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Zinc in PDB 6mae: Chain A. Udp-3-O-[3-Hydroxymyristoyl] N-Acetylglucosamine Deacetylase Pa-Lpxc Complexed with (R)-3-((S)-3-(4-(Cyclopropylethynyl)Phenyl)-2- Oxooxazolidin-5-Yl)-N-Hydroxy-2-Methyl-2-(Methylsulfonyl)PropenamideEnzymatic activity of Chain A. Udp-3-O-[3-Hydroxymyristoyl] N-Acetylglucosamine Deacetylase Pa-Lpxc Complexed with (R)-3-((S)-3-(4-(Cyclopropylethynyl)Phenyl)-2- Oxooxazolidin-5-Yl)-N-Hydroxy-2-Methyl-2-(Methylsulfonyl)Propenamide
All present enzymatic activity of Chain A. Udp-3-O-[3-Hydroxymyristoyl] N-Acetylglucosamine Deacetylase Pa-Lpxc Complexed with (R)-3-((S)-3-(4-(Cyclopropylethynyl)Phenyl)-2- Oxooxazolidin-5-Yl)-N-Hydroxy-2-Methyl-2-(Methylsulfonyl)Propenamide:
3.5.1.108; Protein crystallography data
The structure of Chain A. Udp-3-O-[3-Hydroxymyristoyl] N-Acetylglucosamine Deacetylase Pa-Lpxc Complexed with (R)-3-((S)-3-(4-(Cyclopropylethynyl)Phenyl)-2- Oxooxazolidin-5-Yl)-N-Hydroxy-2-Methyl-2-(Methylsulfonyl)Propenamide, PDB code: 6mae
was solved by
W.Shu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Chain A. Udp-3-O-[3-Hydroxymyristoyl] N-Acetylglucosamine Deacetylase Pa-Lpxc Complexed with (R)-3-((S)-3-(4-(Cyclopropylethynyl)Phenyl)-2- Oxooxazolidin-5-Yl)-N-Hydroxy-2-Methyl-2-(Methylsulfonyl)Propenamide
(pdb code 6mae). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Chain A. Udp-3-O-[3-Hydroxymyristoyl] N-Acetylglucosamine Deacetylase Pa-Lpxc Complexed with (R)-3-((S)-3-(4-(Cyclopropylethynyl)Phenyl)-2- Oxooxazolidin-5-Yl)-N-Hydroxy-2-Methyl-2-(Methylsulfonyl)Propenamide, PDB code: 6mae: Zinc binding site 1 out of 1 in 6maeGo back to Zinc Binding Sites List in 6mae
Zinc binding site 1 out
of 1 in the Chain A. Udp-3-O-[3-Hydroxymyristoyl] N-Acetylglucosamine Deacetylase Pa-Lpxc Complexed with (R)-3-((S)-3-(4-(Cyclopropylethynyl)Phenyl)-2- Oxooxazolidin-5-Yl)-N-Hydroxy-2-Methyl-2-(Methylsulfonyl)Propenamide
Mono view Stereo pair view
Reference:
P.S.Lee,
G.Lapointe,
A.M.Madera,
R.L.Simmons,
W.Xu,
A.Yifru,
M.Tjandra,
S.Karur,
A.Rico,
K.Thompson,
J.Bojkovic,
L.Xie,
K.Uehara,
A.Liu,
W.Shu,
C.Bellamacina,
D.Mckenney,
L.Morris,
G.R.Tonn,
C.Osborne,
B.M.Benton,
L.Mcdowell,
J.Fu,
Z.K.Sweeney.
Application of Virtual Screening to the Identification of New Lpxc Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. J. Med. Chem. V. 61 9360 2018.
Page generated: Wed Dec 16 12:19:03 2020
ISSN: ISSN 1520-4804 PubMed: 30226381 DOI: 10.1021/ACS.JMEDCHEM.8B01287 |
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