Zinc in PDB 5w90: Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand

All present enzymatic activity of Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand:
3.5.2.6;

The structure of Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand, PDB code: 5w90 was solved by I.Garcia-Saez, P.S.Mercuri, R.Kahn, I.G.Shabalin, J.E.Raczynska, M.Jaskolski, W.Minor, C.Papamicael, J.M.Frere, M.Galleni, O.Dideberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.08 / 1.78
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	82.120, 76.775, 44.841, 90.00, 110.21, 90.00
R / Rfree (%)	11.2 / 15.5

The binding sites of Zinc atom in the Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand (pdb code 5w90). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand, PDB code: 5w90:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:14.2 occ:1.00 O A:HOH687 2.0 9.0 0.5 NE2 A:HIS234 2.0 8.8 1.0 OD2 A:ASP94 2.1 12.3 1.0 NE2 A:HIS95 2.1 7.8 1.0 O2 A:UNL306 2.2 23.3 0.5 O A:HOH403 2.4 13.1 0.5 O A:HOH657 2.5 9.3 0.5 CE1 A:HIS234 2.9 10.7 1.0 CG A:ASP94 2.9 11.9 1.0 CE1 A:HIS95 3.0 8.9 1.0 CD2 A:HIS95 3.1 8.3 1.0 CD2 A:HIS234 3.1 8.8 1.0 OD1 A:ASP94 3.2 13.8 1.0 S A:UNL306 3.4 11.6 0.5 ZN A:ZN302 3.6 12.1 1.0 O A:HOH425 3.7 45.0 1.0 O4 A:UNL306 3.7 21.9 0.5 NE2 A:HIS90 3.9 8.4 1.0 CE1 A:HIS90 4.0 9.6 1.0 O A:HOH531 4.1 7.7 0.5 ND1 A:HIS234 4.1 9.2 1.0 ND1 A:HIS95 4.1 9.8 1.0 O A:HOH620 4.1 3.9 0.5 CG A:HIS95 4.2 9.4 1.0 CG A:HIS234 4.2 9.8 1.0 O1 A:UNL306 4.3 27.3 0.5 CB A:ASP94 4.3 11.7 1.0 O3 A:UNL306 4.4 22.3 0.5 OG A:SER233 4.9 9.7 1.0 CD2 A:LEU44 5.0 14.6 1.0

Zinc binding site 2 out of 2 in the Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Fez-1 Metallo-Beta-Lactamase From Legionella Gormanii Modelled with Unknown Ligand within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:12.1 occ:1.00 O A:HOH687 2.0 9.0 0.5 ND1 A:HIS92 2.1 8.3 1.0 NE2 A:HIS168 2.1 10.2 1.0 NE2 A:HIS90 2.1 8.4 1.0 O A:HOH531 2.3 7.7 0.5 O2 A:UNL306 2.7 23.3 0.5 O1 A:UNL306 2.8 27.3 0.5 CE1 A:HIS92 3.0 9.0 1.0 CD2 A:HIS168 3.0 9.4 1.0 CE1 A:HIS168 3.1 10.1 1.0 CD2 A:HIS90 3.1 8.9 1.0 CE1 A:HIS90 3.1 9.6 1.0 CG A:HIS92 3.1 9.4 1.0 O A:HOH403 3.2 13.1 0.5 S A:UNL306 3.4 11.6 0.5 CB A:HIS92 3.5 8.8 1.0 ZN A:ZN301 3.6 14.2 1.0 O A:HOH657 4.1 9.3 0.5 NE2 A:HIS92 4.1 10.0 1.0 OD1 A:ASP94 4.2 13.8 1.0 ND1 A:HIS90 4.2 7.9 1.0 ND1 A:HIS168 4.2 9.4 1.0 CG A:HIS168 4.2 8.8 1.0 CG A:HIS90 4.2 8.7 1.0 CD2 A:HIS92 4.2 9.3 1.0 CD2 A:HIS95 4.4 8.3 1.0 O4 A:UNL306 4.4 21.9 0.5 O3 A:UNL306 4.4 22.3 0.5 O A:HOH620 4.4 3.9 0.5 NE2 A:HIS95 4.4 7.8 1.0 ND2 A:ASN197 4.5 11.4 1.0 O A:HOH757 4.7 25.5 0.5 O A:HOH425 4.8 45.0 1.0 OD2 A:ASP94 4.8 12.3 1.0 CG A:ASP94 4.9 11.9 1.0 CA A:HIS92 5.0 9.9 1.0

I.Garcia-Saez, P.S.Mercuri, C.Papamicael, R.Kahn, J.M.Frere, M.Galleni, G.M.Rossolini, O.Dideberg. Three-Dimensional Structure of Fez-1, A Monomeric Subclass B3 Metallo-Beta-Lactamase From Fluoribacter Gormanii, in Native Form and in Complex with D-Captopril. J. Mol. Biol. V. 325 651 2003.
ISSN: ISSN 0022-2836
PubMed: 12507470