Zinc in PDB 6g77: RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp

All present enzymatic activity of RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp:
2.7.11.1;

The structure of RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp, PDB code: 6g77 was solved by F.Prischi, M.M.Ali, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.66 / 2.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	51.143, 113.916, 62.183, 90.00, 90.24, 90.00
R / Rfree (%)	18.5 / 23.3

The binding sites of Zinc atom in the RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp (pdb code 6g77). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp, PDB code: 6g77:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn403 b:31.7 occ:1.00 NE2 A:HIS250 2.0 31.6 1.0 O2G A:ANP401 2.1 34.9 1.0 O2B A:ANP401 2.1 42.6 1.0 SG A:CYS234 2.3 35.5 1.0 CE1 A:HIS250 2.9 24.4 1.0 PB A:ANP401 2.9 32.5 1.0 N3B A:ANP401 3.1 30.1 1.0 CD2 A:HIS250 3.1 30.6 1.0 PG A:ANP401 3.2 40.4 1.0 CB A:CYS234 3.3 33.8 1.0 O1B A:ANP401 3.5 38.0 1.0 CA A:CYS234 3.6 35.0 1.0 O1G A:ANP401 4.0 47.8 1.0 ND1 A:HIS250 4.1 23.5 1.0 CG A:HIS250 4.2 29.7 1.0 NH1 A:ARG247 4.3 34.8 1.0 O3G A:ANP401 4.3 46.6 1.0 O3A A:ANP401 4.4 44.9 1.0 C A:CYS234 4.4 31.3 1.0 O5' A:ANP401 4.4 52.1 1.0 N A:GLY235 4.4 27.8 1.0 O A:HOH509 4.5 30.0 1.0 N A:CYS234 4.7 37.1 1.0 CG A:ARG197 4.8 31.7 1.0 CD A:ARG197 4.8 35.4 1.0 NH1 A:ARG197 4.9 47.6 1.0

Zinc binding site 2 out of 2 in the RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn403 b:31.1 occ:1.00 SG B:CYS234 1.9 30.0 1.0 NE2 B:HIS250 2.2 32.4 1.0 CE1 B:HIS250 2.3 28.4 1.0 O2B B:ANP401 2.3 28.3 1.0 O3G B:ANP401 2.4 38.1 1.0 N3B B:ANP401 3.1 45.1 1.0 CB B:CYS234 3.1 23.2 1.0 PB B:ANP401 3.3 39.0 1.0 PG B:ANP401 3.3 34.5 1.0 CA B:CYS234 3.4 28.8 1.0 CD2 B:HIS250 3.6 33.3 1.0 ND1 B:HIS250 3.6 20.9 1.0 O B:HOH526 3.7 30.9 1.0 O B:HOH513 3.9 26.4 1.0 O B:HOH554 3.9 27.3 1.0 NH1 B:ARG247 4.1 25.8 1.0 O2G B:ANP401 4.1 32.5 1.0 CG B:HIS250 4.2 30.2 1.0 C B:CYS234 4.3 31.5 1.0 N B:GLY235 4.3 27.2 1.0 O3A B:ANP401 4.3 50.7 1.0 O1B B:ANP401 4.4 37.0 1.0 O1G B:ANP401 4.5 38.6 1.0 N B:CYS234 4.6 35.3 1.0

F.Prischi, M.M.Ali. RSK4 N-Terminal Kinase Domain in Complex with Amp-Pnp To Be Published.