Atomistry » Zinc » PDB 5v3g-5vdw » 5vc9
Atomistry »
  Zinc »
    PDB 5v3g-5vdw »
      5vc9 »

Zinc in PDB 5vc9: Zinc Finger of Human CXXC4 in Complex with Cpg Dna

Protein crystallography data

The structure of Zinc Finger of Human CXXC4 in Complex with Cpg Dna, PDB code: 5vc9 was solved by K.Liu, C.Xu, W.Tempel, J.R.Walker, C.H.Arrowsmith, C.Bountra, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.20 / 2.10
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 29.983, 40.290, 57.760, 70.98, 86.43, 67.83
R / Rfree (%) 21.1 / 24.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Zinc Finger of Human CXXC4 in Complex with Cpg Dna (pdb code 5vc9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Zinc Finger of Human CXXC4 in Complex with Cpg Dna, PDB code: 5vc9:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 5vc9

Go back to Zinc Binding Sites List in 5vc9
Zinc binding site 1 out of 4 in the Zinc Finger of Human CXXC4 in Complex with Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Zinc Finger of Human CXXC4 in Complex with Cpg Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1001

b:42.4
occ:1.00
SG C:CYS142 2.3 39.7 1.0
SG C:CYS139 2.3 44.3 1.0
SG C:CYS145 2.3 39.5 1.0
SG C:CYS172 2.3 40.4 1.0
CB C:CYS172 3.2 34.6 1.0
CB C:CYS145 3.3 43.7 1.0
CB C:CYS142 3.3 45.8 1.0
CB C:CYS139 3.4 46.8 1.0
N C:CYS139 3.6 43.0 1.0
CA C:CYS172 3.6 36.1 1.0
N C:GLY140 3.7 45.3 1.0
N C:CYS142 3.8 47.7 1.0
CA C:CYS139 3.9 46.7 1.0
N C:GLU173 4.0 42.6 1.0
CA C:CYS142 4.1 46.6 1.0
C C:CYS139 4.2 47.9 1.0
C C:CYS172 4.2 39.7 1.0
N C:CYS145 4.4 40.8 1.0
CA C:CYS145 4.4 39.9 1.0
N C:VAL141 4.4 50.2 1.0
O C:HOH1101 4.7 36.8 1.0
CA C:GLY140 4.7 45.2 1.0
C C:ARG138 4.8 45.0 1.0
C C:CYS142 4.8 46.7 1.0
N C:GLU174 4.9 46.7 1.0
O C:CYS142 4.9 42.4 1.0
N C:CYS172 4.9 34.0 1.0
C C:VAL141 5.0 51.2 1.0
CB C:ARG138 5.0 44.7 1.0
CG C:GLU174 5.0 53.4 1.0
C C:GLY140 5.0 47.7 1.0

Zinc binding site 2 out of 4 in 5vc9

Go back to Zinc Binding Sites List in 5vc9
Zinc binding site 2 out of 4 in the Zinc Finger of Human CXXC4 in Complex with Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Zinc Finger of Human CXXC4 in Complex with Cpg Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1002

b:37.4
occ:1.00
SG C:CYS151 2.3 43.0 1.0
SG C:CYS157 2.3 34.5 1.0
SG C:CYS167 2.3 35.8 1.0
SG C:CYS154 2.3 35.5 1.0
CB C:CYS167 3.2 34.0 1.0
CB C:CYS157 3.4 35.9 1.0
CB C:CYS154 3.4 40.1 1.0
CB C:CYS151 3.5 42.5 1.0
N C:CYS151 3.5 36.7 1.0
CA C:CYS167 3.6 32.1 1.0
N C:GLY152 3.8 42.5 1.0
N C:CYS154 3.8 43.8 1.0
CA C:CYS151 3.9 42.1 1.0
N C:LYS168 4.0 34.2 1.0
CD2 C:PHE169 4.2 49.1 1.0
CA C:CYS154 4.2 42.2 1.0
C C:CYS167 4.2 33.1 1.0
N C:CYS157 4.3 34.6 1.0
C C:CYS151 4.3 44.6 1.0
CA C:CYS157 4.4 35.5 1.0
N C:VAL153 4.4 46.1 1.0
CE2 C:PHE169 4.6 52.7 1.0
C C:ASN150 4.6 39.1 1.0
CA C:GLY152 4.8 46.0 1.0
C C:CYS154 4.8 43.5 1.0
O C:CYS154 4.8 46.1 1.0
N C:CYS167 4.9 32.9 1.0
CA C:ASN150 4.9 37.8 1.0
N C:PHE169 5.0 35.5 1.0
C C:VAL153 5.0 47.6 1.0
C C:GLY152 5.0 46.6 1.0

Zinc binding site 3 out of 4 in 5vc9

Go back to Zinc Binding Sites List in 5vc9
Zinc binding site 3 out of 4 in the Zinc Finger of Human CXXC4 in Complex with Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Zinc Finger of Human CXXC4 in Complex with Cpg Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn1001

b:43.8
occ:1.00
SG F:CYS139 2.3 47.3 1.0
SG F:CYS172 2.3 40.4 1.0
SG F:CYS142 2.3 42.3 1.0
SG F:CYS145 2.3 37.6 1.0
CB F:CYS172 3.1 38.5 1.0
CB F:CYS139 3.2 49.3 1.0
CB F:CYS142 3.3 46.7 1.0
CB F:CYS145 3.4 40.2 1.0
N F:CYS139 3.5 43.3 1.0
CA F:CYS172 3.5 39.0 1.0
N F:GLY140 3.7 45.8 1.0
CA F:CYS139 3.8 47.7 1.0
N F:CYS142 3.8 48.9 1.0
N F:GLU173 3.9 44.5 1.0
C F:CYS139 4.1 48.3 1.0
C F:CYS172 4.1 43.6 1.0
CA F:CYS142 4.1 46.8 1.0
N F:CYS145 4.4 38.3 1.0
CA F:CYS145 4.4 36.8 1.0
N F:VAL141 4.5 51.5 1.0
C F:ARG138 4.7 44.8 1.0
CG F:GLU174 4.7 56.8 1.0
CA F:GLY140 4.7 47.9 1.0
N F:GLU174 4.8 55.4 1.0
N F:CYS172 4.8 39.3 1.0
CB F:ARG138 4.9 45.7 1.0
C F:CYS142 4.9 44.4 1.0
C F:VAL141 4.9 51.8 1.0
O F:HOH1105 4.9 36.0 1.0
C F:GLY140 5.0 49.6 1.0

Zinc binding site 4 out of 4 in 5vc9

Go back to Zinc Binding Sites List in 5vc9
Zinc binding site 4 out of 4 in the Zinc Finger of Human CXXC4 in Complex with Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Zinc Finger of Human CXXC4 in Complex with Cpg Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn1002

b:38.9
occ:1.00
SG F:CYS151 2.3 40.6 1.0
SG F:CYS157 2.3 36.6 1.0
SG F:CYS154 2.4 39.4 1.0
SG F:CYS167 2.4 34.6 1.0
CB F:CYS167 3.2 33.8 1.0
CB F:CYS154 3.4 39.4 1.0
CB F:CYS157 3.4 40.0 1.0
CB F:CYS151 3.4 39.6 1.0
CA F:CYS167 3.6 33.8 1.0
N F:CYS151 3.7 38.4 1.0
N F:GLY152 3.7 39.1 1.0
N F:CYS154 3.8 42.8 1.0
CA F:CYS151 3.9 38.2 1.0
N F:LYS168 4.0 38.9 1.0
CA F:CYS154 4.2 42.4 1.0
N F:CYS157 4.2 39.5 1.0
C F:CYS151 4.2 40.0 1.0
C F:CYS167 4.2 35.7 1.0
CA F:CYS157 4.4 41.2 1.0
N F:VAL153 4.5 42.8 1.0
C F:ASN150 4.7 37.0 1.0
CD2 F:PHE169 4.7 46.1 1.0
CA F:GLY152 4.7 42.7 1.0
C F:CYS154 4.8 44.0 1.0
O F:CYS154 4.9 40.2 1.0
N F:CYS167 4.9 33.0 1.0
N F:PHE169 5.0 38.4 1.0
C F:VAL153 5.0 45.4 1.0

Reference:

C.Xu, K.Liu, M.Lei, A.Yang, Y.Li, T.R.Hughes, J.Min. Dna Sequence Recognition of Human Cxxc Domains and Their Structural Determinants. Structure V. 26 85 2018.
ISSN: ISSN 1878-4186
PubMed: 29276034
DOI: 10.1016/J.STR.2017.11.022
Page generated: Mon Oct 28 12:47:46 2024

Last articles

As in 1D1T
As in 1D61
As in 1D1S
As in 1D1W
As in 1D1V
As in 1D0O
As in 1BIZ
As in 1C82
As in 1BHL
As in 1D0C
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy