Zinc in PDB 5ynb: Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin

The structure of Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin, PDB code: 5ynb was solved by S.M.Wei, L.Yang, Z.H.Ke, Y.Chen, D.Y.Guo, C.P.Fan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.21 / 1.98
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	66.325, 70.206, 119.198, 90.00, 90.00, 90.00
R / Rfree (%)	18.7 / 23.1

The binding sites of Zinc atom in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin (pdb code 5ynb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin, PDB code: 5ynb:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:37.8 occ:1.00 NE2 B:HIS83 2.1 60.0 1.0 SG B:CYS90 2.3 44.0 1.0 SG B:CYS77 2.3 36.2 1.0 SG B:CYS74 2.4 41.3 1.0 CD2 B:HIS83 2.8 51.7 1.0 CB B:CYS74 3.2 42.0 1.0 CB B:CYS90 3.2 47.3 1.0 CE1 B:HIS83 3.3 52.0 1.0 CB B:CYS77 3.4 35.2 1.0 N B:CYS77 3.4 38.8 1.0 CA B:CYS77 3.9 35.3 1.0 CG B:HIS83 4.0 48.9 1.0 ND1 B:HIS83 4.3 48.4 1.0 CB B:TYR76 4.4 37.9 1.0 C B:TYR76 4.4 39.2 1.0 CA B:CYS90 4.4 50.9 1.0 CA B:CYS74 4.6 38.1 1.0 CB B:LYS93 4.7 44.7 1.0 CA B:TYR76 4.8 36.8 1.0 N B:LYS93 4.9 44.6 1.0 N B:TYR76 4.9 36.6 1.0 O B:HOH323 5.0 58.3 1.0 C B:CYS74 5.0 35.6 1.0 CD2 B:TYR92 5.0 42.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mers-Cov NSP16/NSP10 Complex Bound to Sinefungin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:64.2 occ:1.00 SG B:CYS128 2.2 64.5 1.0 SG B:CYS117 2.3 85.4 1.0 SG B:CYS130 2.4 87.7 1.0 CB B:CYS120 2.6 88.5 1.0 SG B:CYS120 2.7 82.1 1.0 CB B:CYS117 3.2 77.4 1.0 CB B:CYS130 3.2 91.0 1.0 CB B:CYS128 3.5 60.1 1.0 CA B:CYS120 3.9 91.0 1.0 N B:CYS130 4.2 91.3 1.0 CA B:CYS128 4.2 59.5 1.0 CA B:CYS130 4.3 98.5 1.0 N B:CYS120 4.4 0.9 1.0 C B:CYS120 4.5 89.7 1.0 CG1 B:VAL119 4.5 0.3 1.0 O B:CYS120 4.5 91.6 1.0 C B:CYS128 4.6 68.3 1.0 N B:ASN129 4.6 70.5 1.0 CA B:CYS117 4.7 74.6 1.0 C B:VAL119 4.8 0.9 1.0

S.M.Wei, L.Yang, Z.H.Ke, Q.Y.Liu, Y.Chen, Z.Z.Yang, D.Y.Guo, C.P.Fan. Structural Insights Into the Molecular Mechanism of Mers Coronavirus Rna Ribose 2'-O-Methylation By NSP16/NSP10 Protein Complex To Be Published.