Zinc in PDB 6hc8: Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313- 339)

All present enzymatic activity of Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313- 339):
1.14.11.30;

The structure of Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313- 339), PDB code: 6hc8 was solved by T.M.Leissing, I.J.Clifton, B.G.Saward, X.Lu, R.J.Hopkinson, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	74.93 / 1.90
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.860, 86.860, 148.120, 90.00, 90.00, 90.00
R / Rfree (%)	17 / 18.9

The binding sites of Zinc atom in the Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313- 339) (pdb code 6hc8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313- 339), PDB code: 6hc8:

Zinc binding site 1 out of 1 in the Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313- 339)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313- 339) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:39.8 occ:1.00 OD2 A:ASP201 2.0 37.2 1.0 O2' A:OGA402 2.0 45.0 1.0 NE2 A:HIS279 2.1 44.0 1.0 NE2 A:HIS199 2.1 45.5 1.0 O2 A:OGA402 2.2 45.6 1.0 O A:HOH573 2.3 55.6 1.0 C2 A:OGA402 2.7 45.0 1.0 C1 A:OGA402 2.8 44.9 1.0 CG A:ASP201 3.0 40.8 1.0 CD2 A:HIS279 3.1 43.2 1.0 CE1 A:HIS199 3.1 42.7 1.0 CE1 A:HIS279 3.1 40.2 1.0 CD2 A:HIS199 3.1 39.7 1.0 OD1 A:ASP201 3.4 39.6 1.0 O A:HOH564 3.8 43.6 1.0 O1 A:OGA402 4.0 47.0 1.0 N1 A:OGA402 4.0 41.6 1.0 ND1 A:HIS199 4.2 40.3 1.0 ND1 A:HIS279 4.2 42.0 1.0 CG A:HIS279 4.2 46.7 1.0 CG A:HIS199 4.2 38.9 1.0 CZ2 A:TRP296 4.4 59.3 1.0 CB A:ASP201 4.4 36.0 1.0 O E:HOH402 4.6 57.9 1.0 ND2 E:ASN336 4.8 57.3 1.0 C4 A:OGA402 4.8 41.7 1.0 CG E:ASN336 4.9 58.1 1.0 CB E:ASN336 4.9 59.8 1.0

T.M.Leissing, I.J.Clifton, B.G.Saward, X.Lu, R.J.Hopkinson, C.J.Schofield. Factor Inhibiting Hif (Fih) in Complex with Zinc, Nog and TRPA1 (313-339) To Be Published.