Zinc in PDB 5syt: Crystal Structure of ZMPSTE24

All present enzymatic activity of Crystal Structure of ZMPSTE24:
3.4.24.84;

The structure of Crystal Structure of ZMPSTE24, PDB code: 5syt was solved by K.Clark, J.L.Jenkins, N.Fedoriw, M.E.Dumont, Membrane Protein Structuralbiology Consortium (Mpsbc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.60 / 2.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	149.455, 84.560, 76.885, 90.00, 119.07, 90.00
R / Rfree (%)	21.8 / 24.9

The binding sites of Zinc atom in the Crystal Structure of ZMPSTE24 (pdb code 5syt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of ZMPSTE24, PDB code: 5syt:

Zinc binding site 1 out of 1 in the Crystal Structure of ZMPSTE24


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of ZMPSTE24 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn517 b:30.7 occ:1.00 OE2 A:GLU415 1.8 42.4 1.0 O A:HOH628 2.0 23.8 1.0 NE2 A:HIS339 2.0 28.5 1.0 NE2 A:HIS335 2.0 32.4 1.0 CD A:GLU415 2.7 40.3 1.0 OE1 A:GLU415 2.9 47.5 1.0 CE1 A:HIS339 2.9 30.8 1.0 CE1 A:HIS335 3.0 32.2 1.0 CD2 A:HIS335 3.1 30.6 1.0 HE1 A:HIS339 3.1 36.9 1.0 CD2 A:HIS339 3.1 29.3 1.0 HE1 A:HIS335 3.2 38.6 1.0 HD2 A:HIS335 3.3 36.7 1.0 HD2 A:HIS339 3.3 35.2 1.0 OE2 A:GLU336 3.7 45.6 1.0 HE1 A:HIS459 3.8 58.4 1.0 HA A:GLU415 3.9 39.7 1.0 HB3 A:ALA418 4.0 33.2 1.0 CG A:GLU415 4.0 40.8 1.0 ND1 A:HIS339 4.0 30.3 1.0 O A:HOH655 4.1 44.9 1.0 ND1 A:HIS335 4.1 31.0 1.0 CG A:HIS339 4.2 26.4 1.0 CG A:HIS335 4.2 29.9 1.0 HG2 A:GLU415 4.2 49.0 1.0 CD A:GLU336 4.4 46.3 1.0 HB1 A:ALA418 4.4 33.2 1.0 OE1 A:GLU336 4.5 45.7 1.0 CE1 A:HIS459 4.5 48.7 1.0 CB A:ALA418 4.6 27.7 1.0 HB2 A:ALA418 4.6 33.2 1.0 HG3 A:GLU415 4.6 49.0 1.0 HA A:GLU336 4.6 35.0 1.0 H41 A:C8E505 4.7 46.9 1.0 CA A:GLU415 4.8 33.1 1.0 HD1 A:HIS339 4.8 36.4 1.0 HD1 A:HIS459 4.8 63.5 1.0 HD1 A:HIS335 4.9 37.2 1.0 CB A:GLU415 4.9 36.0 1.0 HB3 A:GLU415 5.0 43.2 1.0 ND1 A:HIS459 5.0 53.0 1.0

K.M.Clark, J.L.Jenkins, N.Fedoriw, M.E.Dumont. Human Caax Protease ZMPSTE24 Expressed in Yeast: Structure and Inhibition By Hiv Protease Inhibitors. Protein Sci. V. 26 242 2017.
ISSN: ESSN 1469-896X
PubMed: 27774687
DOI: 10.1002/PRO.3074