Zinc in PDB 6l0u: Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor

All present enzymatic activity of Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor:
4.4.1.5;

The structure of Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor, PDB code: 6l0u was solved by L.L.Jiang, L.Zhou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.16 / 1.95
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	41.785, 64.635, 65.794, 90.00, 101.58, 90.00
R / Rfree (%)	19.7 / 24.4

The structure of Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Zinc atom in the Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor (pdb code 6l0u). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor, PDB code: 6l0u:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:31.0 occ:1.00 O A:HOH311 2.0 30.7 1.0 OE2 B:GLU173 2.2 30.3 1.0 NE2 B:HIS127 2.2 22.0 1.0 OE1 A:GLU100 2.2 35.6 1.0 OE1 A:GLN34 2.2 27.8 1.0 O B:HOH318 2.7 36.5 1.0 CD A:GLU100 2.9 34.7 1.0 OE2 A:GLU100 2.9 40.8 1.0 CE1 B:HIS127 3.1 24.1 1.0 CD A:GLN34 3.2 28.8 1.0 CD2 B:HIS127 3.2 24.5 1.0 CD B:GLU173 3.3 33.9 1.0 NE2 A:GLN34 3.5 24.4 1.0 OE1 B:GLU173 3.8 44.0 1.0 ND1 B:HIS127 4.2 24.2 1.0 CG B:HIS127 4.3 23.4 1.0 CG A:GLU100 4.4 25.0 1.0 CB A:MET36 4.4 25.1 1.0 CG B:GLU173 4.5 24.8 1.0 CB B:GLU173 4.5 25.0 1.0 O A:HOH335 4.5 33.8 1.0 CG A:GLN34 4.6 28.3 1.0 CG A:MET36 4.6 26.3 1.0 CB A:GLU100 4.7 25.4 1.0 CZ B:PHE163 4.8 30.5 1.0 O B:HOH345 4.9 41.2 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:36.9 occ:1.00 OE1 A:GLU173 2.1 36.4 1.0 OE1 B:GLU100 2.1 37.3 1.0 O B:HOH317 2.2 36.5 1.0 OE1 B:GLN34 2.2 31.7 1.0 NE2 A:HIS127 2.2 28.3 1.0 O A:HOH328 2.7 43.5 1.0 CD B:GLU100 3.0 38.8 1.0 CE1 A:HIS127 3.2 31.3 1.0 CD A:GLU173 3.2 37.0 1.0 OE2 B:GLU100 3.2 47.8 1.0 CD2 A:HIS127 3.2 29.2 1.0 CD B:GLN34 3.2 33.4 1.0 OE2 A:GLU173 3.6 44.7 1.0 NE2 B:GLN34 3.6 34.7 1.0 ND1 A:HIS127 4.3 28.3 1.0 CG A:HIS127 4.4 25.4 1.0 CG B:GLU100 4.4 37.9 1.0 CB B:MET36 4.4 27.3 1.0 CG A:GLU173 4.4 36.8 1.0 CB A:GLU173 4.5 30.3 1.0 CG B:MET36 4.5 29.4 1.0 CG B:GLN34 4.6 30.0 1.0 CB B:GLU100 4.7 34.4 1.0 CZ A:PHE163 4.8 35.0 1.0 CE1 A:PHE163 5.0 31.9 1.0

L.L.Jiang, L.Zhou. Crystal Structure of Mouse Glyoxalase I Complexed with A Small Molecule Inhibitor To Be Published.