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Zinc in PDB 6h6r: Fragment Derived Xiap InhibitorEnzymatic activity of Fragment Derived Xiap Inhibitor
All present enzymatic activity of Fragment Derived Xiap Inhibitor:
2.3.2.27; Protein crystallography data
The structure of Fragment Derived Xiap Inhibitor, PDB code: 6h6r
was solved by
P.A.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6h6r:
The structure of Fragment Derived Xiap Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Fragment Derived Xiap Inhibitor
(pdb code 6h6r). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Fragment Derived Xiap Inhibitor, PDB code: 6h6r: Zinc binding site 1 out of 1 in 6h6rGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Fragment Derived Xiap Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
C.N.Johnson,
J.S.Ahn,
I.M.Buck,
E.Chiarparin,
J.E.H.Day,
A.Hopkins,
S.Howard,
E.J.Lewis,
V.Martins,
A.Millemaggi,
J.M.Munck,
L.W.Page,
T.Peakman,
M.Reader,
S.J.Rich,
G.Saxty,
T.Smyth,
N.T.Thompson,
G.A.Ward,
P.A.Williams,
N.E.Wilsher,
G.Chessari.
A Fragment-Derived Clinical Candidate For Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)Methyl]-5-(Hydroxymethyl)-3, 3-Dimethyl-1 H,2 H,3 H-Pyrrolo[3,2- B]Pyridin-1-Yl)-2-[(2 R,5 R)-5-Methyl-2-([(3R)-3-Methylmorpholin-4-Yl]Methyl) Piperazin-1-Yl]Ethan-1-One (ASTX660). J. Med. Chem. V. 61 7314 2018.
Page generated: Wed Dec 16 11:55:55 2020
ISSN: ISSN 1520-4804 PubMed: 30091600 DOI: 10.1021/ACS.JMEDCHEM.8B00900 |
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