Atomistry » Zinc » PDB 5uwm-5va4 » 5v48
Atomistry »
  Zinc »
    PDB 5uwm-5va4 »
      5v48 »

Zinc in PDB 5v48: Soluble Rabbit Neprilysin in Complex with Thiorphan

Enzymatic activity of Soluble Rabbit Neprilysin in Complex with Thiorphan

All present enzymatic activity of Soluble Rabbit Neprilysin in Complex with Thiorphan:
3.4.24.11;

Protein crystallography data

The structure of Soluble Rabbit Neprilysin in Complex with Thiorphan, PDB code: 5v48 was solved by S.L.Labiuk, P.Grochulski, J.Sygusch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.47 / 3.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.994, 108.446, 211.887, 90.00, 90.00, 90.00
R / Rfree (%) 19.5 / 24.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Soluble Rabbit Neprilysin in Complex with Thiorphan (pdb code 5v48). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Soluble Rabbit Neprilysin in Complex with Thiorphan, PDB code: 5v48:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5v48

Go back to Zinc Binding Sites List in 5v48
Zinc binding site 1 out of 2 in the Soluble Rabbit Neprilysin in Complex with Thiorphan


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Soluble Rabbit Neprilysin in Complex with Thiorphan within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn801

b:25.5
occ:1.00
OE1 A:GLU647 2.0 21.2 1.0
OE2 A:GLU647 2.0 28.2 1.0
NE2 A:HIS584 2.0 24.0 1.0
NE2 A:HIS588 2.0 24.2 1.0
SG1 A:TIO802 2.1 30.2 1.0
CD A:GLU647 2.3 26.0 1.0
CE1 A:HIS584 2.7 23.6 1.0
CE1 A:HIS588 2.8 24.0 1.0
CD2 A:HIS588 3.1 22.4 1.0
CD2 A:HIS584 3.2 21.4 1.0
CB1 A:TIO802 3.7 30.2 1.0
NE2 A:HIS712 3.8 25.5 1.0
CG A:GLU647 3.8 22.5 1.0
CA1 A:TIO802 3.9 30.2 1.0
ND1 A:HIS584 3.9 17.8 1.0
ND1 A:HIS588 4.0 24.6 1.0
CG A:HIS588 4.1 21.4 1.0
CG A:HIS584 4.2 21.9 1.0
CD2 A:HIS712 4.2 25.5 1.0
CB A:GLU647 4.5 21.5 1.0
CA A:GLU647 4.6 21.5 1.0
OE1 A:GLU585 4.7 21.5 1.0
CE1 A:HIS712 4.7 25.5 1.0
C A:TIO802 4.7 30.2 1.0
CB A:ALA650 4.8 22.7 1.0
O A:TIO802 5.0 30.2 1.0

Zinc binding site 2 out of 2 in 5v48

Go back to Zinc Binding Sites List in 5v48
Zinc binding site 2 out of 2 in the Soluble Rabbit Neprilysin in Complex with Thiorphan


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Soluble Rabbit Neprilysin in Complex with Thiorphan within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn801

b:49.2
occ:1.00
OE1 B:GLU647 2.0 39.7 1.0
OE2 B:GLU647 2.0 42.4 1.0
NE2 B:HIS588 2.0 41.6 1.0
NE2 B:HIS584 2.0 37.3 1.0
SG1 B:TIO802 2.1 43.6 1.0
CD B:GLU647 2.3 41.1 1.0
CE1 B:HIS588 3.0 34.8 1.0
CE1 B:HIS584 3.0 33.4 1.0
CD2 B:HIS584 3.0 33.0 1.0
CD2 B:HIS588 3.0 39.8 1.0
CB1 B:TIO802 3.4 43.6 1.0
CA1 B:TIO802 3.7 43.6 1.0
CG B:GLU647 3.8 39.0 1.0
NE2 B:HIS712 3.8 43.8 1.0
ND1 B:HIS588 4.1 34.6 1.0
ND1 B:HIS584 4.1 34.1 1.0
CG B:HIS588 4.2 36.1 1.0
CG B:HIS584 4.2 35.6 1.0
CD2 B:HIS712 4.2 39.6 1.0
OE2 B:GLU585 4.3 41.7 1.0
CB B:GLU647 4.6 36.2 1.0
O B:HOH994 4.6 27.7 1.0
C B:TIO802 4.7 43.6 1.0
CA B:GLU647 4.7 36.9 1.0
CB2 B:TIO802 4.7 43.6 1.0
CE1 B:HIS712 4.8 44.9 1.0
OE1 B:GLU585 4.8 38.4 1.0
CB B:ALA650 4.9 42.4 1.0
CD B:GLU585 4.9 38.7 1.0
CD1 B:TIO802 4.9 43.6 1.0
O B:TIO802 5.0 43.6 1.0

Reference:

S.L.Labiuk, J.Sygusch, P.Grochulski. Structures of Soluble Rabbit Neprilysin Complexed with Phosphoramidon or Thiorphan. Acta Crystallogr.,Sect.F V. 75 405 2019.
ISSN: ESSN 2053-230X
PubMed: 31204686
DOI: 10.1107/S2053230X19006046
Page generated: Wed Dec 16 11:07:44 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy