Zinc in PDB 5w21: Crystal Structure of A 1:1:1 FGF23-FGFR1C-Aklotho Ternary Complex

All present enzymatic activity of Crystal Structure of A 1:1:1 FGF23-FGFR1C-Aklotho Ternary Complex:
2.7.10.1; 3.2.1.31;

The structure of Crystal Structure of A 1:1:1 FGF23-FGFR1C-Aklotho Ternary Complex, PDB code: 5w21 was solved by M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.80 / 3.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	283.301, 72.593, 95.329, 90.00, 91.98, 90.00
R / Rfree (%)	23 / 27.8

The binding sites of Zinc atom in the Crystal Structure of A 1:1:1 FGF23-FGFR1C-Aklotho Ternary Complex (pdb code 5w21). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of A 1:1:1 FGF23-FGFR1C-Aklotho Ternary Complex, PDB code: 5w21:

Zinc binding site 1 out of 1 in the Crystal Structure of A 1:1:1 FGF23-FGFR1C-Aklotho Ternary Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A 1:1:1 FGF23-FGFR1C-Aklotho Ternary Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1008 b:0.2 occ:1.00 OD2 A:ASP745 2.0 0.0 1.0 OD2 A:ASP815 2.0 0.4 1.0 OD1 A:ASP426 2.0 0.5 1.0 SG A:CYS739 2.3 84.9 1.0 CG A:ASP426 2.8 0.4 1.0 CG A:ASP745 2.9 0.6 1.0 CG A:ASP815 2.9 0.7 1.0 OD2 A:ASP426 3.0 0.4 1.0 OD1 A:ASP745 3.2 0.8 1.0 CB A:CYS739 3.4 78.5 1.0 OD1 A:ASP815 3.5 0.6 1.0 N A:CYS739 3.8 74.5 1.0 CB A:ASP815 4.0 97.9 1.0 CB A:ALA428 4.1 89.1 1.0 CA A:CYS739 4.2 66.0 1.0 CB A:ASP426 4.2 0.3 1.0 CB A:ALA738 4.3 65.4 1.0 CB A:ASP745 4.3 0.9 1.0 CA A:ASP815 4.5 83.5 1.0 CB A:SER742 4.7 84.7 1.0 C A:ALA738 4.8 86.0 1.0 OG A:SER742 4.8 87.2 1.0 N A:SER816 4.8 72.3 1.0 N A:ALA428 4.8 96.3 1.0 CA A:ASP426 5.0 90.7 1.0 CA A:ALA428 5.0 80.7 1.0

G.Chen, Y.Liu, R.Goetz, L.Fu, S.Jayaraman, M.C.Hu, O.W.Moe, G.Liang, X.Li, M.Mohammadi. Alpha-Klotho Is A Non-Enzymatic Molecular Scaffold For FGF23 Hormone Signalling. Nature V. 553 461 2018.
ISSN: ESSN 1476-4687
PubMed: 29342138
DOI: 10.1038/NATURE25451