Zinc in PDB 6fhi: Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker.

Enzymatic activity of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker.

All present enzymatic activity of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker.:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker., PDB code: 6fhi was solved by M.Lukarska, S.Cusack, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.80
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 268.740, 147.520, 88.540, 90.00, 96.63, 90.00
R / Rfree (%) 23 / 27

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker. (pdb code 6fhi). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker., PDB code: 6fhi:

Zinc binding site 1 out of 1 in 6fhi

Go back to Zinc Binding Sites List in 6fhi
Zinc binding site 1 out of 1 in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 19-Mer Serine 5 Phosphorylated Pol II Ctd Peptide with A Truncated Linker. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn801

b:72.0
occ:1.00
 OD1 A:ASP421 3.4 40.3 1.0
OD2 A:ASP421 3.4 39.9 1.0
ND1 B:HIS562 3.7 47.0 1.0
CG A:ASP421 3.8 40.2 1.0
CD B:ARG556 4.0 46.8 1.0
CD B:LYS553 4.1 50.2 1.0
NZ B:LYS553 4.3 54.0 1.0
CE1 B:HIS562 4.4 48.6 1.0
CB B:ARG556 4.5 46.9 1.0
CE2 B:TYR557 4.5 53.8 1.0
CE B:LYS553 4.7 51.5 1.0
NH1 B:ARG556 4.8 43.4 1.0
CG B:ARG556 4.9 46.4 1.0
CG B:HIS562 4.9 46.6 1.0
CD2 B:TYR557 4.9 53.1 1.0
CA B:LYS553 5.0 45.7 1.0

Reference:

M.Claron, M.Lukarska, U.Uhrig, P.Sehr, P.Drncova, J.D.Lewis, D.W.Will, S.Cusack. Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction Between Heterotrimeric Influenza Polymerase and Pol II C-Terminal Domain To Be Published.
Page generated: Wed Dec 16 11:48:15 2020

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