Zinc in PDB 6ck2: Insulin Analog Containing A YB26W Mutation

The structure of Insulin Analog Containing A YB26W Mutation, PDB code: 6ck2 was solved by N.K.Rege, V.C.Yee, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.03 / 2.25
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	79.755, 79.755, 37.610, 90.00, 90.00, 120.00
R / Rfree (%)	20.7 / 24.7

The structure of Insulin Analog Containing A YB26W Mutation also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Insulin Analog Containing A YB26W Mutation (pdb code 6ck2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Insulin Analog Containing A YB26W Mutation, PDB code: 6ck2:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Insulin Analog Containing A YB26W Mutation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Insulin Analog Containing A YB26W Mutation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn101 b:27.3 occ:0.33 NE2 B:HIS10 1.9 25.1 1.0 CE1 B:HIS10 2.9 25.5 1.0 CD2 B:HIS10 3.0 23.6 1.0 ND1 B:HIS10 4.0 26.0 1.0 CG B:HIS10 4.1 25.6 1.0

Zinc binding site 2 out of 2 in the Insulin Analog Containing A YB26W Mutation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Insulin Analog Containing A YB26W Mutation within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn101 b:17.5 occ:0.33 NE2 D:HIS10 2.0 14.5 1.0 CL D:CL102 2.3 13.2 0.3 CE1 D:HIS10 2.9 15.5 1.0 CD2 D:HIS10 3.0 14.2 1.0 ND1 D:HIS10 4.0 16.5 1.0 CG D:HIS10 4.1 16.8 1.0 CB D:LEU6 4.6 20.5 1.0 O D:LEU6 4.9 16.3 1.0

N.K.Rege, N.P.Wickramasinghe, A.N.Tustan, N.F.B.Phillips, V.C.Yee, F.Ismail-Beigi, M.A.Weiss. Structure-Based Stabilization of Insulin As A Therapeutic Protein Assembly Via Enhanced Aromatic-Aromatic Interactions. J. Biol. Chem. V. 293 10895 2018.
ISSN: ESSN 1083-351X
PubMed: 29880646
DOI: 10.1074/JBC.RA118.003650