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Atomistry » Zinc » PDB 5tt5-5u0c » 5tza | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5tt5-5u0c » 5tza » |
Zinc in PDB 5tza: Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]PiperidineEnzymatic activity of Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine
All present enzymatic activity of Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine:
3.1.4.17; Protein crystallography data
The structure of Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine, PDB code: 5tza
was solved by
R.Xu,
K.Aertgeerts,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5tza:
The structure of Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine
(pdb code 5tza). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine, PDB code: 5tza: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 5tzaGo back to Zinc Binding Sites List in 5tza
Zinc binding site 1 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 5tzaGo back to Zinc Binding Sites List in 5tza
Zinc binding site 2 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 5tzaGo back to Zinc Binding Sites List in 5tza
Zinc binding site 3 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 5tzaGo back to Zinc Binding Sites List in 5tza
Zinc binding site 4 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with 3-{5-Methyl-[1,2, 4]Triazolo[1,5-A]Pyrimidin-7-Yl-1-[(Naphthalene-2-Yl) Carbonyl]Piperidine
Mono view Stereo pair view
Reference:
L.Gomez,
M.E.Massari,
T.Vickers,
G.Freestone,
W.Vernier,
K.Ly,
R.Xu,
M.Mccarrick,
T.Marrone,
M.Metz,
Y.G.Yan,
Z.W.Yoder,
R.Lemus,
N.J.Broadbent,
R.Barido,
N.Warren,
K.Schmelzer,
D.Neul,
D.Lee,
C.B.Andersen,
K.Sebring,
K.Aertgeerts,
X.Zhou,
A.Tabatabaei,
M.Peters,
J.G.Breitenbucher.
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2A) Inhibitors For the Treatment of Memory Disorders. J. Med. Chem. V. 60 2037 2017.
Page generated: Mon Oct 28 08:59:46 2024
ISSN: ISSN 1520-4804 PubMed: 28165743 DOI: 10.1021/ACS.JMEDCHEM.6B01793 |
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