Zinc in PDB 5svi: MORC3 Cw Domain in Complex with Unmodified Histone H3

The structure of MORC3 Cw Domain in Complex with Unmodified Histone H3, PDB code: 5svi was solved by Q.Tong, F.H.Andrews, T.G.Kutateladze, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.29 / 1.61
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	26.500, 31.060, 36.090, 107.81, 93.44, 90.21
R / Rfree (%)	18.3 / 22.1

The binding sites of Zinc atom in the MORC3 Cw Domain in Complex with Unmodified Histone H3 (pdb code 5svi). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the MORC3 Cw Domain in Complex with Unmodified Histone H3, PDB code: 5svi:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the MORC3 Cw Domain in Complex with Unmodified Histone H3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of MORC3 Cw Domain in Complex with Unmodified Histone H3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:17.9 occ:0.69 SG A:CYS413 2.3 18.3 1.0 SG A:CYS446 2.3 18.9 0.9 SG A:CYS416 2.4 18.8 0.9 SG A:CYS435 2.4 18.9 0.9 CB A:CYS413 3.0 18.7 1.0 CB A:CYS446 3.3 19.4 0.8 CB A:CYS435 3.3 19.9 0.9 CB A:CYS416 3.3 20.4 1.0 CA A:CYS446 3.5 17.7 1.0 N A:CYS416 3.8 18.7 1.0 N A:CYS435 3.9 17.5 0.9 CA A:CYS416 4.1 19.4 1.0 CA A:CYS435 4.2 19.6 1.0 N A:CYS446 4.3 20.3 1.0 CA A:CYS413 4.5 18.6 1.0 C A:CYS446 4.7 20.2 0.9 O A:CYS446 4.8 20.1 1.0 CB A:ALA415 4.8 22.9 0.9 C A:CYS416 4.9 19.9 1.0 C A:ALA415 4.9 21.3 0.8 NH2 A:ARG420 5.0 18.1 0.9

Zinc binding site 2 out of 2 in the MORC3 Cw Domain in Complex with Unmodified Histone H3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of MORC3 Cw Domain in Complex with Unmodified Histone H3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn100 b:19.1 occ:0.73 SG B:CYS29 2.3 19.2 1.0 SG B:CYS10 2.3 17.1 0.9 SG B:CYS40 2.3 18.6 0.9 SG B:CYS7 2.4 17.6 0.9 CB B:CYS7 3.1 19.5 1.0 CB B:CYS40 3.3 21.0 0.9 CB B:CYS10 3.3 20.2 0.9 CB B:CYS29 3.4 19.1 1.0 CA B:CYS40 3.5 17.9 1.0 N B:CYS10 3.9 18.6 1.0 N B:CYS29 3.9 17.7 0.9 CA B:CYS10 4.1 19.1 1.0 CA B:CYS29 4.2 17.6 0.8 N B:CYS40 4.3 21.0 1.0 CA B:CYS7 4.6 19.4 1.0 C B:CYS40 4.7 19.7 0.9 O B:CYS40 4.7 19.7 0.9 CB B:ALA9 4.8 22.5 1.0 C B:CYS10 4.8 19.6 0.8 C B:ALA9 5.0 21.6 0.9 NH2 B:ARG14 5.0 19.2 0.9

F.H.Andrews, Q.Tong, K.D.Sullivan, E.M.Cornett, Y.Zhang, M.Ali, J.Ahn, A.Pandey, A.H.Guo, B.D.Strahl, J.C.Costello, J.M.Espinosa, S.B.Rothbart, T.G.Kutateladze. Multivalent Chromatin Engagement and Inter-Domain Crosstalk Regulate MORC3 Atpase. Cell Rep V. 16 3195 2016.
ISSN: ESSN 2211-1247
PubMed: 27653685
DOI: 10.1016/J.CELREP.2016.08.050