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Zinc in PDB 6av0: Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)BenzonitrileEnzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)Benzonitrile
All present enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)Benzonitrile:
1.14.13.39; Protein crystallography data
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)Benzonitrile, PDB code: 6av0
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6av0:
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)Benzonitrile also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)Benzonitrile
(pdb code 6av0). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)Benzonitrile, PDB code: 6av0: Zinc binding site 1 out of 1 in 6av0Go back to Zinc Binding Sites List in 6av0
Zinc binding site 1 out
of 1 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl) Ethyl)-5-(3-(Methylamino)Propyl)Benzonitrile
Mono view Stereo pair view
Reference:
H.T.Do,
H.Y.Wang,
H.Li,
G.Chreifi,
T.L.Poulos,
R.B.Silverman.
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with A Fluorobenzene Linker. J. Med. Chem. V. 60 9360 2017.
Page generated: Wed Dec 16 11:30:43 2020
ISSN: ISSN 1520-4804 PubMed: 29091437 DOI: 10.1021/ACS.JMEDCHEM.7B01356 |
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