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Zinc in PDB 5xu8: Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine

Enzymatic activity of Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine

All present enzymatic activity of Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine:
3.4.19.12;

Protein crystallography data

The structure of Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine, PDB code: 5xu8 was solved by C.Y.Chou, S.J.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.81
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 102.953, 54.650, 72.687, 90.00, 107.54, 90.00
R / Rfree (%) 17.9 / 23.8

Other elements in 5xu8:

The structure of Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine also contains other interesting chemical elements:

Chlorine (Cl) 5 atoms
Sodium (Na) 5 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine (pdb code 5xu8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine, PDB code: 5xu8:

Zinc binding site 1 out of 1 in 5xu8

Go back to Zinc Binding Sites List in 5xu8
Zinc binding site 1 out of 1 in the Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human USP2 in Complex with Ubiquitin and 6- Thioguanine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn702

b:31.6
occ:1.00
SG A:CYS425 2.3 31.2 1.0
SG A:CYS428 2.3 31.5 1.0
SG A:CYS479 2.4 35.2 1.0
SG A:CYS476 2.4 31.5 1.0
CB A:CYS425 3.1 29.5 1.0
CB A:CYS428 3.3 31.2 1.0
CB A:CYS476 3.3 37.9 1.0
CB A:CYS479 3.3 39.9 1.0
N A:CYS428 3.7 34.5 1.0
N A:CYS479 3.7 39.7 1.0
CA A:CYS428 4.1 33.3 1.0
CA A:CYS479 4.1 39.0 1.0
CB A:ARG478 4.4 40.4 1.0
CA A:CYS425 4.6 29.4 1.0
CB A:ASP427 4.6 41.2 1.0
CG A:LYS483 4.6 32.8 1.0
CA A:CYS476 4.7 32.9 1.0
C A:ARG478 4.7 42.2 1.0
C A:ASP427 4.8 39.4 1.0
C A:CYS428 4.9 32.3 1.0

Reference:

S.J.Chuang, S.C.Cheng, H.C.Tang, C.Y.Sun, C.Y.Chou. 6-Thioguanine Is A Noncompetitive and Slow Binding Inhibitor of Human Deubiquitinating Protease USP2 Sci Rep V. 8 3102 2018.
ISSN: ESSN 2045-2322
PubMed: 29449607
DOI: 10.1038/S41598-018-21476-W
Page generated: Wed Dec 16 11:21:15 2020

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