Zinc in PDB 5txk: Crystal Structure of USP35 C450S in Complex with Ubiquitin

All present enzymatic activity of Crystal Structure of USP35 C450S in Complex with Ubiquitin:
3.4.19.12;

The structure of Crystal Structure of USP35 C450S in Complex with Ubiquitin, PDB code: 5txk was solved by G.Bader, A.Weiss-Puxbaum, A.Zoephel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.38 / 1.84
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	104.235, 104.235, 106.381, 90.00, 90.00, 90.00
R / Rfree (%)	16 / 18.3

The binding sites of Zinc atom in the Crystal Structure of USP35 C450S in Complex with Ubiquitin (pdb code 5txk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of USP35 C450S in Complex with Ubiquitin, PDB code: 5txk:

Zinc binding site 1 out of 1 in the Crystal Structure of USP35 C450S in Complex with Ubiquitin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of USP35 C450S in Complex with Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1006 b:19.3 occ:1.00 SG A:CYS583 2.3 18.6 1.0 SG A:CYS782 2.3 17.0 1.0 SG A:CYS580 2.3 17.3 1.0 SG A:CYS785 2.4 19.9 1.0 CB A:CYS580 3.2 13.4 1.0 CB A:CYS583 3.3 16.2 1.0 CB A:CYS782 3.3 13.6 1.0 CB A:CYS785 3.3 17.2 1.0 N A:CYS583 3.7 17.5 1.0 N A:CYS785 3.8 19.0 1.0 CA A:CYS583 4.1 16.5 1.0 CA A:CYS785 4.2 18.1 1.0 CB A:SER784 4.4 21.3 1.0 CG A:GLN789 4.5 16.5 1.0 CB A:CYS582 4.5 20.7 1.0 O A:HOH1321 4.5 48.4 1.0 CA A:CYS580 4.6 13.3 1.0 O A:HOH1341 4.6 15.8 1.0 C A:SER784 4.7 22.4 1.0 OG A:SER784 4.7 29.1 1.0 C A:CYS582 4.7 23.1 1.0 CA A:CYS782 4.7 13.1 1.0 C A:CYS583 4.9 19.3 1.0 CA A:SER784 5.0 18.0 1.0 CA A:CYS582 5.0 19.7 1.0

P.Leznicki, J.Natarajan, G.Bader, W.Spevak, A.Schlattl, S.A.Abdul Rehman, D.Pathak, S.Weidlich, A.Zoephel, M.C.Bordone, N.L.Barbosa-Morais, G.Boehmelt, Y.Kulathu. Expansion of Dub Functionality Generated By Alternative Isoforms - USP35, A Case Study. J. Cell. Sci. V. 131 2018.
ISSN: ESSN 1477-9137
PubMed: 29685892
DOI: 10.1242/JCS.212753