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Zinc in PDB 6fhh: Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated.

Enzymatic activity of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated.

All present enzymatic activity of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated.:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated., PDB code: 6fhh was solved by M.Lukarska, S.Cusack, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.70
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 267.770, 147.810, 88.410, 90.00, 97.08, 90.00
R / Rfree (%) 21.3 / 25.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated. (pdb code 6fhh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated., PDB code: 6fhh:

Zinc binding site 1 out of 1 in 6fhh

Go back to Zinc Binding Sites List in 6fhh
Zinc binding site 1 out of 1 in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter Bound to A 22-Mer Modified Pol II Ctd Peptide with Serine 5 Thiophosphorylated. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn801

b:82.3
occ:1.00
 O B:HOH943 3.1 54.7 1.0
OD2 A:ASP421 3.5 53.1 1.0
OD1 A:ASP421 3.5 54.1 1.0
ND1 B:HIS562 3.7 58.0 1.0
CG A:ASP421 3.9 50.4 1.0
NZ B:LYS553 4.1 69.3 1.0
CD B:LYS553 4.1 64.2 1.0
CE2 B:TYR557 4.3 63.6 1.0
CD B:ARG556 4.3 56.0 1.0
CE1 B:HIS562 4.3 58.6 1.0
CE B:LYS553 4.5 67.3 1.0
CB B:ARG556 4.6 54.0 1.0
CD2 B:TYR557 4.7 62.4 1.0
CG B:HIS562 4.8 58.3 1.0
NH1 B:ARG556 5.0 52.2 1.0

Reference:

M.Claron, M.Lukarska, U.Uhrig, P.Sehr, P.Drncova, J.D.Lewis, D.W.Will, S.Cusack. Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction Between Heterotrimeric Influenza Polymerase and Pol II C-Terminal Domain To Be Published.
Page generated: Mon Oct 28 21:04:30 2024

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