Zinc in PDB 6i9h: Solution Structure of TRIM28 Ring Domain

All present enzymatic activity of Solution Structure of TRIM28 Ring Domain:
2.3.2.27;

The binding sites of Zinc atom in the Solution Structure of TRIM28 Ring Domain (pdb code 6i9h). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structure of TRIM28 Ring Domain, PDB code: 6i9h:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structure of TRIM28 Ring Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of TRIM28 Ring Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:0.0 occ:1.00 ND1 A:HIS85 2.1 0.0 1.0 SG A:CYS117 2.4 0.0 1.0 SG A:CYS120 2.4 0.0 1.0 SG A:CYS83 2.4 0.0 1.0 HB3 A:CYS117 2.5 0.0 1.0 HB A:VAL119 2.5 0.0 1.0 H A:CYS120 2.5 0.0 1.0 HB2 A:CYS83 2.7 0.0 1.0 CB A:CYS117 2.8 0.0 1.0 HE1 A:HIS85 2.8 0.0 1.0 CE1 A:HIS85 2.8 0.0 1.0 CB A:CYS83 3.0 0.0 1.0 HB2 A:CYS117 3.1 0.0 1.0 CG A:HIS85 3.3 0.0 1.0 HB3 A:CYS83 3.4 0.0 1.0 N A:CYS120 3.4 0.0 1.0 HB2 A:HIS85 3.5 0.0 1.0 CB A:VAL119 3.6 0.0 1.0 H A:VAL119 3.7 0.0 1.0 CB A:CYS120 3.7 0.0 1.0 HB3 A:CYS120 3.9 0.0 1.0 H A:LYS121 3.9 0.0 1.0 CB A:HIS85 3.9 0.0 1.0 NE2 A:HIS85 4.1 0.0 1.0 CA A:CYS120 4.2 0.0 1.0 HG23 A:VAL119 4.2 0.0 1.0 CA A:CYS117 4.2 0.0 1.0 HG21 A:VAL119 4.2 0.0 1.0 CG2 A:VAL119 4.3 0.0 1.0 CD2 A:HIS85 4.3 0.0 1.0 CA A:VAL119 4.3 0.0 1.0 C A:VAL119 4.3 0.0 1.0 N A:VAL119 4.3 0.0 1.0 CA A:CYS83 4.4 0.0 1.0 HG12 A:VAL119 4.4 0.0 1.0 HB3 A:HIS85 4.4 0.0 1.0 CG1 A:VAL119 4.5 0.0 1.0 HD22 A:LEU81 4.6 0.0 1.0 O A:CYS83 4.6 0.0 1.0 HB2 A:CYS120 4.6 0.0 1.0 C A:CYS117 4.6 0.0 1.0 HG13 A:VAL119 4.6 0.0 1.0 C A:CYS83 4.6 0.0 1.0 N A:LYS121 4.7 0.0 1.0 O A:CYS117 4.8 0.0 1.0 HA A:CYS117 4.8 0.0 1.0 H A:GLN122 4.8 0.0 1.0 H A:CYS83 4.8 0.0 1.0 HE2 A:HIS85 4.9 0.0 1.0 HB3 A:LEU81 4.9 0.0 1.0 H A:CYS117 4.9 0.0 1.0 C A:CYS120 5.0 0.0 1.0 HD23 A:LEU81 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Solution Structure of TRIM28 Ring Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of TRIM28 Ring Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:0.0 occ:1.00 SG A:CYS68 2.4 0.0 1.0 SG A:CYS91 2.4 0.0 1.0 SG A:CYS65 2.4 0.0 1.0 SG A:CYS88 2.4 0.0 1.0 H A:CYS68 2.7 0.0 1.0 HB3 A:CYS68 2.7 0.0 1.0 HB3 A:CYS65 2.7 0.0 1.0 HB A:VAL67 3.0 0.0 1.0 CB A:CYS65 3.0 0.0 1.0 CB A:CYS68 3.0 0.0 1.0 H A:CYS88 3.1 0.0 1.0 HB2 A:CYS91 3.1 0.0 1.0 HB2 A:CYS88 3.1 0.0 1.0 CB A:CYS91 3.2 0.0 1.0 N A:CYS68 3.3 0.0 1.0 HB3 A:CYS91 3.4 0.0 1.0 CB A:CYS88 3.4 0.0 1.0 HB2 A:CYS65 3.4 0.0 1.0 CA A:CYS68 3.8 0.0 1.0 N A:CYS88 3.9 0.0 1.0 HB2 A:CYS68 3.9 0.0 1.0 CB A:VAL67 4.0 0.0 1.0 HG11 A:VAL67 4.1 0.0 1.0 HB3 A:CYS88 4.2 0.0 1.0 H A:ARG69 4.2 0.0 1.0 C A:VAL67 4.2 0.0 1.0 H A:VAL67 4.3 0.0 1.0 CA A:CYS88 4.3 0.0 1.0 CA A:CYS65 4.3 0.0 1.0 HD3 A:ARG76 4.5 0.0 1.0 CA A:VAL67 4.5 0.0 1.0 CG1 A:VAL67 4.5 0.0 1.0 N A:VAL67 4.5 0.0 1.0 HA A:CYS68 4.6 0.0 1.0 C A:CYS65 4.6 0.0 1.0 H A:GLU70 4.6 0.0 1.0 HB2 A:ALA87 4.6 0.0 1.0 CA A:CYS91 4.6 0.0 1.0 H A:CYS91 4.6 0.0 1.0 O A:CYS65 4.6 0.0 1.0 C A:CYS68 4.7 0.0 1.0 N A:ARG69 4.8 0.0 1.0 HG12 A:VAL67 4.8 0.0 1.0 HA A:ALA87 4.8 0.0 1.0 H A:CYS65 4.9 0.0 1.0 HA A:CYS91 4.9 0.0 1.0 HA A:CYS65 5.0 0.0 1.0

R.V.Stevens, D.Esposito, K.Rittinger. Characterisation of Class VI Trim Ring Domains: Linking Ring Activity to C-Terminal Domain Identity. Life Sci Alliance V. 2 2019.
ISSN: ESSN 2575-1077
PubMed: 31028095
DOI: 10.26508/LSA.201900295