Zinc in PDB 6cax: Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805

All present enzymatic activity of Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805:
3.5.1.108;

The structure of Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805, PDB code: 6cax was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.99 / 1.25
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	35.760, 47.470, 48.230, 111.26, 109.17, 98.00
R / Rfree (%)	16 / 17.1

The structure of Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805 (pdb code 6cax). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805, PDB code: 6cax:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn403 b:6.1 occ:1.00 OD1 A:ASP241 2.1 6.7 1.0 O24 A:EUY401 2.1 7.0 1.0 O26 A:EUY401 2.1 9.1 1.0 NE2 A:HIS237 2.1 5.0 1.0 NE2 A:HIS78 2.1 7.3 1.0 OD2 A:ASP241 2.6 8.0 1.0 CG A:ASP241 2.7 5.7 1.0 C23 A:EUY401 2.8 7.3 1.0 N25 A:EUY401 3.0 8.8 1.0 CE1 A:HIS237 3.1 5.4 1.0 CD2 A:HIS78 3.1 6.3 1.0 CD2 A:HIS237 3.1 5.1 1.0 CE1 A:HIS78 3.1 7.2 1.0 OG1 A:THR190 3.9 6.8 1.0 ND1 A:HIS237 4.2 5.2 1.0 CB A:ASP241 4.2 6.2 1.0 CG A:GLU77 4.2 7.6 1.0 CG A:HIS237 4.2 5.4 1.0 CB A:THR190 4.2 5.7 1.0 ND1 A:HIS78 4.2 8.4 1.0 CG A:HIS78 4.2 5.6 1.0 C02 A:EUY401 4.3 7.0 1.0 OE2 A:GLU77 4.3 8.5 1.0 O29 A:EUY401 4.7 14.4 1.0 CE1 A:HIS264 4.7 8.7 1.0 NE2 A:HIS264 4.8 10.0 1.0 C28 A:EUY401 4.8 14.2 1.0 CD A:GLU77 4.8 10.2 1.0 CA A:ASP241 4.8 5.7 1.0 CA A:THR190 4.8 5.2 1.0 O A:HIS237 4.9 5.3 1.0 S27 A:EUY401 4.9 11.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn404 b:17.1 occ:0.45 OD1 A:ASP277 2.0 17.2 1.0 O A:HOH542 2.0 18.0 0.4 OD2 A:ASP279 2.0 24.0 0.4 OD1 A:ASP279 2.5 23.1 0.4 CG A:ASP279 2.6 20.1 0.4 CG A:ASP277 2.8 12.7 1.0 OD2 A:ASP277 3.1 16.6 1.0 CB A:ASP279 3.5 16.1 0.6 OD2 A:ASP279 3.7 23.8 0.6 CB A:ASP279 4.0 15.0 0.4 CG A:ASP279 4.1 19.1 0.6 CB A:ASP277 4.2 8.6 1.0 N A:ASP279 4.5 10.3 1.0 CA A:ASP279 4.6 11.6 0.6 CA A:ASP277 4.6 7.8 1.0 CA A:ASP279 4.7 11.9 0.4 C A:ASP277 4.8 6.5 1.0 N A:ALA280 4.9 8.4 1.0 C A:ASP279 4.9 10.9 1.0

J.N.Phan, S.L.Delker, D.D.Lorimer, P.S.Horanyi, T.E.Edwards. Crystal Structure of Lpxc From Pseudomonas Aeruginosa in Complex with PT805 To Be Published.