Zinc in PDB 5we0: Structural Basis For Shelterin Bridge Assembly

The structure of Structural Basis For Shelterin Bridge Assembly, PDB code: 5we0 was solved by J.-K.Kim, J.Liu, X.Hu, C.Yu, K.Roskamp, B.Sankaran, L.Huang, E.-A.Komives, F.Qiao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.71 / 2.30
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	56.720, 82.010, 103.510, 89.99, 89.98, 73.96
R / Rfree (%)	19.9 / 22.8

The binding sites of Zinc atom in the Structural Basis For Shelterin Bridge Assembly (pdb code 5we0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structural Basis For Shelterin Bridge Assembly, PDB code: 5we0:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structural Basis For Shelterin Bridge Assembly


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis For Shelterin Bridge Assembly within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:49.1 occ:1.00 NE2 B:HIS488 2.1 42.0 1.0 NE2 A:HIS49 2.1 49.8 1.0 SG B:CYS482 2.4 47.8 1.0 SG B:CYS479 2.5 47.3 1.0 CD2 B:HIS488 2.9 42.7 1.0 CE1 A:HIS49 3.0 49.3 1.0 CD2 A:HIS49 3.1 42.0 1.0 CE1 B:HIS488 3.2 42.0 1.0 CB B:CYS479 3.2 51.6 1.0 CB B:CYS482 3.4 45.5 1.0 N B:CYS482 3.6 44.3 1.0 CA B:CYS482 3.9 50.7 1.0 ND1 A:HIS49 4.1 45.8 1.0 CG B:HIS488 4.1 40.7 1.0 CG A:HIS49 4.2 44.3 1.0 ND1 B:HIS488 4.2 41.6 1.0 CB A:CYS48 4.3 42.1 1.0 C B:MET481 4.5 47.1 1.0 CA B:CYS479 4.6 55.0 1.0 CB B:MET481 4.7 46.3 1.0 C B:CYS479 4.9 52.6 1.0 O B:CYS479 4.9 52.6 1.0

Zinc binding site 2 out of 4 in the Structural Basis For Shelterin Bridge Assembly


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis For Shelterin Bridge Assembly within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn601 b:73.5 occ:1.00 NE2 E:HIS488 2.0 59.6 1.0 NE2 D:HIS49 2.1 64.0 1.0 SG E:CYS482 2.5 73.1 1.0 SG E:CYS479 2.6 79.8 1.0 CE1 E:HIS488 2.6 59.0 1.0 CB E:CYS479 2.9 81.8 1.0 CE1 D:HIS49 2.9 64.7 1.0 CD2 E:HIS488 3.2 52.9 1.0 CD2 D:HIS49 3.2 58.2 1.0 CB E:CYS482 3.5 81.7 1.0 N E:CYS482 3.6 80.5 1.0 ND1 E:HIS488 3.8 56.8 1.0 CA E:CYS482 4.0 81.9 1.0 ND1 D:HIS49 4.1 61.4 1.0 CG E:HIS488 4.1 52.8 1.0 CG D:HIS49 4.2 57.0 1.0 CA E:CYS479 4.3 87.4 1.0 CB D:CYS48 4.4 55.3 1.0 C E:MET481 4.5 79.6 1.0 CB E:MET481 4.5 72.9 1.0 C E:CYS479 4.7 87.0 1.0 CA E:MET481 4.9 79.0 1.0 N E:MET481 5.0 87.8 1.0

Zinc binding site 3 out of 4 in the Structural Basis For Shelterin Bridge Assembly


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structural Basis For Shelterin Bridge Assembly within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn601 b:48.7 occ:1.00 NE2 G:HIS49 2.1 49.1 1.0 NE2 H:HIS488 2.1 43.4 1.0 SG H:CYS479 2.4 47.0 1.0 SG H:CYS482 2.4 51.2 1.0 CE1 G:HIS49 2.8 48.3 1.0 CD2 H:HIS488 3.0 44.0 1.0 CD2 G:HIS49 3.1 43.7 1.0 CE1 H:HIS488 3.2 42.6 1.0 CB H:CYS479 3.2 52.1 1.0 CB H:CYS482 3.4 47.7 1.0 N H:CYS482 3.6 47.5 1.0 CA H:CYS482 3.9 50.2 1.0 ND1 G:HIS49 4.0 48.9 1.0 CG G:HIS49 4.1 45.9 1.0 CG H:HIS488 4.2 42.0 1.0 ND1 H:HIS488 4.2 41.0 1.0 CB G:CYS48 4.3 40.5 1.0 C H:MET481 4.5 47.6 1.0 CA H:CYS479 4.6 56.0 1.0 CB H:MET481 4.7 48.4 1.0 C H:CYS479 4.9 55.4 1.0

Zinc binding site 4 out of 4 in the Structural Basis For Shelterin Bridge Assembly


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structural Basis For Shelterin Bridge Assembly within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn601 b:72.0 occ:1.00 NE2 K:HIS488 1.9 57.5 1.0 NE2 J:HIS49 2.2 62.8 1.0 SG K:CYS482 2.4 69.7 1.0 SG K:CYS479 2.5 75.2 1.0 CE1 K:HIS488 2.7 56.8 1.0 CE1 J:HIS49 2.9 62.5 1.0 CD2 K:HIS488 3.1 53.8 1.0 CB K:CYS479 3.2 77.4 1.0 CD2 J:HIS49 3.2 58.3 1.0 CB K:CYS482 3.4 79.0 1.0 N K:CYS482 3.6 75.5 1.0 ND1 K:HIS488 3.9 58.1 1.0 CA K:CYS482 3.9 78.5 1.0 ND1 J:HIS49 4.1 58.6 1.0 CG K:HIS488 4.1 54.2 1.0 CG J:HIS49 4.2 55.5 1.0 CB J:CYS48 4.4 50.6 1.0 C K:MET481 4.4 75.9 1.0 CB K:MET481 4.5 70.8 1.0 CA K:CYS479 4.7 83.6 1.0 CA K:MET481 4.9 75.4 1.0 N K:MET481 4.9 82.9 1.0 C K:CYS479 5.0 82.0 1.0

J.K.Kim, J.Liu, X.Hu, C.Yu, K.Roskamp, B.Sankaran, L.Huang, E.A.Komives, F.Qiao. Structural Basis For Shelterin Bridge Assembly. Mol. Cell V. 68 698 2017.
ISSN: ISSN 1097-4164
PubMed: 29149597
DOI: 10.1016/J.MOLCEL.2017.10.032