021/ACS.JMEDCHEM.9B02071
Page generated: Tue Oct 29 04:35:32 2024
ISSN: ISSN 0022-2623
PubMed: 32118427
DOI: 10.1021/ACS.JMEDCHEM.9B02071
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