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Zinc in PDB 6kiz: Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE2

Enzymatic activity of Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE2

All present enzymatic activity of Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE2:
2.1.1.43;

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE2 (pdb code 6kiz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE2, PDB code: 6kiz:

Zinc binding site 1 out of 1 in 6kiz

Go back to Zinc Binding Sites List in 6kiz
Zinc binding site 1 out of 1 in the Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE2 within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn4002

b:1.0
occ:1.01
N K:CYS3959 2.3 1.0 1.0
SG K:CYS3959 2.5 1.0 1.0
C K:CYS3957 2.6 1.0 1.0
CB K:CYS3957 2.6 1.0 1.0
CB K:CYS3959 2.6 1.0 1.0
O K:CYS3957 2.6 1.0 1.0
CA K:CYS3959 3.0 1.0 1.0
SG K:CYS3957 3.0 1.0 1.0
CA K:CYS3957 3.0 1.0 1.0
N K:ASN3958 3.0 1.0 1.0
C K:ASN3958 3.3 1.0 1.0
CA K:ASN3958 3.6 1.0 1.0
N K:CYS3957 3.7 1.0 1.0
SG K:CYS3964 3.8 1.0 1.0
N K:GLY3960 4.0 1.0 1.0
C K:CYS3959 4.0 1.0 1.0
SG K:CYS3909 4.4 1.0 1.0
O K:ASN3958 4.4 1.0 1.0
O K:HIS3907 4.8 1.0 1.0
CB K:CYS3964 5.0 1.0 1.0

Reference:

H.Xue, T.Yao, M.Cao, G.Zhu, Y.Li, G.Yuan, Y.Chen, M.Lei, J.Huang. Structural Basis of Nucleosome Recognition and Modification By Mll Methyltransferases. Nature V. 573 445 2019.
ISSN: ESSN 1476-4687
PubMed: 31485071
DOI: 10.1038/S41586-019-1528-1
Page generated: Wed Dec 16 12:07:33 2020

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