Zinc in PDB 5y19: Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy- 4-Methylpentanamide.

The structure of Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy- 4-Methylpentanamide., PDB code: 5y19 was solved by A.K.Marapaka, Y.Zhang, A.Addlagatta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.96 / 1.83
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	74.988, 109.258, 112.238, 90.00, 90.00, 90.00
R / Rfree (%)	16.6 / 20.7

The structure of Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy- 4-Methylpentanamide. also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy- 4-Methylpentanamide. (pdb code 5y19). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy- 4-Methylpentanamide., PDB code: 5y19:

Zinc binding site 1 out of 1 in the Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy- 4-Methylpentanamide.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy- 4-Methylpentanamide. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:22.6 occ:1.00 OE1 A:GLU519 1.9 19.5 1.0 O A:8KO1105 2.0 26.7 1.0 NE2 A:HIS500 2.1 20.5 1.0 NE2 A:HIS496 2.1 23.2 1.0 O2 A:8KO1105 2.2 39.1 1.0 CD A:GLU519 2.7 21.8 1.0 OE2 A:GLU519 2.9 20.7 1.0 C10 A:8KO1105 2.9 34.3 1.0 C A:8KO1105 2.9 30.9 1.0 CD2 A:HIS500 3.0 20.3 1.0 CD2 A:HIS496 3.0 24.8 1.0 CE1 A:HIS496 3.1 22.8 1.0 CE1 A:HIS500 3.1 18.8 1.0 CA A:8KO1105 3.6 26.9 1.0 N A:8KO1105 3.7 27.4 1.0 OE1 A:GLU497 3.9 23.9 1.0 N2 A:8KO1105 4.1 32.5 1.0 CG A:HIS500 4.1 17.1 1.0 ND1 A:HIS500 4.2 19.9 1.0 CG A:GLU519 4.2 20.3 1.0 ND1 A:HIS496 4.2 22.6 1.0 OH A:TYR580 4.2 22.2 1.0 CG A:HIS496 4.2 20.2 1.0 CE2 A:TYR580 4.3 22.4 1.0 OE1 A:GLU463 4.3 22.6 1.0 OE2 A:GLU497 4.6 25.5 1.0 CZ A:TYR580 4.7 22.6 1.0 CD A:GLU497 4.7 27.5 1.0 CB A:GLU519 4.7 20.6 1.0 CG2 A:THR522 4.7 20.2 1.0 CA A:GLU519 4.7 20.3 1.0 CD A:GLU463 4.8 22.4 1.0 OE2 A:GLU463 4.8 22.1 1.0 C11 A:8KO1105 4.9 30.2 1.0 CB A:THR522 5.0 18.6 1.0 NZ A:LYS518 5.0 23.5 1.0

A.K.Marapaka, A.Addlagatta. Crystal Structure of Plasmodium Falciparum Aminopeptidase N in Complex with (S)-2-((2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanamido)- N-Hydroxy-4-Methylpentanamide. To Be Published.