Zinc in PDB 6g90: Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)

The binding sites of Zinc atom in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) (pdb code 6g90). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 9 binding sites of Zinc where determined in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2), PDB code: 6g90:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Zinc binding site 1 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1000 b:89.8 occ:1.00 ND1 C:HIS30 2.0 59.5 1.0 NE2 C:HIS24 2.0 65.9 1.0 SG C:CYS6 2.1 63.8 1.0 SG C:CYS9 2.2 62.9 1.0 CE1 C:HIS30 2.8 59.5 1.0 CE1 C:HIS24 2.9 65.9 1.0 CD2 C:HIS24 3.0 65.9 1.0 CG C:HIS30 3.1 59.5 1.0 CB C:CYS9 3.3 62.9 1.0 CB C:CYS6 3.4 63.8 1.0 CB C:HIS30 3.6 59.5 1.0 NE2 C:HIS30 3.9 59.5 1.0 N C:CYS9 4.0 62.9 1.0 ND1 C:HIS24 4.0 65.9 1.0 CG C:HIS24 4.1 65.9 1.0 CD2 C:HIS30 4.1 59.5 1.0 CA C:HIS30 4.2 59.5 1.0 CA C:CYS9 4.2 62.9 1.0 CA C:CYS6 4.7 63.8 1.0 CB C:TYR8 4.8 53.2 1.0

Zinc binding site 2 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn1000 b:0.0 occ:1.00 CE1 H:HIS72 2.2 0.3 1.0 NE2 H:HIS72 2.2 0.3 1.0 SG H:CYS53 2.3 0.5 1.0 SG H:CYS45 2.5 0.7 1.0 CB H:CYS45 3.0 0.7 1.0 CB H:CYS68 3.1 0.0 1.0 ND1 H:HIS72 3.5 0.3 1.0 SG H:CYS68 3.5 0.0 1.0 CD2 H:HIS72 3.6 0.3 1.0 CB H:CYS53 4.0 0.5 1.0 CD H:PRO54 4.1 0.1 1.0 CG H:HIS72 4.2 0.3 1.0 CB H:TYR48 4.3 0.8 1.0 CA H:CYS45 4.5 0.7 1.0 CA H:CYS68 4.6 0.0 1.0 OG H:SER47 4.6 0.3 1.0 CA H:CYS53 4.7 0.5 1.0 N H:PRO54 4.7 0.1 1.0 CD H:PRO69 4.8 0.0 1.0 N H:TYR48 4.9 0.8 1.0 N H:PRO69 5.0 0.0 1.0

Zinc binding site 3 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn1001 b:0.9 occ:1.00 ND1 H:HIS226 2.0 0.9 1.0 NE2 H:HIS220 2.0 0.1 1.0 SG H:CYS201 2.1 0.7 1.0 SG H:CYS204 2.3 0.7 1.0 CE1 H:HIS226 2.3 0.9 1.0 CB H:CYS201 2.8 0.7 1.0 CE1 H:HIS220 3.0 0.1 1.0 CD2 H:HIS220 3.0 0.1 1.0 CG H:HIS226 3.2 0.9 1.0 CB H:CYS204 3.3 0.7 1.0 NE2 H:HIS226 3.5 0.9 1.0 CD2 H:HIS226 4.0 0.9 1.0 CB H:HIS226 4.0 0.9 1.0 ND1 H:HIS220 4.1 0.1 1.0 N H:CYS204 4.1 0.7 1.0 CG H:HIS220 4.1 0.1 1.0 CA H:CYS201 4.3 0.7 1.0 CA H:CYS204 4.3 0.7 1.0 C H:CYS201 4.7 0.7 1.0 O H:CYS201 4.8 0.7 1.0 CA H:HIS226 4.8 0.9 1.0 CE1 H:PHE221 4.8 97.3 1.0 CD1 H:PHE221 4.9 97.3 1.0

Zinc binding site 4 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ S:Zn1000 b:33.3 occ:1.00 SG S:CYS49 2.1 77.5 1.0 SG S:CYS46 2.3 0.1 1.0 SG S:CYS11 2.3 23.0 1.0 SG S:CYS86 2.3 50.5 1.0 CB S:CYS86 3.1 46.0 1.0 CB S:CYS11 3.2 20.8 1.0 CB S:CYS49 3.3 94.1 1.0 CB S:CYS46 3.8 0.7 1.0 N S:CYS46 4.0 0.3 1.0 N S:CYS49 4.3 68.8 1.0 CA S:CYS49 4.4 72.2 1.0 CA S:CYS46 4.4 0.9 1.0 CA S:CYS86 4.5 53.8 1.0 O S:CYS46 4.5 0.8 1.0 O S:CYS86 4.6 53.4 1.0 CA S:CYS11 4.7 39.2 1.0 CG S:LYS13 4.7 80.7 1.0 CB S:LYS13 4.8 64.0 1.0 C S:CYS86 4.8 50.9 1.0 C S:CYS46 4.8 0.1 1.0 CB S:VAL45 4.9 0.5 1.0

Zinc binding site 5 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ S:Zn1001 b:76.5 occ:1.00 SG S:CYS61 2.2 0.2 1.0 SG S:CYS58 2.2 0.5 1.0 SG S:CYS23 2.3 0.1 1.0 SG S:CYS26 2.3 0.6 1.0 CB S:CYS58 2.9 0.4 1.0 CB S:CYS26 3.0 0.1 1.0 CB S:CYS61 3.3 0.6 1.0 N S:CYS61 3.7 0.3 1.0 CB S:CYS23 3.8 0.2 1.0 N S:CYS23 3.9 0.5 1.0 N S:CYS26 4.1 0.4 1.0 CA S:CYS61 4.1 0.0 1.0 CA S:CYS26 4.2 1.0 1.0 CA S:CYS58 4.4 0.2 1.0 CA S:CYS23 4.4 1.0 1.0 CB S:ILE60 4.6 75.8 1.0 OD1 S:ASN64 4.7 0.6 1.0 O S:CYS23 4.8 0.5 1.0 CB S:ASN64 4.8 0.1 1.0 C S:ILE60 4.9 0.6 1.0 C S:CYS61 4.9 0.3 1.0 C S:CYS58 4.9 0.7 1.0 C S:CYS23 4.9 0.7 1.0

Zinc binding site 6 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ S:Zn1002 b:19.2 occ:1.00 SG S:CYS73 2.1 0.8 1.0 SG S:CYS33 2.1 59.8 1.0 SG S:CYS76 2.2 95.4 1.0 SG S:CYS30 2.3 0.0 1.0 CB S:CYS76 3.1 88.8 1.0 CB S:CYS30 3.1 0.4 1.0 CB S:CYS73 3.4 0.2 1.0 CB S:CYS33 3.5 65.7 1.0 N S:CYS73 3.8 0.1 1.0 N S:CYS76 3.9 36.9 1.0 N S:CYS33 4.0 0.4 1.0 CA S:CYS76 4.1 39.3 1.0 CA S:CYS73 4.2 0.9 1.0 CA S:CYS33 4.3 0.7 1.0 CA S:CYS30 4.5 0.7 1.0 CB S:ILE32 4.8 0.2 1.0 C S:CYS73 4.8 0.8 1.0 O S:CYS30 4.8 0.4 1.0 CB S:SER35 4.8 56.4 1.0 C S:CYS30 4.9 0.7 1.0 O S:CYS73 4.9 0.3 1.0 C S:TYR72 5.0 76.2 1.0

Zinc binding site 7 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ T:Zn1000 b:0.0 occ:1.00 NE2 T:HIS298 2.4 0.0 1.0 ND1 T:HIS304 2.4 0.0 1.0 SG T:CYS282 2.5 0.0 1.0 SG T:CYS285 2.7 0.0 1.0 CE1 T:HIS298 3.1 0.0 1.0 CG T:HIS304 3.2 0.0 1.0 CB T:CYS285 3.2 0.0 1.0 CE1 T:HIS304 3.3 0.0 1.0 CD2 T:HIS298 3.5 0.0 1.0 CB T:HIS304 3.5 0.0 1.0 CB T:CYS282 3.6 0.0 1.0 N T:CYS285 3.9 0.0 1.0 CA T:CYS285 4.2 0.0 1.0 CA T:HIS304 4.2 0.0 1.0 ND1 T:HIS298 4.3 0.0 1.0 NE2 T:HIS304 4.3 0.0 1.0 CD2 T:HIS304 4.3 0.0 1.0 CB T:PHE284 4.4 0.0 1.0 CG T:HIS298 4.5 0.0 1.0 CD2 T:LEU299 4.5 0.0 1.0 C T:PHE284 4.6 0.0 1.0 CZ T:PHE289 4.9 0.0 1.0 CA T:PHE284 4.9 0.0 1.0 CE2 T:PHE289 5.0 0.0 1.0

Zinc binding site 8 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ T:Zn1001 b:30.0 occ:1.00 CE1 T:HIS440 1.8 0.3 1.0 NE2 T:HIS446 2.1 0.1 1.0 ND1 T:HIS440 2.1 0.3 1.0 SG T:CYS423 2.3 0.7 1.0 CD2 T:HIS446 2.4 0.1 1.0 SG T:CYS426 2.4 0.3 1.0 CE1 T:HIS446 2.7 0.1 1.0 NE2 T:HIS440 2.9 0.3 1.0 CG T:HIS446 3.1 0.1 1.0 ND1 T:HIS446 3.2 0.1 1.0 CG T:HIS440 3.3 0.3 1.0 CB T:CYS426 3.5 0.3 1.0 CG2 T:ILE425 3.6 60.3 1.0 CB T:CYS423 3.6 0.7 1.0 CD2 T:HIS440 3.7 0.3 1.0 N T:CYS426 4.1 33.0 1.0 CB T:HIS446 4.2 0.1 1.0 CA T:CYS426 4.4 33.0 1.0 CB T:HIS440 4.5 0.3 1.0 OH T:TYR431 4.5 55.3 1.0 CE2 T:TYR431 4.7 55.3 1.0 CA T:HIS446 4.9 0.0 1.0 CE1 T:PHE437 4.9 65.2 1.0 C T:ILE425 4.9 91.0 1.0 CA T:CYS423 4.9 0.0 1.0 CB T:ILE425 4.9 60.3 1.0

Zinc binding site 9 out of 9 in the Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Prespliceosome Structure Provides Insight Into Spliceosome Assembly and Regulation (Map A2) within 5.0Å range: probe atom residue distance (Å) B Occ U:Zn1000 b:20.5 occ:1.00 SG U:CYS71 2.0 0.6 1.0 NE2 U:HIS84 2.0 0.2 1.0 ND1 U:HIS90 2.0 0.1 1.0 SG U:CYS68 2.1 94.5 1.0 CE1 U:HIS84 2.7 0.8 1.0 CB U:CYS71 2.9 0.4 1.0 CE1 U:HIS90 2.9 0.3 1.0 CG U:HIS90 3.0 0.7 1.0 CD2 U:HIS84 3.1 0.5 1.0 CB U:CYS68 3.1 93.1 1.0 CB U:HIS90 3.4 0.1 1.0 CA U:HIS90 3.8 99.5 1.0 N U:CYS71 3.9 73.9 1.0 ND1 U:HIS84 3.9 0.4 1.0 NE2 U:HIS90 4.0 0.9 1.0 CA U:CYS71 4.0 71.8 1.0 CD2 U:HIS90 4.0 0.8 1.0 CG U:HIS84 4.1 0.9 1.0 CA U:CYS68 4.6 66.3 1.0 OG1 U:THR73 4.7 0.9 1.0 O U:HIS90 4.7 0.4 1.0 C U:HIS90 4.7 0.7 1.0 ND2 U:ASN93 4.7 1.0 1.0 N U:HIS90 4.8 0.4 1.0 CB U:LEU70 5.0 87.1 1.0

C.Plaschka, P.C.Lin, C.Charenton, K.Nagai. Prespliceosome Structure Provides Insights Into Spliceosome Assembly and Regulation. Nature V. 559 419 2018.
ISSN: ESSN 1476-4687
PubMed: 29995849
DOI: 10.1038/S41586-018-0323-8