Zinc in PDB 6bse: Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence

The structure of Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence, PDB code: 6bse was solved by M.A.Pufall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	16.75 / 2.35
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	39.447, 95.172, 104.719, 90.00, 90.00, 90.00
R / Rfree (%)	19.2 / 22.9

The binding sites of Zinc atom in the Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence (pdb code 6bse). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence, PDB code: 6bse:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:34.3 occ:1.00 SG A:CYS424 2.2 29.8 1.0 SG A:CYS438 2.3 35.6 1.0 SG A:CYS421 2.4 29.0 1.0 SG A:CYS441 2.4 35.8 1.0 HB3 A:CYS424 3.1 29.4 1.0 HB2 A:CYS441 3.1 34.6 1.0 H A:CYS438 3.2 44.8 1.0 CB A:CYS424 3.3 24.5 1.0 HB3 A:CYS421 3.3 44.9 1.0 H A:CYS424 3.3 37.4 1.0 CB A:CYS421 3.3 37.4 1.0 HB2 A:CYS421 3.4 44.9 1.0 HB3 A:CYS438 3.4 51.0 1.0 CB A:CYS441 3.4 28.8 1.0 CB A:CYS438 3.5 42.5 1.0 HB A:VAL423 3.7 29.5 1.0 H A:CYS441 3.7 35.3 1.0 HH11 A:ARG470 3.7 62.1 1.0 N A:CYS424 3.8 31.2 1.0 HG A:SER440 3.8 52.6 1.0 HB3 A:ASP426 3.8 48.9 1.0 HH21 A:ARG477 4.0 44.3 1.0 N A:CYS438 4.0 37.4 1.0 HB2 A:CYS424 4.0 29.4 1.0 HB3 A:CYS441 4.0 34.6 1.0 CA A:CYS424 4.0 32.1 1.0 HB2 A:ASP426 4.2 48.9 1.0 OG A:SER440 4.2 43.8 1.0 H A:ASP426 4.2 49.0 1.0 HB2 A:CYS438 4.3 51.0 1.0 N A:CYS441 4.3 29.4 1.0 NH1 A:ARG470 4.3 51.7 1.0 HH12 A:ARG470 4.3 62.1 1.0 CA A:CYS438 4.3 36.2 1.0 H A:VAL423 4.4 33.5 1.0 CA A:CYS441 4.4 28.7 1.0 CB A:ASP426 4.4 40.7 1.0 HB A:THR437 4.5 33.9 1.0 HG12 A:VAL423 4.5 39.5 1.0 CB A:VAL423 4.6 24.6 1.0 C A:CYS424 4.6 23.4 1.0 H A:SER425 4.6 28.8 1.0 HD2 A:ARG470 4.7 43.3 1.0 C A:VAL423 4.7 32.3 1.0 HA A:THR437 4.7 33.7 1.0 NH2 A:ARG477 4.7 36.9 1.0 CA A:CYS421 4.8 36.2 1.0 N A:SER425 4.8 24.0 1.0 HA A:CYS441 4.8 34.4 1.0 N A:ASP426 4.9 40.9 1.0 HA A:CYS424 4.9 38.5 1.0 HD3 A:ARG470 4.9 43.3 1.0 O A:CYS438 5.0 31.6 1.0 CG1 A:VAL423 5.0 32.9 1.0 HE A:ARG477 5.0 31.8 1.0 C A:CYS438 5.0 41.2 1.0

Zinc binding site 2 out of 4 in the Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:28.6 occ:1.00 SG A:CYS473 2.2 28.9 1.0 SG A:CYS457 2.2 39.5 1.0 SG A:CYS463 2.3 26.6 1.0 SG A:CYS476 2.5 30.8 1.0 HB2 A:CYS463 3.0 28.3 1.0 HB2 A:CYS476 3.0 33.0 1.0 HB2 A:CYS457 3.0 42.1 1.0 CB A:CYS457 3.2 35.1 1.0 H A:CYS463 3.2 29.5 1.0 CB A:CYS463 3.2 23.6 1.0 CB A:CYS473 3.3 24.9 1.0 CB A:CYS476 3.4 27.5 1.0 HB3 A:CYS473 3.4 29.9 1.0 HB2 A:CYS473 3.4 29.9 1.0 HA A:ASN461 3.5 34.9 1.0 HA A:CYS457 3.6 34.4 1.0 H A:CYS476 3.7 36.2 1.0 H A:ASN461 3.8 33.9 1.0 O A:HOH731 3.8 26.4 1.0 HB3 A:CYS463 3.9 28.3 1.0 N A:CYS463 4.0 24.6 1.0 CA A:CYS457 4.0 28.7 1.0 H A:GLY459 4.0 42.6 1.0 HB3 A:CYS457 4.0 42.1 1.0 HB3 A:CYS476 4.0 33.0 1.0 H A:ALA458 4.2 37.7 1.0 CA A:CYS463 4.2 24.0 1.0 H A:ASP462 4.2 38.9 1.0 CA A:ASN461 4.3 29.1 1.0 N A:CYS476 4.3 30.1 1.0 N A:ASN461 4.4 28.2 1.0 CA A:CYS476 4.4 32.0 1.0 HB3 A:ALA475 4.5 30.4 1.0 O A:HOH718 4.5 31.8 1.0 N A:ASP462 4.5 32.4 1.0 HH21 A:ARG479 4.6 44.7 1.0 HA3 A:GLY459 4.6 33.8 1.0 HA A:CYS476 4.6 38.5 1.0 C A:ASN461 4.7 41.1 1.0 N A:ALA458 4.7 31.4 1.0 CA A:CYS473 4.7 29.6 1.0 O A:HOH730 4.7 33.5 1.0 HA A:CYS463 4.7 28.8 1.0 C A:CYS457 4.8 29.5 1.0 N A:GLY459 4.8 35.5 1.0 HA A:CYS473 4.9 35.5 1.0

Zinc binding site 3 out of 4 in the Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:42.9 occ:1.00 SG B:CYS441 2.2 43.3 1.0 SG B:CYS424 2.3 44.9 1.0 SG B:CYS438 2.3 42.1 1.0 SG B:CYS421 2.3 46.3 1.0 HB2 B:CYS441 2.9 40.2 1.0 HB3 B:CYS424 3.1 37.4 1.0 H B:CYS438 3.1 47.4 1.0 HB3 B:CYS421 3.1 53.1 1.0 CB B:CYS441 3.2 33.5 1.0 H B:CYS424 3.2 59.7 1.0 CB B:CYS421 3.2 44.2 1.0 CB B:CYS424 3.3 31.2 1.0 HB2 B:CYS421 3.3 53.1 1.0 HH11 B:ARG470 3.5 45.3 1.0 HB3 B:CYS438 3.6 58.2 1.0 CB B:CYS438 3.6 48.5 1.0 H B:CYS441 3.7 40.8 1.0 HB B:VAL423 3.7 54.7 1.0 N B:CYS424 3.7 49.7 1.0 HB3 B:ASP426 3.8 65.1 1.0 HB3 B:CYS441 3.8 40.2 1.0 N B:CYS438 3.9 39.5 1.0 HG B:SER440 4.0 52.9 1.0 HH21 B:ARG477 4.0 52.5 1.0 CA B:CYS424 4.1 39.2 1.0 HB2 B:CYS424 4.1 37.4 1.0 NH1 B:ARG470 4.1 37.7 1.0 HH12 B:ARG470 4.2 45.3 1.0 N B:CYS441 4.3 34.0 1.0 HB2 B:ASP426 4.3 65.1 1.0 CA B:CYS438 4.3 40.0 1.0 CA B:CYS441 4.3 33.4 1.0 HB2 B:CYS438 4.3 58.2 1.0 HB B:THR437 4.4 58.0 1.0 H B:ASP426 4.4 59.5 1.0 H B:SER425 4.4 58.2 1.0 H B:VAL423 4.4 62.9 1.0 CB B:ASP426 4.5 54.3 1.0 HD2 B:ARG470 4.5 53.8 1.0 OG B:SER440 4.5 44.1 1.0 HG12 B:VAL423 4.6 40.1 1.0 CB B:VAL423 4.6 45.6 1.0 HA B:THR437 4.7 48.9 1.0 CA B:CYS421 4.7 60.6 1.0 C B:VAL423 4.7 44.5 1.0 HA B:CYS441 4.7 40.1 1.0 C B:CYS424 4.7 43.2 1.0 N B:SER425 4.8 48.5 1.0 NH2 B:ARG477 4.8 43.8 1.0 HD3 B:ARG470 4.9 53.8 1.0 HA B:CYS424 4.9 47.0 1.0 HE B:ARG477 4.9 48.8 1.0 C B:CYS438 5.0 39.0 1.0 N B:ASP426 5.0 49.6 1.0 CG1 B:VAL423 5.0 33.4 1.0 CA B:VAL423 5.0 42.5 1.0

Zinc binding site 4 out of 4 in the Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Glucocorticoid Receptor Bound to High Cooperativity Monomer Sequence within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn602 b:28.6 occ:1.00 SG B:CYS473 2.2 28.9 1.0 SG B:CYS463 2.3 29.0 1.0 SG B:CYS476 2.3 33.4 1.0 SG B:CYS457 2.3 29.2 1.0 HB2 B:CYS463 2.9 35.6 1.0 HB2 B:CYS457 3.0 31.8 1.0 HB2 B:CYS476 3.1 31.6 1.0 CB B:CYS463 3.2 29.7 1.0 CB B:CYS457 3.2 26.5 1.0 H B:CYS463 3.3 31.3 1.0 CB B:CYS473 3.4 34.2 1.0 CB B:CYS476 3.4 26.3 1.0 HB3 B:CYS473 3.4 41.0 1.0 HB2 B:CYS473 3.4 41.0 1.0 HA B:CYS457 3.6 32.6 1.0 O B:HOH709 3.7 27.8 1.0 HA B:ASN461 3.7 39.1 1.0 H B:CYS476 3.8 43.5 1.0 N B:CYS463 3.9 26.1 1.0 HB3 B:CYS463 3.9 35.6 1.0 CA B:CYS457 4.0 27.2 1.0 HB3 B:CYS476 4.0 31.6 1.0 H B:ASN461 4.0 30.5 1.0 HB3 B:CYS457 4.0 31.8 1.0 H B:GLY459 4.0 34.9 1.0 H B:ASP462 4.1 30.1 1.0 CA B:CYS463 4.2 23.1 1.0 HB3 B:ALA475 4.3 41.2 1.0 O B:HOH713 4.3 27.1 1.0 N B:CYS476 4.3 36.2 1.0 H B:ALA458 4.3 32.0 1.0 CA B:ASN461 4.4 32.6 1.0 HH21 B:ARG479 4.4 0.2 1.0 CA B:CYS476 4.5 28.3 1.0 N B:ASP462 4.5 25.0 1.0 N B:ASN461 4.5 25.4 1.0 H B:ARG460 4.5 33.4 1.0 HA B:CYS463 4.6 27.7 1.0 N B:ALA458 4.7 26.7 1.0 C B:ASN461 4.8 34.7 1.0 CA B:CYS473 4.8 30.0 1.0 C B:CYS457 4.8 45.6 1.0 HA B:CYS476 4.8 33.9 1.0 N B:GLY459 4.9 29.1 1.0 HA B:CYS473 4.9 36.0 1.0 C B:ASP462 5.0 33.0 1.0

M.A.Pufall, L.Zhang. General and Sequence-Specific Roles For Dna in Glucocorticoid Receptor Dna-Binding Stoichiometry To Be Published.