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Zinc in PDB 6ck2: Insulin Analog Containing A YB26W Mutation

Protein crystallography data

The structure of Insulin Analog Containing A YB26W Mutation, PDB code: 6ck2 was solved by N.K.Rege, V.C.Yee, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.03 / 2.25
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 79.755, 79.755, 37.610, 90.00, 90.00, 120.00
R / Rfree (%) 20.7 / 24.7

Other elements in 6ck2:

The structure of Insulin Analog Containing A YB26W Mutation also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Insulin Analog Containing A YB26W Mutation (pdb code 6ck2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Insulin Analog Containing A YB26W Mutation, PDB code: 6ck2:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6ck2

Go back to Zinc Binding Sites List in 6ck2
Zinc binding site 1 out of 2 in the Insulin Analog Containing A YB26W Mutation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Insulin Analog Containing A YB26W Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn101

b:27.3
occ:0.33
NE2 B:HIS10 1.9 25.1 1.0
CE1 B:HIS10 2.9 25.5 1.0
CD2 B:HIS10 3.0 23.6 1.0
ND1 B:HIS10 4.0 26.0 1.0
CG B:HIS10 4.1 25.6 1.0

Zinc binding site 2 out of 2 in 6ck2

Go back to Zinc Binding Sites List in 6ck2
Zinc binding site 2 out of 2 in the Insulin Analog Containing A YB26W Mutation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Insulin Analog Containing A YB26W Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn101

b:17.5
occ:0.33
NE2 D:HIS10 2.0 14.5 1.0
CL D:CL102 2.3 13.2 0.3
CE1 D:HIS10 2.9 15.5 1.0
CD2 D:HIS10 3.0 14.2 1.0
ND1 D:HIS10 4.0 16.5 1.0
CG D:HIS10 4.1 16.8 1.0
CB D:LEU6 4.6 20.5 1.0
O D:LEU6 4.9 16.3 1.0

Reference:

N.K.Rege, N.P.Wickramasinghe, A.N.Tustan, N.F.B.Phillips, V.C.Yee, F.Ismail-Beigi, M.A.Weiss. Structure-Based Stabilization of Insulin As A Therapeutic Protein Assembly Via Enhanced Aromatic-Aromatic Interactions. J. Biol. Chem. V. 293 10895 2018.
ISSN: ESSN 1083-351X
PubMed: 29880646
DOI: 10.1074/JBC.RA118.003650
Page generated: Wed Dec 16 11:36:47 2020

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